The Effects of Aβ1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2

• Published in: International journal of molecular sciences Vol. 22; no. 15; p. 8226
• Main Authors: Hsu, John Tsu-An, Tien, Chih-Feng, Yu, Guann-Yi, Shen, Santai, Lee, Yi-Hsuan, Hsu, Pei-Chien, Wang, Yun, Chao, Po-Kuan, Tsay, Huey-Jen, Shie, Feng-Shiun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 30.07.2021; MDPI
• Subjects: ACE2; Alzheimer's disease; Angiotensin; Angiotensin-converting enzyme 2; Binding; Blood; Conversion; Coronaviruses; COVID-19; Dementia disorders; Inoculation; Interleukin 6; Intravenous administration; Middle East respiratory syndrome; Mutation; Older people; Peptidyl-dipeptidase A; Proteins; Respiratory diseases; SARS-CoV-2 spike protein; Severe acute respiratory syndrome coronavirus 2; Spike protein; Viral diseases; Viral infections; β-Amyloid

Increasing evidence suggests that elderly people with dementia are vulnerable to the development of severe coronavirus disease 2019 (COVID-19). In Alzheimer’s disease (AD), the major form of dementia, β-amyloid (Aβ) levels in the blood are increased; however, the impact of elevated Aβ levels on the...