Green Tea Seed Oil Suppressed Aβ1–42-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway

The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H2O2-induced PC12 cells and amyloid beta (Aβ)1–42-induced ICR mice. GTO sh...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 8; p. 1865
Main Authors Kim, Jong Min, Park, Seon Kyeong, Kang, Jin Yong, Park, Su Bin, Yoo, Seul Ki, Han, Hye Ju, Cho, Kyoung Hwan, Kim, Jong Cheol, Heo, Ho Jin
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 15.04.2019
MDPI
Subjects
AKT protein
amyloid β
Anti-inflammatory agents
Antioxidants
Aβ-related Akt pathway
Brain
Dietary fiber
Disease
Functional foods & nutraceuticals
Green tea
green tea seed oil
Inflammation
Ionic mobility
Liquid chromatography
Long term memory
Mass spectrometry
Mass spectroscopy
Memory
neuroprotective effect
Oilseeds
Oxidative stress
Peptides
Pheochromocytoma cells
Physiology
Polyphenols
Probiotics
Proteins
Quadrupoles
Seeds
Spatial discrimination learning
Spatial memory
Spices
Tea
Vitamins
Online AccessGet full text

Cover

Abstract The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H2O2-induced PC12 cells and amyloid beta (Aβ)1–42-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H2O2-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
AbstractList The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H2O2-induced PC12 cells and amyloid beta (Aβ)1-42-induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H2O2-induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
Nutraceuticals include dietary fiber, probiotics, prebiotics, polyunsaturated fatty acids, antioxidant vitamins, polyphenols, and spices, which are known to have antioxidant and anti-inflammatory properties [9]. [...]tea seeds are almost always discarded after harvest because they are not used to make oil, even though they contain a variety of physiologically active substances [15]. [...]the major aim of this study concerning the evaluation of availability of green tea oil, which is one of the byproducts of green tea, was to investigate the neuronal protective effect in PC12 cells and cognitive dysfunction-induced mice. 2. Identification of Main Compounds Using UPLC Q-TOF/MS2 The major physiological compounds of green tea seed oil (GTO) were qualitatively identified using ultra-performance liquid chromatography-ion mobility separation-quadrupole time of flight/tandem mass spectrometry (UPLC IMS Q-TOF/MS2) analysis (Figure 1 and Table 1). Morris Water Maze Test To measure spatial learning acquisition and long-term memory, a Morris water maze test was performed (Figure 5).
The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil. The ameliorating effect of green tea seed oil (GTO) was evaluated on H 2 O 2 -induced PC12 cells and amyloid beta (Aβ) 1–42 -induced ICR mice. GTO showed improvement of cell viability and reduced reactive oxygen species (ROS) production in H 2 O 2 -induced PC12 cells by conducting the 2′,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 2′,7′-dichlorofluorescein diacetate (DCF-DA) analysis. Also, administration of GTO (50 and 100 mg/kg body weight) presented protective effects on behavioral and memory dysfunction by conducting Y-maze, passive avoidance, and Morris water maze tests in Aβ-induced ICR mice. GTO protected the antioxidant system by reducing malondialdehyde (MDA) levels, and by increasing superoxide dismutase (SOD) and reducing glutathione (GSH) contents. It significantly regulated the cholinergic system of acetylcholine (ACh) contents, acetylcholinesterase (AChE) activities, and AChE expression. Also, mitochondrial function was improved through the reduced production of ROS and damage of mitochondrial membrane potential (MMP) by regulating the Aβ-related c-Jun N-terminal kinase (JNK)/protein kinase B (Akt) and Akt/apoptosis pathways. This study suggested that GTO may have an ameliorating effect on cognitive dysfunction and neurotoxicity through various physiological activities.
