A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog
Introduction: Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic atrioventricular node—ablated, His bundle-paced Dog for defining drug induced cardiac repolarization prolongation. A novel predict...
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Published in | Journal of pharmacological and toxicological methods Vol. 53; no. 1; pp. 1 - 10 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
01.01.2006
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Abstract | Introduction: Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic atrioventricular node—ablated, His bundle-paced Dog for defining drug induced cardiac repolarization prolongation. A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation was generated from these data.
Methods: Three male beagle dogs underwent radiofrequency AV nodal ablation, and placement of a His bundle-pacing lead and programmable pacemaker under anesthesia. Each dog was restrained in a sling for a series of increasing dose infusions of each drug while maintained at a constant heart rate of 80 beats/min. RT interval, a surrogate for QT interval in His bundle-paced dogs, was recorded throughout the experiment.
Results: E-4031 induced a statistically significant RT prolongation at the highest three doses. Cisapride resulted in a dose-dependent increase in RT interval, which was statistically significant at the two highest doses. Terfenadine induced a dose-dependent RT interval prolongation with a statistically significant change occurring only at the highest dose. The relationship between drug concentration and RT interval change was described by a sigmoid
E
max model with an effect site. Maximum RT change (
E
max), free drug concentration at half of the maximum effect (EC
50), and free drug concentration associated with a 10 ms RT prolongation (EC
10 ms) were estimated. A linear correlation between EC
10 ms and HERG IC
50 values was identified.
Discussion: The conscious dog with His bundle-pacing detects delayed cardiac repolarization related to I
Kr inhibition, and detects repolarization change induced by drugs with activity at multiple ion channels. A clinically relevant sensitivity and a linear correlation with in vitro HERG data make the conscious His bundle-paced dog a valuable tool for detecting repolarization effect of new chemical entities. |
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AbstractList | Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic atrioventricular node--ablated, His bundle-paced Dog for defining drug induced cardiac repolarization prolongation. A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation was generated from these data.
Three male beagle dogs underwent radiofrequency AV nodal ablation, and placement of a His bundle-pacing lead and programmable pacemaker under anesthesia. Each dog was restrained in a sling for a series of increasing dose infusions of each drug while maintained at a constant heart rate of 80 beats/min. RT interval, a surrogate for QT interval in His bundle-paced dogs, was recorded throughout the experiment.
E-4031 induced a statistically significant RT prolongation at the highest three doses. Cisapride resulted in a dose-dependent increase in RT interval, which was statistically significant at the two highest doses. Terfenadine induced a dose-dependent RT interval prolongation with a statistically significant change occurring only at the highest dose. The relationship between drug concentration and RT interval change was described by a sigmoid E(max) model with an effect site. Maximum RT change (E(max)), free drug concentration at half of the maximum effect (EC(50)), and free drug concentration associated with a 10 ms RT prolongation (EC(10 ms)) were estimated. A linear correlation between EC(10 ms) and HERG IC(50) values was identified.
