Interleukin‐10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA

• Published in: European Journal of Immunology Vol. 36; no. 12; pp. 3248 - 3255
• Main Authors: Siewe, Lisa, Bollati–Fogolin, Mariela, Wickenhauser, Claudia, Krieg, Thomas, Müller, Werner, Roers, Axel
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag 01.12.2006
• Subjects: Adjuvants, Immunologic - administration & dosage; Animals; Cells, Cultured; CpG Islands - immunology; Cytokines; Inflammation; Inflammation Mediators - metabolism; Inflammation Mediators - physiology; Interleukin-10 - deficiency; Interleukin-10 - genetics; Interleukin-10 - physiology; Knock‐out mice; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - immunology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - immunology

Interleukin‐10 (IL‐10) is an important regulator of immune responses secreted by different cell types. We have previously shown that mice with selective inactivation of the IL‐10 gene in T cells suffer from deregulated T cell responses similar to those observed in IL‐10–/– animals. Unlike IL‐10–/– m...