Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers

• Published in: Pain (Amsterdam) Vol. 153; no. 2; pp. 273 - 280
• Main Authors: Krumova, Elena K., Zeller, Martina, Westermann, Andrea, Maier, Christoph
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.02.2012; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Adult; Aged; Analgesics; Anesthetics, Local - administration & dosage; Biological and medical sciences; Double-Blind Method; Female; Fundamental and applied biological sciences. Psychology; Humans; Hyperalgesia - drug therapy; Hyperalgesia - physiopathology; Lidocaine - administration & dosage; Lidocaine patch (5%); Male; Mechanism-based treatment; Medical sciences; Middle Aged; Nerve Fibers, Myelinated - drug effects; Nerve Fibers, Myelinated - physiology; Nerve Fibers, Unmyelinated - drug effects; Nerve Fibers, Unmyelinated - physiology; Neural Conduction - drug effects; Neural Conduction - physiology; Neuropathic pain; Neuropharmacology; Pain - diagnosis; Pain - drug therapy; Pain - physiopathology; Pharmacology. Drug treatments; Placebos; Quantitative sensory testing; Small-fiber block; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Transdermal Patch; Treatment Outcome; Vertebrates: nervous system and sense organs; Young Adult; Mechanism-based treatment; Lidocaine patch (5%); Quantitative sensory testing; Small-fiber block; Neuropathic pain; Human; Pain sensitivity; Sensitivity disorder; Nervous system diseases; Hypoesthesia; Threshold detection; Hypoalgesia; Tactile sensitivity; Analgesic; Pain; Placebo; Detection threshold; Neurological disorder; Reliability; Lidocaine; Patch
• ISSN: 0304-3959; 1872-6623; 1872-6623
• DOI: 10.1016/j.pain.2011.08.020

Topical lidocaine (5%) induced a selective, but only partial blockade of Ad- and C-fibers of variable magnitude in healthy subjects, with significantly increased thermal detection and mechanical pain thresholds and decreased mechanical pain sensitivity. Topical lidocaine (5%) leads to sufficient pai...