The conscious dog with His bundle-pacing detects delayed cardiac repolarization related to I(Kr) inhibition, and detects repolarization change induced by drugs with activity at multiple ion channels. A clinically relevant sensitivity and a linear correlation with in vitro HERG data make the conscious His bundle-paced dog a valuable tool for detecting repolarization effect of new chemical entities. Introduction: Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic atrioventricular node—ablated, His bundle-paced Dog for defining drug induced cardiac repolarization prolongation. A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation was generated from these data. Methods: Three male beagle dogs underwent radiofrequency AV nodal ablation, and placement of a His bundle-pacing lead and programmable pacemaker under anesthesia. Each dog was restrained in a sling for a series of increasing dose infusions of each drug while maintained at a constant heart rate of 80 beats/min. RT interval, a surrogate for QT interval in His bundle-paced dogs, was recorded throughout the experiment. Results: E-4031 induced a statistically significant RT prolongation at the highest three doses. Cisapride resulted in a dose-dependent increase in RT interval, which was statistically significant at the two highest doses. Terfenadine induced a dose-dependent RT interval prolongation with a statistically significant change occurring only at the highest dose. The relationship between drug concentration and RT interval change was described by a sigmoid E max model with an effect site. Maximum RT change ( E max), free drug concentration at half of the maximum effect (EC 50), and free drug concentration associated with a 10 ms RT prolongation (EC 10 ms) were estimated. A linear correlation between EC 10 ms and HERG IC 50 values was identified. Discussion: The conscious dog with His bundle-pacing detects delayed cardiac repolarization related to I Kr inhibition, and detects repolarization change induced by drugs with activity at multiple ion channels. A clinically relevant sensitivity and a linear correlation with in vitro HERG data make the conscious His bundle-paced dog a valuable tool for detecting repolarization effect of new chemical entities. Introduction: Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic atrioventricular node; ablated, His bundle-paced Dog for defining drug induced cardiac repolarization prolongation. A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation was generated from these data. Methods: Three male beagle dogs underwent radiofrequency AV nodal ablation, and placement of a His bundle-pacing lead and programmable pacemaker under anesthesia. Each dog was restrained in a sling for a series of increasing dose infusions of each drug while maintained at a constant heart rate of 80 beats/min. RT interval, a surrogate for QT interval in His bundle-paced dogs, was recorded throughout the experiment. Results: E- 4031 induced a statistically significant RT prolongation at the highest three doses. Cisapride resulted in a dose-dependent increase in RT interval, which was statistically significant at the two highest doses. Terfenadine induced a dose- dependent RT interval prolongation with a statistically significant change occurring only at the highest dose. The relationship between drug concentration and RT interval change was described by a sigmoid E sub(max) model with an effect site. Maximum RT change (E sub(max)), free drug concentration at half of the maximum effect (EC sub(50)), and free drug concentration associated with a 10 ms RT prolongation (EC sub(10 ms)) were estimated. A linear correlation between EC sub(10 ms) and HERG IC sub(50) values was identified. Discussion: The conscious dog with His bundle-pacing detects delayed cardiac repolarization related to I sub(Kr) inhibition, and detects repolarization change induced by drugs with activity at multiple ion channels. A clinically relevant sensitivity and a linear correlation with in vitro HERG data make the conscious His bundle- paced dog a valuable tool for detecting repolarization effect of new chemical entities. |
