Design of a Phase 2 Clinical Trial of an ASK1 Inhibitor, GS-4997, in Patients with Diabetic Kidney Disease - Lin, Joseph H.; Zhang, Jenny J.; Lin, Shao-Lee; Chertow, Glenn M. (Nephron, 2015)
Keywords: Adult; Aged; Albuminuria - drug therapy; Albuminuria - metabolism; Angiotensin II Type 1 Receptor Blockers - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Clinical Practice: Clinical Trial Protocol; Diabetes Mellitus, Type 2 - complications; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - physiopathology; Double-Blind Method; Drug Therapy, Combination; Female; Glomerular Filtration Rate - drug effects; Humans; Male; MAP Kinase Kinase Kinase 5 - antagonists & inhibitors; Middle Aged; Oxidative Stress - drug effects; Protein Kinase Inhibitors - administration & dosage; Protein Kinase Inhibitors - therapeutic use; eGFR; ARB; ASK1; ACEi; Phase 2; Albuminuria; GS-4997; DKD; Diabetic Kidney Disease; Proteinuria