Author Heo
Han
Yoo
Cho
Kang
Kim
Park
AuthorAffiliation 1 Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea; myrock201@naver.com (J.M.K.); tjsrud2510@naver.com (S.K.P.); kangjy2132@naver.com (J.Y.K.); tbsk5670@naver.com (S.B.P.); ysyk9412@naver.com (S.K.Y.); gksgpwn2527@naver.com (H.J.H.)
2 Institute of Hadong Green Tea, Hadong 52304, Korea; ckh8568@hgreent.or.kr (K.H.C.); jckim@hgreent.or.kr (J.C.K.)
AuthorAffiliation_xml – name: 1 Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea; myrock201@naver.com (J.M.K.); tjsrud2510@naver.com (S.K.P.); kangjy2132@naver.com (J.Y.K.); tbsk5670@naver.com (S.B.P.); ysyk9412@naver.com (S.K.Y.); gksgpwn2527@naver.com (H.J.H.)
– name: 2 Institute of Hadong Green Tea, Hadong 52304, Korea; ckh8568@hgreent.or.kr (K.H.C.); jckim@hgreent.or.kr (J.C.K.)
Author_xml – sequence: 1
  givenname: Jong Min
  surname: Kim
  fullname: Kim, Jong Min
– sequence: 2
  givenname: Seon Kyeong
  surname: Park
  fullname: Park, Seon Kyeong
– sequence: 3
  givenname: Jin Yong
  surname: Kang
  fullname: Kang, Jin Yong
– sequence: 4
  givenname: Su Bin
  surname: Park
  fullname: Park, Su Bin
– sequence: 5
  givenname: Seul Ki
  surname: Yoo
  fullname: Yoo, Seul Ki
– sequence: 6
  givenname: Hye Ju
  surname: Han
  fullname: Han, Hye Ju
– sequence: 7
  givenname: Kyoung Hwan
  surname: Cho
  fullname: Cho, Kyoung Hwan
– sequence: 8
  givenname: Jong Cheol
  surname: Kim
  fullname: Kim, Jong Cheol
– sequence: 9
  givenname: Ho Jin
  surname: Heo
  fullname: Heo, Ho Jin
BookMark eNpdkktuFDEQhi0URB6w4wCW2LCgwY92294ghQHCSJGCSFhbbrt6xkOPPdjdg7LLHXITDsIhOAk9TIQSVvX661NVqY7RQUwREHpOyWvONXkTVuvCCFFUNeIROqI1YxUhjTy45x-i41JWhDDOhH6CDjnRmkohjtDmLANEfAUWXwJ4fBF6fDluNhlKmcLTXz_p75vbmlXz6Ec3Zd7B0m5DyrbHNno8S4sYhrAF_B664MKAt8HiYQm71uoL9HbYYb4N-LMdlj_s9VP0uLN9gWd39gR9_fjhavapOr84m89OzyvHJRGVJbzlTcu4pm3twLWi7axjotOeSN0o5qjzHWWk44422nkrlaRO0lpqz5zjJ2i-5_pkV2aTw9rma5NsMH8TKS-MzUNwPRgpaK2Y8i2Fuu4kU4xprx0lnBOpKJ9Yb_eszdiuwTuIw7T_A-jDSgxLs0hb00xk2ewAL-8AOX0foQxmHYqDvrcR0lgMY5Rowaimk_TFf9JVGnOcTmUY51xooVQ9qV7tVS6nUjJ0_4ahxOzewtx_C_4Hl5mrkA
CitedBy_id crossref_primary_10_3390_cimb43010033
crossref_primary_10_3389_fphys_2023_1216948
crossref_primary_10_1080_10799893_2020_1767136
crossref_primary_10_2147_JIR_S455155
crossref_primary_10_3390_molecules27165316
crossref_primary_10_3390_nu11051120
crossref_primary_10_3390_nu15112502
crossref_primary_10_1080_23311932_2023_2272464
crossref_primary_10_3390_ijms241612898
crossref_primary_10_3390_antiox9100976
crossref_primary_10_3390_foods12203821
crossref_primary_10_1134_S1021443722010071
crossref_primary_10_1007_s12017_020_08615_1
crossref_primary_10_1155_2022_7157444
crossref_primary_10_3390_antiox12040968
crossref_primary_10_4014_jmb_2207_07015
crossref_primary_10_1016_j_tifs_2023_104192