Author | Nolan, Emily R. Paulissen, Jerome B. Liu, Jing Feng, Meihua Rose Miller, Teresa Bailie, Marc B. Turluck, Daniel Olivier, N. Bari Zhang, Yiqun Koup, Jeffrey R. |
Author_xml | – sequence: 1 givenname: Emily R. surname: Nolan fullname: Nolan, Emily R. email: emily.nolan@pfizer.com organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 2 givenname: Meihua Rose surname: Feng fullname: Feng, Meihua Rose organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 3 givenname: Jeffrey R. surname: Koup fullname: Koup, Jeffrey R. organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 4 givenname: Jing surname: Liu fullname: Liu, Jing organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 5 givenname: Daniel surname: Turluck fullname: Turluck, Daniel organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 6 givenname: Yiqun surname: Zhang fullname: Zhang, Yiqun organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 7 givenname: Jerome B. surname: Paulissen fullname: Paulissen, Jerome B. organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 8 givenname: N. Bari surname: Olivier fullname: Olivier, N. Bari organization: Michigan State University College of Veterinary Medicine, East Lansing, MI, United States – sequence: 9 givenname: Teresa surname: Miller fullname: Miller, Teresa organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States – sequence: 10 givenname: Marc B. surname: Bailie fullname: Bailie, Marc B. organization: Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States |
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Cites_doi | 10.1016/S0009-9236(98)90137-0 10.1016/S0167-5273(97)00331-8 10.1007/BF01744586 10.1016/j.ejphar.2003.12.028 10.1080/00498250110054632 10.1023/A:1014460404352 10.1056/NEJMra032426 10.1046/j.1540-8167.2001.00411.x 10.1046/j.1540-8167.2003.03215.x 10.1046/j.1460-9592.2002.00209.x 10.1016/S0008-6363(02)00846-5 10.2165/00003088-200039010-00004 10.2165/00003495-199039040-00006 10.1097/00005344-199423030-00003 10.1111/j.1540-8159.2004.00664.x 10.1007/BF02691087 10.1097/00045391-200103000-00006 10.1136/hrt.55.3.253 10.1038/clpt.1991.206 10.1111/j.1365-2125.1981.tb01123.x 10.1016/S0735-1097(02)01852-1 10.1111/j.1540-8159.1999.tb00635.x 10.1111/j.1542-474X.2004.93533.x 10.1097/00005344-199511000-00013 10.1161/01.CIR.103.15.2004 10.1016/j.jelectrocard.2004.08.004 10.1124/jpet.102.035220 10.2165/00002018-199921001-00006 10.1001/jama.1993.03500120051025 10.1046/j.1472-8206.2002.00098.x |
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Keywords | QT interval Repolarization Cardiovascular His bundle-pacing Dog Methods Pharmacokinetic/pharmacodynamic modeling |
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References | Fujiki, Tani, Mizumake, Shimono, Inhoue (bib7) 1994; 23 Redfern, Wakefield, Prior, Pollard, Hammond, Valentin (bib26) 2002; 16 Roden (bib27) 2004; 350 Olivier, Eyster, Sanders, Cheng, Bohart, Girand (bib23) 2003; 14 Gras, Llenas (bib9) 1999; 21 Gladziwa, Bares, Klotz, Dakshinamurty, Ittel, Seiler (bib8) 1991; 50 McTavish, Goa, Ferrill (bib19) 1990; 39 Yelamanchi, Molnar, Ranade, Somberg (bib32) 2001; 8 Ming, Nordin (bib22) 1995; 26 Minematsu, Ohtani, Yamada, Sawada, Sato, Iga (bib21) 2001; 6 Sanders, Bailie, Olivier (bib28) 2004; 27 Lainee, Perez, Dubreuil, Gillet (bib15) 1998; 26 Fossa, Depasquale, Raunig, Avery, Leishman (bib5) 2002; 202 Holford, Coates, Guentert, Riegelman, Sheiner (bib10) 1981; 11 Hondeghem, Carlsson, Duker (bib11) 2001; 103 Chiladakis, Karapanos, Manolis (bib4) 1998; 64 Redfern, Carlsson, Davis, Lynch, MacKenzie, Palethorpe (bib25) 2003; 58 Aytemir, Maarouf, Gallager, Yap, Waktare, Malik (bib2) 1999; 22 Huang, Hull, Foreman, Lazzara, Wolf (bib13) 1992; 27 Fossa, Wisialowski, Wolfgang, Wang, Avery, Raunig (bib6) 2004; 486 Antzelevitch (bib1) 2004; 37 Khan, Nair (bib14) 2004; 9 Malik (bib18) 2002; 25 Usui, Sugiyama, Ishida, Satoh, Sasaki, Hashimoto (bib29) 1998; 13 Van Haarst, Van't Klooster, Van Gerven, Schoemaker, Van Oene, Burggraaf (bib30) 1998; 64 Webster, Allan, Anto-Awuakye, Harrison, Kidd, Leishman (bib31) 2001; 31 Michalets, Williams (bib20) 2000; 39 Bexton, Vallin, Camm (bib3) 1986; 55 Oto, Breithardt (bib24) 2001 