α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells

• Published in: International journal of molecular sciences Vol. 23; no. 16; p. 9101
• Main Authors: Villanueva, José, Criado, Manuel, Giménez-Molina, Yolanda, González-Vélez, Virginia, Gil, Amparo, Gutiérrez, Luis Miguel
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 14.08.2022; MDPI
• Subjects: Acetylcholine receptors (nicotinic); Actin; Antibodies; Binding sites; Chromaffin cells; Confocal microscopy; Cytoskeleton; DBH; Exocytosis; Experiments; Hypotheses; Localization; Microscopy; Plasma; Protocol; Secretory component; secretory machinery; SNAP-25; SNAP-25 protein; α3β4 acetylcholine nicotinic receptor

The heteromeric assembly of α3 and β4 subunits of acetylcholine nicotinic receptors (nAChRs) seems to mediate the secretory response in bovine chromaffin cells. However, there is no information about the localization of these nAChRs in relationship with the secretory active zones in this cellular mo...