Expression of Epidermal Growth Factor Receptor Changes in the Hypothalamus during the Onset of Female Puberty

• Published in: Molecular and cellular neuroscience Vol. 5; no. 3; pp. 246 - 262
• Main Authors: Ma, Ying Jun, Hill, Diane F., Junier, Marie-Pierre, Costa, Maria E., Felder, Stephen E., Ojeda, Sergio R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.1994
• Subjects: Animals; Astrocytes - metabolism; Base Sequence; Epidermal Growth Factor - physiology; Female; Gene Expression Regulation; Gonadotropin-Releasing Hormone - secretion; Hypothalamus - cytology; Hypothalamus - metabolism; Molecular Sequence Data; Neurons - metabolism; Phosphorylation; Polymerase Chain Reaction; Proestrus; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptor, Epidermal Growth Factor - biosynthesis; Receptor, Epidermal Growth Factor - genetics; Sexual Maturation; Transforming Growth Factor alpha - physiology

Recent findings have led to the concept that transforming growth factor alpha (TGFα) contributes to the neuroendocrine regulation of female puberty by stimulating the release of luteinizing hormone-releasing hormone (LHRH), the neurohormone controlling sexual development. It was postulated that this...