crossref_primary_10_1016_j_jff_2021_104398
Cites_doi 10.3109/13506120109007362
10.1042/bss0670151
10.1038/nrendo.2016.54
10.1016/j.neuint.2014.08.008
10.1126/science.7901908
10.1038/srep11708
10.1016/S0899-9007(02)00852-3
10.1016/j.foodres.2011.04.003
10.1080/09168451.2014.997184
10.1523/JNEUROSCI.18-23-09629.1998
10.1016/0006-8993(92)91352-F
10.1515/BC.2002.053
10.1016/j.aca.2007.07.027
10.3746/jkfn.2018.47.8.857
10.1080/09168451.2018.1433993
10.1016/j.foodchem.2010.06.076
10.1016/0006-2952(61)90145-9
10.1038/nrd3505
10.1021/acs.jafc.6b00559
10.1172/JCI57256
10.1016/j.foodchem.2016.09.016
10.1016/S0891-5849(00)00510-4
10.1037/0021-843X.95.3.252
10.1021/tx5000415
10.1016/0166-2236(89)90165-3
10.1111/j.1750-3639.2004.tb00088.x
10.3892/or.5.2.527
10.1139/o00-018
10.1111/j.1471-4159.2005.03530.x
10.1016/j.foodres.2017.09.089
10.1002/ptr.4978
10.1016/S0002-9440(10)63774-1
10.1016/j.molbrainres.2005.07.009
10.1016/j.fct.2009.11.043
10.1586/14737175.8.11.1703
10.1016/j.foodres.2017.11.059
10.1016/j.ejphar.2010.09.001
10.1155/2014/408503
10.1016/j.ejphar.2015.07.001
10.1016/j.ejps.2016.09.003
10.1172/JCI64595
10.1007/s13197-011-0269-4
10.1212/01.wnl.0000192103.24796.42
10.1016/j.neuroscience.2012.09.026
10.2174/1568007054038229
10.1002/ana.410360510
10.1016/S1044-0305(01)00226-4
10.3233/JAD-2011-101629
10.1016/0003-2697(76)90527-3
10.1016/0165-0270(84)90007-4
10.1016/j.jpba.2012.11.024
10.1002/cbdv.201800036
10.1023/B:JOBB.0000041775.10388.23
10.2217/bmm.09.89
10.1016/j.nlm.2014.07.005
10.1021/jf035079g
10.1037/0735-7044.121.2.324
10.5012/bkcs.2013.34.7.2199
ContentType Journal Article
Copyright 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2019 by the authors. 2019
Copyright_xml – notice: 2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2019 by the authors. 2019
DBID AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.3390/ijms20081865
DatabaseName CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni Edition)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
Research Library
Research Library (Corporate)
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest Research Library
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1422-0067
ExternalDocumentID oai_doaj_org_article_7514828db1e44f728229d9c103307813
10_3390_ijms20081865
GroupedDBID ---
29J
2WC
3V.
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABJCF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ADBBV
AEAQA
AENEX
AFKRA
AFPKN
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESTFP
ESX
F5P
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
GX1
HCIFZ
HH5
HMCUK
HYE
IAO
ITC
KB.
KQ8
LK8
M1P
M2O
M48
M7P
MODMG
M~E
O5R
O5S
OK1
P2P
PDBOC
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNS
RPM
TR2
TUS
UKHRP
~8M
7XB
8FK
K9.
