Clec9A + Dendritic Cells Are Not Essential for Antitumor CD8 + T Cell Responses Induced by Poly I:C Immunotherapy

• Published in: The Journal of immunology (1950) Vol. 200; no. 8; pp. 2978 - 2986
• Main Authors: Gilfillan, Connie B, Kuhn, Sabine, Baey, Camille, Hyde, Evelyn J, Yang, Jianping, Ruedl, Christiane, Ronchese, Franca
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 15.04.2018
• Subjects: Adaptive immunity; Animals; Antitumor activity; CD103 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell migration; Cross-Priming - immunology; Crystals; Cytotoxicity; Dendritic cells; Dendritic Cells - immunology; Depletion; Diphtheria; Diphtheria toxin; Female; Immune response; Immunotherapy; Immunotherapy - methods; Interferon Inducers - immunology; Lectins, C-Type - immunology; Lymph nodes; Lymphocytes; Lymphocytes T; Mammary gland; Mammary Neoplasms, Experimental - immunology; Melanoma; Melanoma, Experimental - immunology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid cells; Poly I-C - immunology; Polyinosinic:polycytidylic acid; Receptors, Immunologic - immunology; Rodents; Spleen; T cell receptors; Tumors; Uric acid

In the steady state, tumors harbor several populations of dendritic cells (DCs) and myeloid cells that are key regulators of the intratumoral immune environment. Among these cells, migratory CD103 cross-presenting DCs are thought to be critical for tumor-specific CTL responses and tumor resistance....