An Enzymatic Platform for Asymmetric Synthesis of Si‐Stereogenic Silanols

• Published in: Angewandte Chemie International Edition Vol. 64; no. 25; pp. e202501524 - n/a
• Main Authors: Dai, Shuang‐Yu, Chen, Xiahe, Yang, Yun‐Fang, Liu, Zhen
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 17.06.2025
• Edition: International ed. in English
• Subjects: Asymmetric synthesis; Asymmetry; Biocatalysis; Computational modeling; Directed evolution; Enantiomers; Oxidation; Pharmaceutical industry; Silanes; Silicon; Synthesis; Silicon; Biocatalysis; Directed evolution; Asymmetric synthesis; Computational modeling

Chiral silanols are important synthetic targets and have garnered increasing attention in the materials and pharmaceutical industries over recent decades. A promising approach for their efficient synthesis is asymmetric silane oxidation. While chemists have developed several transition‐metal‐catalyz...