MBDVC
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c3705-a03b36b2391b4cecb5bfac25f9d079682c1cdf120f3c169cda7871c71479d2cc3
IEDL.DBID RPM
ISSN 1422-0067
1661-6596
IngestDate Fri Oct 04 13:12:30 EDT 2024
Tue Sep 17 20:56:50 EDT 2024
Thu Jul 25 10:59:47 EDT 2024
Thu Oct 10 22:12:44 EDT 2024
Thu Sep 26 15:52:16 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3705-a03b36b2391b4cecb5bfac25f9d079682c1cdf120f3c169cda7871c71479d2cc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514763/
PMID 30991755
PQID 2333595884
PQPubID 2032341
ParticipantIDs doaj_primary_oai_doaj_org_article_7514828db1e44f728229d9c103307813
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6514763
proquest_miscellaneous_2210952191
proquest_journals_2333595884
crossref_primary_10_3390_ijms20081865
PublicationCentury 2000
PublicationDate 20190415
PublicationDateYYYYMMDD 2019-04-15
PublicationDate_xml – month: 4
  year: 2019
  text: 20190415
  day: 15
PublicationDecade 2010
PublicationPlace Basel
PublicationPlace_xml – name: Basel
PublicationTitle International journal of molecular sciences
PublicationYear 2019
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref13
ref57
ref12
ref56
ref15
ref14
ref58
ref52
ref11
ref55
ref10
ref54
ref17
ref16
ref19
ref18
Laursen (ref53) 1986; 16
ref51
ref50
ref46
ref45
ref48
ref47
ref42
ref41
ref44
ref43
ref49
ref8
ref7
ref9
ref4
ref3
ref6
ref5
ref40
ref35
ref34
ref36
ref31
ref30
Glenner (ref1) 1983; 107
ref33
ref32
ref2
ref39
ref38
ref24
Vincent (ref59) 1958; 16
ref23
ref26
ref25
ref20
ref22
ref21
ref28
ref27
ref29
Park (ref37) 2016; 64
ref60
ref61
References_xml – ident: ref52
  doi: 10.3109/13506120109007362
– ident: ref42
  doi: 10.1042/bss0670151
– ident: ref8
  doi: 10.1038/nrendo.2016.54
– ident: ref10
  doi: 10.1016/j.neuint.2014.08.008
– ident: ref24
  doi: 10.1126/science.7901908
– ident: ref49
  doi: 10.1038/srep11708
– ident: ref44
  doi: 10.1016/S0899-9007(02)00852-3
– ident: ref20
  doi: 10.1016/j.foodres.2011.04.003
– ident: ref31
  doi: 10.1080/09168451.2014.997184
– ident: ref40
  doi: 10.1523/JNEUROSCI.18-23-09629.1998
– ident: ref28
  doi: 10.1016/0006-8993(92)91352-F
– ident: ref22
  doi: 10.1515/BC.2002.053
– ident: ref19
  doi: 10.1016/j.aca.2007.07.027
– ident: ref11
  doi: 10.3746/jkfn.2018.47.8.857
– ident: ref29
  doi: 10.1080/09168451.2018.1433993
– ident: ref18
  doi: 10.1016/j.foodchem.2010.06.076
– ident: ref60
  doi: 10.1016/0006-2952(61)90145-9
– ident: ref4
  doi: 10.1038/nrd3505
– volume: 64
  start-page: 3353
  year: 2016
  ident: ref37
  article-title: Antiamnesic effect of broccoli (Brassica oleracea var. italica) leaves on amyloid beta (Aβ)1–42-induced learning and memory impairment
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.6b00559
  contributor:
    fullname: Park
– ident: ref47
  doi: 10.1172/JCI57256
– volume: 16
  start-page: 179
  year: 1958
  ident: ref59
  article-title: Colorimetric determination of acetylcholine by the Hestrin hydroxylamine reaction and its application in pharmacy
  publication-title: Ann. Pharm. Fr.