Honig, Wortham, Zamani, Conner, Mullin, Cantilena (bib12) 1993; 269 Magnano, Holleran, Ramakrishnan, Reiffel, Bloomfield (bib16) 2002; 39 Malik (bib17) 2001; 12 Olivier (10.1016/j.vascn.2005.02.003_bib23) 2003; 14 Sanders (10.1016/j.vascn.2005.02.003_bib28) 2004; 27 Bexton (10.1016/j.vascn.2005.02.003_bib3) 1986; 55 Chiladakis (10.1016/j.vascn.2005.02.003_bib4) 1998; 64 Redfern (10.1016/j.vascn.2005.02.003_bib25) 2003; 58 Oto (10.1016/j.vascn.2005.02.003_bib24) 2001 Roden (10.1016/j.vascn.2005.02.003_bib27) 2004; 350 Aytemir (10.1016/j.vascn.2005.02.003_bib2) 1999; 22 Hondeghem (10.1016/j.vascn.2005.02.003_bib11) 2001; 103 Malik (10.1016/j.vascn.2005.02.003_bib18) 2002; 25 Gras (10.1016/j.vascn.2005.02.003_bib9) 1999; 21 Usui (10.1016/j.vascn.2005.02.003_bib29) 1998; 13 Lainee (10.1016/j.vascn.2005.02.003_bib15) 1998; 26 Michalets (10.1016/j.vascn.2005.02.003_bib20) 2000; 39 Antzelevitch (10.1016/j.vascn.2005.02.003_bib1) 2004; 37 Gladziwa (10.1016/j.vascn.2005.02.003_bib8) 1991; 50 Khan (10.1016/j.vascn.2005.02.003_bib14) 2004; 9 Malik (10.1016/j.vascn.2005.02.003_bib17) 2001; 12 Redfern (10.1016/j.vascn.2005.02.003_bib26) 2002; 16 Yelamanchi (10.1016/j.vascn.2005.02.003_bib32) 2001; 8 Fossa (10.1016/j.vascn.2005.02.003_bib6) 2004; 486 Holford (10.1016/j.vascn.2005.02.003_bib10) 1981; 11 Van Haarst (10.1016/j.vascn.2005.02.003_bib30) 1998; 64 Fossa (10.1016/j.vascn.2005.02.003_bib5) 2002; 202 Minematsu (10.1016/j.vascn.2005.02.003_bib21) 2001; 6 Ming (10.1016/j.vascn.2005.02.003_bib22) 1995; 26 Huang (10.1016/j.vascn.2005.02.003_bib13) 1992; 27 Magnano (10.1016/j.vascn.2005.02.003_bib16) 2002; 39 McTavish (10.1016/j.vascn.2005.02.003_bib19) 1990; 39 Webster (10.1016/j.vascn.2005.02.003_bib31) 2001; 31 Honig (10.1016/j.vascn.2005.02.003_bib12) 1993; 269 Fujiki (10.1016/j.vascn.2005.02.003_bib7) 1994; 23 |
References_xml | – volume: 55 start-page: 253 year: 1986 end-page: 258 ident: bib3 article-title: Diurnal variation of the QT interval—influence of the autonomic nervous system publication-title: British Heart Journal contributor: fullname: Camm – volume: 486 start-page: 209 year: 2004 end-page: 221 ident: bib6 article-title: Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig publication-title: European Journal of Pharmacology contributor: fullname: Raunig – volume: 11 start-page: 187 year: 1981 end-page: 195 ident: bib10 article-title: The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: Concentration—effects relationships publication-title: British Journal of Clinical Pharmacology contributor: fullname: Sheiner – volume: 26 start-page: 761 year: 1995 end-page: 769 ident: bib22 article-title: Terfenadine blocks time-dependent Ca publication-title: Journal of Cardiovascular Pharmacology contributor: fullname: Nordin – volume: 64 start-page: 542 year: 1998 end-page: 546 ident: bib30 article-title: The influence of cisapride and clarithromycin on QT intervals in healthy volunteers publication-title: Clinical Pharmacology and Therapeutics contributor: fullname: Burggraaf – start-page: 151 year: 2001 end-page: 170 ident: bib24 publication-title: Myocardial Repolarization contributor: fullname: Breithardt – volume: 31 start-page: 633 year: 2001 end-page: 650 ident: bib31 article-title: Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog publication-title: Xenobiotica contributor: fullname: Leishman – volume: 39 start-page: 552 year: 1990 end-page: 574 ident: bib19 article-title: Terfenadine—An updated review of its pharmacological properties and therapeutic efficacy publication-title: Drugs contributor: fullname: Ferrill – volume: 39 start-page: 49 year: 2000 end-page: 75 ident: bib20 article-title: Drug interactions with cisapride. Clinical implications publication-title: Clinical Pharmacokinetics contributor: fullname: Williams – volume: 6 start-page: 533 year: 2001 end-page: 554 ident: bib21 article-title: Quantitative relationship between myocardial concentration of tacrolimus and QT prolongation in guinea pigs: Pharmacodynamic model incorporating a site of adverse effect publication-title: Journal of Pharmacokinetics and Pharmacodynamics contributor: fullname: Iga – volume: 269 start-page: 1513 year: 1993 