The dynamics of a simple, risk-structured HIV model

• Published in: Mathematical biosciences and engineering : MBE Vol. 17; no. 4; pp. 4184 - 4209
• Main Authors: Kot, Mark, Dimitrov, Dobromir T.
• Format: Journal Article
• Language: English
• Published: AIMS Press 15.06.2020
• Subjects: basic reproduction number; multi-compartment disease model; separable mixing
• ISSN: 1551-0018; 1551-0018
• DOI: 10.3934/mbe.2020232

Many diseases, such as HIV, are heterogeneous for risk. In this paper, we study an infectious-disease model for a population with demography, mass-action incidence, an arbitrary number of risk classes, and separable mixing. We complement our general analyses with two specific examples. In the first example, the mean of the components of the transmission coefficients decreases as we add more risk classes. In the second example, the mean stays constant but the variance decreases. For each example, we determine the disease-free equilibrium, the basic reproduction number, and the endemic equilibrium. We also characterize the spectrum of eigenvalues that determine the stability of the endemic equilibrium. For both examples, the basic reproduction number decreases as we add more risk classes. The endemic equilibrium, when present, is asymptotically stable. Our analyses suggest that risk structure must be modeled correctly, since different risk structures, with similar mean properties, can produce different dynamics.