  contributor:
    fullname: Vincent
– ident: ref30
  doi: 10.1016/j.foodchem.2016.09.016
– ident: ref6
  doi: 10.1016/S0891-5849(00)00510-4
– volume: 107
  start-page: 281
  year: 1983
  ident: ref1
  article-title: Alzheimer’s disease. The commonest form of amyloidosis
  publication-title: Arch. Pathol. Lab. Med.
  contributor:
    fullname: Glenner
– ident: ref55
  doi: 10.1037/0021-843X.95.3.252
– ident: ref33
  doi: 10.1021/tx5000415
– ident: ref38
  doi: 10.1016/0166-2236(89)90165-3
– ident: ref5
  doi: 10.1111/j.1750-3639.2004.tb00088.x
– ident: ref12
  doi: 10.3892/or.5.2.527
– ident: ref58
  doi: 10.1139/o00-018
– ident: ref39
  doi: 10.1111/j.1471-4159.2005.03530.x
– ident: ref46
  doi: 10.1016/j.foodres.2017.09.089
– ident: ref21
  doi: 10.1002/ptr.4978
– ident: ref35
  doi: 10.1016/S0002-9440(10)63774-1
– ident: ref26
  doi: 10.1016/j.molbrainres.2005.07.009
– ident: ref43
  doi: 10.1016/j.fct.2009.11.043
– ident: ref34
  doi: 10.1586/14737175.8.11.1703
– ident: ref15
  doi: 10.1016/j.foodres.2017.11.059
– ident: ref3
  doi: 10.1016/j.ejphar.2010.09.001
– volume: 16
  start-page: 355
  year: 1986
  ident: ref53
  article-title: Intracerebroventricular injections in mice: Some methodological refinements
  publication-title: J. Pharmacol. Toxicol. Methods
  contributor:
    fullname: Laursen
– ident: ref50
  doi: 10.1155/2014/408503
– ident: ref32
  doi: 10.1016/j.ejphar.2015.07.001
– ident: ref7
  doi: 10.1016/j.ejps.2016.09.003
– ident: ref48
  doi: 10.1172/JCI64595
– ident: ref9
  doi: 10.1007/s13197-011-0269-4
– ident: ref41
  doi: 10.1212/01.wnl.0000192103.24796.42
– ident: ref51
  doi: 10.1016/j.neuroscience.2012.09.026
– ident: ref2
  doi: 10.2174/1568007054038229
– ident: ref23
  doi: 10.1002/ana.410360510
– ident: ref17
  doi: 10.1016/S1044-0305(01)00226-4
– ident: ref45
  doi: 10.3233/JAD-2011-101629
– ident: ref57
  doi: 10.1016/0003-2697(76)90527-3
– ident: ref56
  doi: 10.1016/0165-0270(84)90007-4
– ident: ref16
  doi: 10.1016/j.jpba.2012.11.024
– ident: ref36
  doi: 10.1002/cbdv.201800036
– ident: ref61
  doi: 10.1023/B:JOBB.0000041775.10388.23
– ident: ref25
  doi: 10.2217/bmm.09.89
– ident: ref13
  doi: 10.1016/j.nlm.2014.07.005
– ident: ref27
  doi: 10.1021/jf035079g
– ident: ref54
  doi: 10.1037/0735-7044.121.2.324
– ident: ref14
  doi: 10.5012/bkcs.2013.34.7.2199
SSID ssj0023259
Score 2.3937938
Snippet The aim of this study was to investigate the availability of seeds, one of the byproducts of green tea, and evaluate the physiological activity of seed oil....
Nutraceuticals include dietary fiber, probiotics, prebiotics, polyunsaturated fatty acids, antioxidant vitamins, polyphenols, and spices, which are known to...
