Correlation between plasma diphenhydramine level and sedative and antihistamine effects

• Published in: Clinical pharmacology and therapeutics Vol. 23; no. 4; p. 375
• Main Authors: Carruthers, S G, Shoeman, D W, Hignite, C E, Azarnoff, D L
• Format: Journal Article
• Language: English
• Published: United States 01.04.1978
• Subjects: Administration, Oral; Adult; Diphenhydramine - administration & dosage; Diphenhydramine - blood; Diphenhydramine - pharmacology; Female; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Injections, Intravenous; Male; Motor Skills - drug effects; Reaction Time - drug effects; Skin Tests

The sedative and antihistamine effects of diphenhydramine were assessed in relation to plasma concentration after placebo, diphenhydramine 50 mg intravenously, and diphenhydramine 50 mg orally to each of 6 healthy volunteers on three separate occasions. Diphenhydramine plasma elimination t1/2 was 3....