Purified human plasma kallikrein aggregates human blood neutrophils

• Published in: The Journal of clinical investigation Vol. 69; no. 5; pp. 1199 - 1202
• Main Authors: Schapira, M, Despland, E, Scott, C F, Boxer, L A, Colman, R W
• Format: Journal Article
• Language: English
• Published: United States 01.05.1982
• Subjects: Cell Aggregation - drug effects; Humans; In Vitro Techniques; Kallikreins - blood; Kallikreins - pharmacology; Neutrophils - drug effects; Neutrophils - metabolism; Oxygen Consumption

Exposure of human blood polymorphonuclear leukocytes (PMN) to purified active plasma kallikrein resulted in PMN aggregation when kallikrein was present at concentrations ranging from 0.4 to 0.6 U/ml (0.18-0.27 microM). Kallikrein-induced PMN aggregation was not mediated through C5-derived peptides,...