end-page: 1518 ident: bib12 article-title: Terfenadine–ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences publication-title: Journal of the American Medical Association contributor: fullname: Cantilena – volume: 37 start-page: 15 year: 2004 end-page: 24 ident: bib1 article-title: Arrhythmogenic mechanisms of QT prolonging drugs: Is QT prolongation really the problem? publication-title: Journal of Electrocardiology contributor: fullname: Antzelevitch – volume: 23 start-page: 374 year: 1994 end-page: 378 ident: bib7 article-title: Electrophysiologic effects of intravenous E-4031, a novel class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias publication-title: Journal of Cardiovascular Pharmacology contributor: fullname: Inhoue – volume: 21 start-page: 39 year: 1999 end-page: 44 ident: bib9 article-title: Effects of H1 antihistamines on animal models of QTc prolongation publication-title: Drug Safety contributor: fullname: Llenas – volume: 27 start-page: 6 year: 1992 end-page: 12 ident: bib13 article-title: Heart rate—QT relationships during baroreceptor stimulation with diminished autonomic influence on the ventricles publication-title: Integrative Physiological and Behavioral Science contributor: fullname: Wolf – volume: 26 start-page: S807 year: 1998 end-page: S817 ident: bib15 article-title: Electrocardiographic effects of mizolastine and terfenadine in conscious dogs publication-title: Japanese Pharmacology & Therapeutics contributor: fullname: Gillet – volume: 202 start-page: 828 year: 2002 end-page: 833 ident: bib5 article-title: The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT–RR interval assessment publication-title: Journal of Pharmacology and Experimental Therapeutics contributor: fullname: Leishman – volume: 9 start-page: 280 year: 2004 end-page: 289 ident: bib14 article-title: Brugada and long QT-3 syndromes: Two phenotypes of the sodium channel disease publication-title: Annals of Noninvasive Electrocardiology contributor: fullname: Nair – volume: 58 start-page: 32 year: 2003 end-page: 45 ident: bib25 article-title: Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and Torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development publication-title: Cardiovascular Research contributor: fullname: Palethorpe – volume: 103 start-page: 2004 year: 2001 end-page: 2013 ident: bib11 article-title: Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic publication-title: Circulation contributor: fullname: Duker – volume: 8 start-page: 117 year: 2001 end-page: 122 ident: bib32 article-title: Influence of electrolyte abnormalities on interlead variability of ventricular repolarization times in 12-lead electrocardiography publication-title: American Journal of Therapeutics contributor: fullname: Somberg – volume: 14 start-page: 1356 year: 2003 end-page: 1360 ident: bib23 article-title: Atrioventricular nodal ablation and His-Bundle pacing: An acute model for proarrhythmic risk assessment publication-title: Journal of Cardiovascular Electrophysiology contributor: fullname: Girand – volume: 13 start-page: 49 year: 1998 end-page: 57 ident: bib29 article-title: Simultaneous assessment of the hemodynamic, cardiomechanical, and electrophysiological effects of terfenadine on the in vivo canine model publication-title: Heart and Vessels contributor: fullname: Hashimoto – volume: 16 start-page: 161 year: 2002 end-page: 173 ident: bib26 article-title: Safety pharmacology—A progressive approach publication-title: Fundamental and Clinical Pharmacology contributor: fullname: Valentin – volume: 50 start-page: 673 year: 1991 end-page: 681 ident: bib8 article-title: Pharmacokinetics and pharmacodynamics of cisapride in patients undergoing hemodialysis publication-title: Clinical Pharmacology and Therapeutics contributor: fullname: Seiler – volume: 22 start-page: 1397 year: 1999 end-page: 1401 ident: bib2 article-title: Comparison of formulae for heart rate correction of QT interval in exercise electrocardiograms publication-title: Pacing and Clinical Electrophysiology contributor: fullname: Malik – volume: 350 start-page: 1013 year: 2004 end-page: 1022 ident: bib27 article-title: Drug-induced