Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects

• Published in: The Journal of clinical investigation Vol. 98; no. 8; pp. 1755 - 1761
• Main Authors: Velho, G, Petersen, K F, Perseghin, G, Hwang, J H, Rothman, D L, Pueyo, M E, Cline, G W, Froguel, P, Shulman, G I
• Format: Journal Article
• Language: English
• Published: United States 15.10.1996
• Subjects: Adult; Diabetes Mellitus, Type 2 - metabolism; Glucokinase - deficiency; Glucokinase - genetics; Gluconeogenesis; Humans; Insulin - blood; Liver Glycogen - biosynthesis; Male; Middle Aged

All glucokinase gene mutations identified to date have been localized to exons that are common to the pancreatic and hepatic isoforms of the enzyme. While impaired insulin secretion has been observed in glucokinase-deficient subjects the consequences of this mutation on hepatic glucose metabolism re...