Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites - Wang, Wendy WeiWei; Khetani, Salman R.; Krzyzewski, Stacy; Duignan, David B.; Obach, R. Scott (Drug metabolism and disposition, 2010)
Keywords: Biological and medical sciences; Cells, Cultured; Chromatography, High Pressure Liquid; Coculture Techniques - methods; Cryopreservation; Hepatocytes - metabolism; Humans; Medical sciences; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; Models, Biological; Molecular Structure; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Pharmacology. Drug treatments; Predictive Value of Tests; Tandem Mass Spectrometry; CP-122721; HCM; CP-533536; ADME; CP-547632; CP-690550; CJ-13610; HPLC; Human; Drug; Evaluation; Mixed cell culture; Hepatocyte; Digestive system; Metabolite; Liver; In vitro