SourceID doaj
pubmedcentral
proquest
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
StartPage 1865
SubjectTerms AKT protein
amyloid β
Anti-inflammatory agents
Antioxidants
Aβ-related Akt pathway
Brain
Dietary fiber
Disease
Functional foods & nutraceuticals
Green tea
green tea seed oil
Inflammation
Ionic mobility
Liquid chromatography
Long term memory
Mass spectrometry
Mass spectroscopy
Memory
neuroprotective effect
Oilseeds
Oxidative stress
Peptides
Pheochromocytoma cells
Physiology
Polyphenols
Probiotics
Proteins
Quadrupoles
Seeds
Spatial discrimination learning
Spatial memory
Spices
Tea
Vitamins
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NitswEBYlsNBL2f5Rb9OiQnsUsf4s67ibbQiF_kATyM3ozzTdrROabMve-g59kz7IPkSfZEeyE-LTXvYqyUae8Wi-YUbfIPS2oEVe2hAIC8wR4XQgpRScgCsSzACiNSld8PFTMZ2LDwu5OGj1FWvCWnrgVnAjJSNTZektDULUKlY9aq8dzSEQVyVteT6p3AVTXajFAdW3Ze4cgvrR8vuPDWvZ22TPASWe_h647JdGHviayTF61IFEfNpu7jF6EJon6KhtG3n9FK1TsQyeBYO_gvPBn5eXOHbnTDzgHp_e_KP___wVjMS-HA5GzvZ38bFpPB7vSobweYgEElv8a2kwIMH4KEnlcfE1F1v8BfDhb3P9DM0n72fjKek6JxDHVS6JybnlhWVcUytccFba2jgma-1zpYuSOep8TVlec0cL7bwBu6VOUaG0Z87x52jQrJrwAmEwastLz4wWuQg-GF0DSIBzMqjAmLIZercTZ7VuCTIqCCyi2KtDsWfoLMp6vybSWqcBUHbVKbu6S9kZGu40VXW2tqkY5_F2cVmKDL3ZT4OVxNSHacLqCtZAZKsBqWiaIdXTcG9D_Zlm-S3xbRewKziGT-7jC16ihwC5Uj6KyiEabH9ehVcAa7b2dfqDbwH2dfWd
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwELagCIkLKn8iUJCR4Gg1_okdn1BbWCokfiRaqbfIf6ELbXbpbql64x14Ex6Eh-BJmHGyS3PhGjuJNfbMfPaMvyHkuea6rH1KTCQRmAo2sbpSkoErUsIBonU5XPDuvd4_VG-PqqPhwG0xpFWubGI21HEW8Ix8W0iJd0jrWr2cf2NYNQqjq0MJjevkBkcmPLwpPnmz3nBJkYulcfBBTFdW94nvErb529MvpwvR87lVI5eUmftHcHOcLHnF-0w2ye0BNtKdfp7vkGupu0tu9oUkL--ReU6foQfJ0U_gjuiH6QnFep2ZGTzSnd-_-J8fP5VgWKkjwJPd9e186rpI91ZJRPRVQkqJJf0-dRSwIb7KcsIcfubrkn4ExHjhLu-Tw8nrg719NtRSYEGasmKulF5qL6TlXoUUfOVbF0TV2lgaq2sReIgtF2UrA9c2RAeazIPhytgoQpAPyEY369JDQkHNvayjcFaVKsXkbAuwASxnMkkI4wvyYiXOZt5TZjSw1UCxN1fFXpBdlPW6DxJd5wezs8_NoDeNqZCotI6eJ6Vag0mvNtrASymRpkgWZGs1U82gfYvm31opyLN1M-gNBkNcl2bn0Af2uhawi-UFMaMZHg1o3NJNjzMDt4ZRgWF-9P-fPya3AF7l2BOvtsjG8uw8PQEIs_RP8zr9C14v8TQ
