Vulnerability of the Dentate Gyrus to Aging and Intracerebroventricular Administration of Kainic Acid

• Published in: Experimental neurology Vol. 158; no. 2; pp. 491 - 503
• Main Authors: Shetty, Ashok K., Turner, Dennis A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.1999; Elsevier
• Subjects: aging; Aging - physiology; Animals; Biological and medical sciences; Cerebral Ventricles - drug effects; Cerebral Ventricles - growth & development; Cerebral Ventricles - physiology; dentate granule cells; dentate gyrus; Dentate Gyrus - cytology; Dentate Gyrus - drug effects; Dentate Gyrus - growth & development; dentate hilar cells; Development. Senescence. Regeneration. Transplantation; excitotoxic lesions; Fundamental and applied biological sciences. Psychology; Injections, Intraventricular; kainic acid; Kainic Acid - administration & dosage; Kainic Acid - pharmacology; Male; Neurons - cytology; Neurons - drug effects; Neurons - physiology; Rats; Rats, Inbred F344; Vertebrates: nervous system and sense organs; dentate hilar cells; dentate gyrus; excitotoxic lesions; kainic acid; aging; dentate granule cells; Senescence; Rat; Ageing; Rodentia; Vertebrata; Dentate gyrus; Mammalia; Animal; Excitatory aminoacid; Morphometry; Kainic acid; Age; Hippocampus

The hippocampal formation is highly vulnerable to the aging process, demonstrating functional alterations in circuitry with aging. Aging may also change the sensitivity of the hippocampal formation to excitotoxic lesions. In this study, using young adult, middle aged, and aged Fischer 344 rats, we e...