Visual assessment of [11C]PIB PET in patients with cognitive impairment

• Published in: European journal of nuclear medicine and molecular imaging Vol. 37; no. 6; pp. 1141 - 1147
• Main Authors: Suotunen, Timo, Hirvonen, Jussi, Immonen-Räihä, Pirjo, Aalto, Sargo, Lisinen, Irina, Arponen, Eveliina, Teräs, Mika, Koski, Kari, Sulkava, Raimo, Seppänen, Marko, Rinne, Juha O.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2010; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Benzothiazoles - metabolism; Cardiology; Cognition & reasoning; Cognition Disorders - diagnostic imaging; Cognition Disorders - metabolism; Correlation analysis; Dementia - diagnostic imaging; Dementia - metabolism; Female; Humans; Imaging; Male; Medicine; Medicine & Public Health; Memory Disorders - diagnostic imaging; Memory Disorders - metabolism; Mental disorders; Middle Aged; Nuclear Medicine; Oncology; Original Article; Orthopedics; Patients; Positron-Emission Tomography - methods; Positron-Emission Tomography - standards; Radiology; Reference Standards; Visualization; Visual assessment; C-PIB; Alzheimer’s disease; PET; C-6-OH-BTA-1; Amyloid imaging
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-010-1382-8

Purpose The aim of this study was to evaluate the visual assessment of positron emission tomography images of N -[methyl-11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB) in a patient population with mild to moderate memory impairment or dementia. Methods We compared the visual ratings of two readers using kappa statistics and correlated the results of visual and quantitative region of interest (ROI) analyses. The one reader had good experience in evaluating PIB images and the other had little previous experience. The sensitivity and specificity of the visual assessment was determined using quantitative data from 18 healthy controls previously examined: [11C]PIB uptake was considered as abnormal if it was more than 2 SD above the mean of the healthy subjects. Results The evaluation of visual classification as “normal” or “abnormal” showed good interobserver agreement (κ = 0.90). There was a clear correlation between visual and quantitative analysis ( r  = 0.47–0.79, p  < 0.001). The most difficult visually assessed brain area was the putamen (κ = 0.11; correlation with quantitative analysis: reader A r  = 0.22; reader B r  = 0.60). Conclusion Our study shows that visual evaluation of [ 11 C]PIB images conforms with quantitative analyses also in a clinical patient population supporting the feasibility of visual evaluation in clinical settings.