prolongation of the QT interval publication-title: The New England Journal of Medicine contributor: fullname: Roden – volume: 12 start-page: 411 year: 2001 end-page: 420 ident: bib17 article-title: Problems of heart rate correction in assessment of drug-induced QT interval prolongation publication-title: Journal of Cardiovascular Electrophysiology contributor: fullname: Malik – volume: 25 start-page: 209 year: 2002 end-page: 216 ident: bib18 article-title: The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes publication-title: Pacing and Clinical Electrophysiology contributor: fullname: Malik – volume: 39 start-page: 1820 year: 2002 end-page: 1826 ident: bib16 article-title: Autonomic nervous system influences on QT interval in normal subjects publication-title: Journal of the American College of Cardiology contributor: fullname: Bloomfield – volume: 27 start-page: 1475 year: 2004 end-page: 1483 ident: bib28 article-title: Stability of ventricular repolarization in conscious dogs with chronic atrioventricular dissociation and His-Bundle pacing publication-title: Pacing and Clinical Electrophysiology contributor: fullname: Olivier – volume: 64 start-page: 93 year: 1998 end-page: 95 ident: bib4 article-title: Idiopathic long QT syndrome with late onset of bradycardia-dependent and short-coupled variant of torsade de pointes publication-title: International Journal of Cardiology contributor: fullname: Manolis – volume: 64 start-page: 542 year: 1998 ident: 10.1016/j.vascn.2005.02.003_bib30 article-title: The influence of cisapride and clarithromycin on QT intervals in healthy volunteers publication-title: Clinical Pharmacology and Therapeutics doi: 10.1016/S0009-9236(98)90137-0 contributor: fullname: Van Haarst – volume: 64 start-page: 93 issue: 1 year: 1998 ident: 10.1016/j.vascn.2005.02.003_bib4 article-title: Idiopathic long QT syndrome with late onset of bradycardia-dependent and short-coupled variant of torsade de pointes publication-title: International Journal of Cardiology doi: 10.1016/S0167-5273(97)00331-8 contributor: fullname: Chiladakis – volume: 13 start-page: 49 year: 1998 ident: 10.1016/j.vascn.2005.02.003_bib29 article-title: Simultaneous assessment of the hemodynamic, cardiomechanical, and electrophysiological effects of terfenadine on the in vivo canine model publication-title: Heart and Vessels doi: 10.1007/BF01744586 contributor: fullname: Usui – volume: 486 start-page: 209 year: 2004 ident: 10.1016/j.vascn.2005.02.003_bib6 article-title: Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig publication-title: European Journal of Pharmacology doi: 10.1016/j.ejphar.2003.12.028 contributor: fullname: Fossa – volume: 31 start-page: 633 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib31 article-title: Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog publication-title: Xenobiotica doi: 10.1080/00498250110054632 contributor: fullname: Webster – volume: 6 start-page: 533 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib21 article-title: Quantitative relationship between myocardial concentration of tacrolimus and QT prolongation in guinea pigs: Pharmacodynamic model incorporating a site of adverse effect publication-title: Journal of Pharmacokinetics and Pharmacodynamics doi: 10.1023/A:1014460404352 contributor: fullname: Minematsu – volume: 350 start-page: 1013 issue: 10 year: 2004 ident: 10.1016/j.vascn.2005.02.003_bib27 article-title: Drug-induced prolongation of the QT interval publication-title: The New England Journal of Medicine doi: 10.1056/NEJMra032426 contributor: fullname: Roden – volume: 26 start-page: S807 year: 1998 ident: 10.1016/j.vascn.2005.02.003_bib15 article-title: Electrocardiographic effects of mizolastine and terfenadine in conscious dogs publication-title: Japanese Pharmacology & Therapeutics contributor: fullname: Lainee – volume: 12 start-page: 411 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib17 article-title: Problems of heart rate correction in assessment of drug-induced QT interval prolongation publication-title: Journal of Cardiovascular Electrophysiology doi: 10.1046/j.1540-8167.2001.00411.x contributor: fullname: Malik – volume: 14 start-page: 1356 year: 2003 ident: 10.1016/j.vascn.2005.02.003_bib23 article-title: Atrioventricular nodal ablation and His-Bundle pacing: An acute model for proarrhythmic risk assessment publication-title: Journal of Cardiovascular Electrophysiology doi: 10.1046/j.1540-8167.2003.03215.x contributor: fullname: Olivier – volume: 25 start-page: 209 year: 2002 ident: 10.1016/j.vascn.2005.02.003_bib18 article-title: The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes publication-title: Pacing and Clinical Electrophysiology doi: 10.1046/j.1460-9592.2002.00209.x contributor: fullname: Malik – volume: 58 start-page: 32 year: 2003 ident: 10.1016/j.vascn.2005.02.003_bib25 article-title: Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and Torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development publication-title: Cardiovascular Research doi: 10.1016/S0008-6363(02)00846-5 contributor: fullname: Redfern – volume: 39 start-page: 49 issue: 1 year: 2000 ident: 10.1016/j.vascn.2005.02.003_bib20 article-title: Drug interactions with cisapride. Clinical implications publication-title: Clinical Pharmacokinetics doi: 10.2165/00003088-200039010-00004 contributor: fullname: Michalets – volume: 39 start-page: 552 year: 1990 ident: 10.1016/j.vascn.2005.02.003_bib19 article-title: Terfenadine—An updated review of its pharmacological properties and therapeutic efficacy publication-title: Drugs doi: 10.2165/00003495-199039040-00006 contributor: fullname: McTavish – volume: 23 start-page: 374 year: 1994 ident: 10.1016/j.vascn.2005.02.003_bib7 article-title: Electrophysiologic effects of intravenous E-4031, a novel class III antiarrhythmic agent, in patients with supraventricular tachyarrhythmias publication-title: Journal of Cardiovascular Pharmacology doi: 10.1097/00005344-199423030-00003 contributor: fullname: Fujiki – volume: 27 start-page: 1475 year: 2004 ident: 10.1016/j.vascn.2005.02.003_bib28 article-title: Stability of ventricular repolarization in conscious dogs with chronic atrioventricular dissociation and His-Bundle pacing publication-title: Pacing and Clinical Electrophysiology doi: 10.1111/j.1540-8159.2004.00664.x contributor: fullname: Sanders – volume: 27 start-page: 6 issue: 1 year: 1992 ident: 10.1016/j.vascn.2005.02.003_bib13 article-title: Heart rate—QT relationships during baroreceptor stimulation with diminished autonomic influence on the ventricles publication-title: Integrative Physiological and Behavioral Science doi: 10.1007/BF02691087 contributor: fullname: Huang – volume: 8 start-page: 117 issue: 2 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib32 article-title: Influence of electrolyte abnormalities on interlead variability of ventricular repolarization times in 12-lead electrocardiography publication-title: American Journal of Therapeutics doi: 10.1097/00045391-200103000-00006 contributor: fullname: Yelamanchi – volume: 55 start-page: 253 year: 1986 ident: 10.1016/j.vascn.2005.02.003_bib3 article-title: Diurnal variation of the QT interval—influence of the autonomic nervous system publication-title: British Heart Journal doi: 10.1136/hrt.55.3.253 contributor: fullname: Bexton – volume: 50 start-page: 673 issue: 6 year: 1991 ident: 10.1016/j.vascn.2005.02.003_bib8 article-title: Pharmacokinetics and pharmacodynamics of cisapride in patients undergoing hemodialysis publication-title: Clinical Pharmacology and Therapeutics doi: 10.1038/clpt.1991.206 contributor: fullname: Gladziwa – volume: 11 start-page: 187 year: 1981 ident: 10.1016/j.vascn.2005.02.003_bib10 article-title: The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: Concentration—effects relationships publication-title: British Journal of Clinical Pharmacology doi: 10.1111/j.1365-2125.1981.tb01123.x contributor: fullname: Holford – volume: 39 start-page: 1820 year: 2002 ident: 10.1016/j.vascn.2005.02.003_bib16 article-title: Autonomic nervous system influences on QT interval in normal subjects publication-title: Journal of the American College of Cardiology doi: 10.1016/S0735-1097(02)01852-1 contributor: fullname: Magnano – start-page: 151 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib24 contributor: fullname: Oto – volume: 22 start-page: 1397 year: 1999 ident: 10.1016/j.vascn.2005.02.003_bib2 article-title: Comparison of formulae for heart rate correction of QT interval in exercise electrocardiograms publication-title: Pacing and Clinical Electrophysiology doi: 10.1111/j.1540-8159.1999.tb00635.x contributor: fullname: Aytemir – volume: 9 start-page: 280 issue: 3 year: 2004 ident: 10.1016/j.vascn.2005.02.003_bib14 article-title: Brugada and long QT-3 syndromes: Two phenotypes of the sodium channel disease publication-title: Annals of Noninvasive Electrocardiology doi: 10.1111/j.1542-474X.2004.93533.x contributor: fullname: Khan – volume: 26 start-page: 761 year: 1995 ident: 10.1016/j.vascn.2005.02.003_bib22 article-title: Terfenadine blocks time-dependent Ca2+, Na+ and K+ channels in guinea pig ventricular myocytes publication-title: Journal of Cardiovascular Pharmacology doi: 10.1097/00005344-199511000-00013 contributor: fullname: Ming – volume: 103 start-page: 2004 year: 2001 ident: 10.1016/j.vascn.2005.02.003_bib11 article-title: Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic publication-title: Circulation doi: 10.1161/01.CIR.103.15.2004 contributor: fullname: Hondeghem – volume: 37 start-page: 15 year: 2004 ident: 10.1016/j.vascn.2005.02.003_bib1 article-title: Arrhythmogenic mechanisms of QT prolonging drugs: Is QT prolongation really the problem? publication-title: Journal of Electrocardiology doi: 10.1016/j.jelectrocard.2004.08.004 contributor: fullname: Antzelevitch – volume: 202 start-page: 828 year: 2002 ident: 10.1016/j.vascn.2005.02.003_bib5 article-title: The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT–RR interval assessment publication-title: Journal of Pharmacology and Experimental Therapeutics doi: 10.1124/jpet.102.035220 contributor: fullname: Fossa – volume: 21 start-page: 39 issue: Supplement 1 year: 1999 ident: 10.1016/j.vascn.2005.02.003_bib9 article-title: Effects of H1 antihistamines on animal models of QTc prolongation publication-title: Drug Safety doi: 10.2165/00002018-199921001-00006 contributor: fullname: Gras – volume: 269 start-page: 1513 year: 1993 ident: 10.1016/j.vascn.2005.02.003_bib12 article-title: Terfenadine–ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences publication-title: Journal of the American Medical Association doi: 10.1001/jama.1993.03500120051025 contributor: fullname: Honig – volume: 16 start-page: 161 year: 2002 ident: 10.1016/j.vascn.2005.02.003_bib26 article-title: Safety pharmacology—A progressive approach publication-title: Fundamental and Clinical Pharmacology doi: 10.1046/j.1472-8206.2002.00098.x contributor: fullname: Redfern |
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Snippet | Introduction: Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the... Terfenadine, cisapride, and E-4031, three drugs that prolong ventricular repolarization, were selected to evaluate the sensitivity of the conscious chronic... |
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SubjectTerms | Animals Anti-Arrhythmia Agents - blood Anti-Arrhythmia Agents - pharmacokinetics Anti-Arrhythmia Agents - toxicity Atrioventricular Node - surgery Bundle of His - surgery Cardiac Pacing, Artificial Cardiovascular Catheter Ablation Cisapride - blood Cisapride - pharmacokinetics Cisapride - toxicity Dog Dogs Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Electrocardiography - drug effects Gastrointestinal Agents - blood Gastrointestinal Agents - pharmacokinetics Gastrointestinal Agents - toxicity His bundle-pacing Histamine H1 Antagonists - blood Histamine H1 Antagonists - pharmacokinetics Histamine H1 Antagonists - toxicity Ion Channels - antagonists & inhibitors Long QT Syndrome - etiology Male Methods Models, Animal Models, Biological Pharmacokinetic/pharmacodynamic modeling Piperidines - blood Piperidines - pharmacokinetics Piperidines - toxicity Pyridines - blood Pyridines - pharmacokinetics Pyridines - toxicity QT interval Repolarization Terfenadine - blood Terfenadine - pharmacokinetics Terfenadine - toxicity |
Title | A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog |
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