Tenascin-C Is Highly Expressed in Respiratory Distress Syndrome and Bronchopulmonary Dysplasia

• Published in: The journal of histochemistry and cytochemistry Vol. 50; no. 3; pp. 423 - 431
• Main Authors: Kaarteenaho-Wiik, Riitta, Kinnula, Vuokko L, Herva, Riitta, Soini, Ylermi, Pollanen, Raimo, Paakko, Paavo
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Histochemical Soc 01.03.2002; SAGE Publications
• Subjects: Actins - analysis; Bronchi - chemistry; Bronchopulmonary Dysplasia - metabolism; Chondrocytes - chemistry; Epithelium - chemistry; Female; Gene Expression; Gestational Age; Humans; Immunohistochemistry; In Situ Hybridization; Infant, Newborn; Male; Pulmonary Alveoli - chemistry; Respiratory Distress Syndrome, Newborn - metabolism; RNA, Messenger - analysis; Tenascin - analysis; Tenascin - genetics; hyaline membrane disease; extracellular matrix

Tenascin-C is an extracellular matrix (ECM) glycoprotein expressed in human tissues during organogenesis and in fibrotic and neoplastic processes. We hypothesized that its expression would increase in human lung in neonatal disorders such as infant respiratory distress syndrome (RDS) and bronchopulm...