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbhQxEC2FIFA2iK_SkCAjwbKh_Wu3FwglgShCCiCRkbJr-dcwIfSEyQSYHXfITXKQHIKTUHZPj9KCFVv_ZLlcrleq8iuApyUti8qGkLPAXC6cDnklBc_RFAlmENGaFC7Yf1fujcTbQ3m4An210cUBnv7TtYv1pEbT4-c_v81focK_jB4nuuwvxkdfT1nHzSavwXUmuIh3fV8s4wkIG6Tu0t7_mrEGNznCJDSjcmCbEoX_AHcOsyavmKHd23BrgR_JVifwO7AS2rtwo6soOb8HJymPhhwEQz6iXSLvx8ckFu5MFOGebF1e0N-_zgXLY8kOhy3by2_6xLSe7PTZROR1iNwSM_J9bAiCxDg1T5lzcZkvM_IBoeMPM78Po903Bzt7-aKoQu64KmRuCm55aRnX1AoXnJW2MY7JRvtC6bJijjrfUFY03NFSO29QpalTVCjtmXP8Aay2kzasA0F9t7zyzGhRiOCD0Q3iB3xCgwqMKZvBs_4465OOO6NGnyNKoL4qgQy241kvx0TG69QwmX6qFwpUKxkZSytvaRCiUTH7VXvtaMF55CviGWz0kqr7W1QzzuPH46oSGTxZdqMCxaiIacPkDMeg06sRxGiagRpIeLChYU87_pyouEvcFb7QD_975iNYQwiW4lNUbsDqbHoWNhHmzOzjdIP_ABwQ_0w
  priority: 102
  providerName: Scholars Portal
Title Green Tea Seed Oil Suppressed Aβ1–42-Induced Behavioral and Cognitive Deficit via the Aβ-Related Akt Pathway
URI https://www.proquest.com/docview/2333595884
https://search.proquest.com/docview/2210952191
https://pubmed.ncbi.nlm.nih.gov/PMC6514763
https://doaj.org/article/7514828db1e44f728229d9c103307813
Volume 20
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELbaIiQuiF8RWiIjwTHd-C-Oj92lS4W0ZQWttLfIdhwIdLOrdlvUG-_Am_AgPARPwthJVs2Viw-xE0UeT-ab-PM3CL3JSJbmxrmEOmoTbpVLcsFZAqGIUw2IVoftgtlpdnLOPyzEYgeJ_ixMIO1bUx82F8vDpv4auJXrpR31PLHRfDbJIMqDX4x20a5krE_RuyyLAaBvGe4M8vlR_W15RVvhNl-lhgEigogpBmEoqPUPIOaQIHkn4kwfoYcdVMRH7Ss9RjuueYLut8Ujb5-idaDM4DOn8WcIQfhjfYF9jc6gBl7ioz-_yd-fvzhNfHUOC1fG2xP5WDclnvTEIfzOeRmJDb6pNQY86G9NAknOP-b7Bs8BJf7Qt8_Q-fT4bHKSdPUTEstkKhKdMsMyQ5kihltnjTCVtlRUqkylynJqiS0rQtOKWZIpW2rwXmIlTK4qqbXsOdprVo17gTC4tmF5SbXiKXel06oCqABfSycdpdJE6G0_ncW6lckoIL3wFijuWiBCYz_X2zFe3DpcWF1-KToTF1J4cdK8NMRxXklPdFWlsiRlzEsTsQgd9JYqOo-7Kihj_oxxnvMIvd52g6_4DRDduNU1jIH8VgFeUSRCcmDhwQsNe2ARBtXtbtG9_O8799EDQFthK4qIA7S3ubx2rwDRbEwM63ghoc2n72N0b3x8Ov8Uh78DsY80AtoZz-Owzv8B90H-WQ
link.rule.ids 230,315,733,786,790,870,891,2115,2236,12083,12792,21416,24346,27955,27956,31752,31753,33406,33407,33777,33778,43343,43633,43838,53825,53827,74100,74390,74657
