Cyclooxygenase-2 Expression Is Related With Localization, Proliferation, and Overall Survival in Canine Melanocytic Neoplasms

• Published in: Veterinary pathology Vol. 48; no. 6; pp. 1204 - 1211
• Main Authors: Martínez, C. M., Peñafiel-Verdú, C., Vilafranca, M., Ramírez, G., Méndez-Gallego, M., Buendía, A. J., Sánchez, J.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.11.2011
• Subjects: analysis; Animals; biomarkers; Biomarkers, Tumor; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Cyclooxygenase 2; Cyclooxygenase 2 - analysis; Cyclooxygenase 2 - metabolism; Dog Diseases; Dog Diseases - mortality; Dog Diseases - pathology; Dog Diseases - surgery; Dogs; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; human behavior; Ki-67 Antigen; Ki-67 Antigen - analysis; Ki-67 Antigen - metabolism; Male; melanoma; Melanoma - mortality; Melanoma - pathology; Melanoma - surgery; Melanoma - veterinary; metabolism; metastasis; Mitotic Index; mortality; Mouth Neoplasms; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - surgery; Mouth Neoplasms - veterinary; pathology; regression analysis; Retrospective Studies; Skin Neoplasms; Skin Neoplasms - mortality; Skin Neoplasms - pathology; Skin Neoplasms - surgery; Skin Neoplasms - veterinary; surgery; Survival Analysis; T-lymphocytes; veterinary; melanoma; canine; prognosis; cyclooxygenase-2

A direct relationship has been firmly established between cyclooxygenase-2 (COX-2) expression and malignant behavior in human melanoma. This report examines the relationship between COX-2 expression and tumor location, mitotic and proliferative indices, degree of T CD3+ lymphocyte infiltration, over...