Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions - Shirasaka, Yoshiyuki; Sager, Jennifer E; Lutz, Justin D; Davis, Connie; Isoherranen, Nina (Drug metabolism and disposition, 2013)
Keywords: Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Humans; Omeprazole - analogs & derivatives; Omeprazole - metabolism; Omeprazole - pharmacology; Cmax; FDA; Km; fu,p; OH-OMP; OMP-S; DDI; HLM; I; kdeg; C-OMP; AUC; LC-MS/MS; DM-OMP; kinact; OMP; IC50; EMA; TDI; P450; λ; fu,mic; Ki