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NbtQwEB7BVoheEL8iUMBIcLQa_-THJ9QtrRZolwq2Um-R_wJLIbt0t6DeeAfehAfhIXgSxk52aS5cYyexxp6Zz57xNwDPcpanpfGecs8tlVZ5WmZSUHRFkmtEtDqGCw7H-ehYvj7JTroDt0WXVrmyidFQu5kNZ-TbXIhwh7Qs5Yv5VxqqRoXoaldC4ypsBMrNcgAbw73x0bv1lkvwWC6NoReieabyNvVd4EZ_e_rpy4K3jG5ZzylF7v4e4OynS17yP_s34UYHHMlOO9O34IpvbsO1tpTkxR2YxwQaMvGavEeHRN5OP5NQsTNygzuy8_sX-_Pjp-Q01Oqw-GS4vp9PdOPI7iqNiLz0gVRiSb5NNUF0GF6lMWUufOZ0SY4QM37XF3fheH9vsjuiXTUFakWRZlSnwojccKGYkdZbk5laW57VyqWFyktumXU142ktLMuVdRp1mdmCyUI5bq24B4Nm1vj7QFDRjSgd10qm0juvVY3AAW2nLzznhUng-Uqc1bwlzahwsxHEXl0WewLDIOt1n0B1HR_Mzj5UneZURRaoSktnmJeyLkLaq3LKslSIQFQkEthazVTV6d-i-rdaEni6bkbNCeEQ3fjZOfbB3a5C9KJYAkVvhnsD6rc004-RgzvHUaFpfvD_nz-B66PJ4UF18Gr85iFsItiKkSiWbcFgeXbuHyGgWZrH3ar9C_gK9Ys
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3LbtQwFLWgCMQG8RSBAkaCpTXxO16hPhiVV6lEK80u8itleGSGzhTUHf_An_AhfARfwrWTmTYbtraTWNe-vsfx8bkIPVNUlZWLkbDIPBHeRFJJwQmEIsEsIFqbjwve7au9I_F6Iic9_2nR0ypXa2JeqMPMp3_kI8Z5ukNaVWLU9LSIg93xi_k3kjJIpZPWPp3GZXQFomSZ0jjoyfnmi7OcOI1CPCJKGtWR4Dls-UfTT18XrNN2k4PwlFX8B9BzSJy8EInGN9GNHkLirW7Mb6FLsb2NrnZJJc_uoHmm0uDDaPEHCE34_fQLTrk7s0p4wFt_ftO_P38JRlLWDg8l2-ub-ti2Ae-sCEV4NyZ5iSX-PrUYcGJ6lGTyXHrN5yU-APT4w57dRUfjl4c7e6TPq0A816UktuSOK8e4oU746J10jfVMNiaU2qiKeepDQ1nZcE-V8cGCV1OvqdAmMO_5PbTRztp4H2FwecerwKwRpYghWtMAhIBVNOrImHYFer4yZz3v5DNq2HYks9cXzV6g7WTrdZskep0LZifHde9DtZZJtLQKjkYhGp0IsCYYT0vOk2QRL9DmaqTq3hMX9fm8KdDTdTX4UDoYsW2cnUIb2PcawDGGFkgPRnjQoWFNO_2Y1bgV9AoW6Qf___gTdA2ma_321f6bh-g6oK58JEXlJtpYnpzGR4Bslu5xnrL_AAFG-Eg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Green+Tea+Seed+Oil+Suppressed+A%CE%B21%E2%80%9342-Induced+Behavioral+and+Cognitive+Deficit+via+the+A%CE%B2-Related+Akt+Pathway&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Kim%2C+Jong+Min&rft.au=Park%2C+Seon+Kyeong&rft.au=Kang%2C+Jin+Yong&rft.au=Park%2C+Su+Bin&rft.date=2019-04-15&rft.pub=MDPI&rft.eissn=1422-0067&rft.volume=20&rft.issue=8&rft_id=info:doi/10.3390%2Fijms20081865&rft_id=info%3Apmid%2F30991755&rft.externalDBID=PMC6514763
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon