Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2–Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology

• Published in: Journal of thoracic oncology Vol. 16; no. 11; pp. 1821 - 1839
• Main Authors: Stewart, C. Allison, Gay, Carl M., Ramkumar, Kavya, Cargill, Kasey R., Cardnell, Robert J., Nilsson, Monique B., Heeke, Simon, Park, Elizabeth M., Kundu, Samrat T., Diao, Lixia, Wang, Qi, Shen, Li, Xi, Yuanxin, Zhang, Bingnan, Della Corte, Carminia Maria, Fan, Youhong, Kundu, Kiran, Gao, Boning, Avila, Kimberley, Pickering, Curtis R., Johnson, Faye M., Zhang, Jianjun, Kadara, Humam, Minna, John D., Gibbons, Don L., Wang, Jing, Heymach, John V., Byers, Lauren Averett
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2021; International Association for the Study of Lung Cancer. Published by Elsevier Inc
• Subjects: ACE2; AXL; Bronchi; COVID-19; EMT; Humans; Lung; Lung Neoplasms; NSCLC; Original; Peptidyl-Dipeptidase A; SARS-CoV-2; ZEB1; ACE2; SARS-CoV-2; ZEB1; NSCLC; AXL; EMT

Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal and malignant models and tissues from the aerodigestive and respiratory trac...