Low Transforming Growth Factor-β Pathway Activity in Cervical Adenocarcinomas

• Published in: Frontiers in oncology Vol. 12; p. 797453
• Main Authors: Marvin, Dieuwke L., Spaans, Vivian M., de Kroon, Cor D., Slieker, Roderick C., Khelil, Maryam, ten Dijke, Peter, Ritsma, Laila, Jordanova, Ekaterina S.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 08.06.2022
• Subjects: adenocarcinoma; cervical cancer; Oncology; SMAD4; squamous cell carcinoma; TGFBR2; transforming growth factor-β (TGF-β)

Cervical cancer is the fourth most common cancer in women worldwide. Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the most common histological types, with AC patients having worse prognosis. Over the last two decades, incidence rates of AC have increased, highlighting the importance of...