Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast

• Published in: Molecular biology of the cell Vol. 9; no. 7; pp. 1725 - 1739
• Main Authors: Roth, D, Guo, W, Novick, P
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 01.07.1998
• Subjects: Alleles; Fungal Proteins - biosynthesis; Fungal Proteins - genetics; Fungal Proteins - metabolism; Genes, Dominant; Genes, Fungal; Genes, Lethal - genetics; GTP-Binding Proteins - biosynthesis; GTP-Binding Proteins - metabolism; Mutagenesis, Site-Directed; Myosin Heavy Chains; Myosin Type V; Myosins - metabolism; Organelles - physiology; Peptide Fragments - biosynthesis; Peptide Fragments - genetics; Peptide Fragments - metabolism; Phenotype; rab GTP-Binding Proteins; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - physiology; Saccharomyces cerevisiae Proteins; Vesicular Transport Proteins

The accurate targeting of secretory vesicles to distinct sites on the plasma membrane is necessary to achieve polarized growth and to establish specialized domains at the surface of eukaryotic cells. Members of a protein complex required for exocytosis, the exocyst, have been localized to regions of...