A Pilot, Prospective, Observational Study to Investigate the Value of NGS in Liquid Biopsies to Predict Tumor Response After Neoadjuvant Chemo-Radiotherapy in Patients With Locally Advanced Rectal Cancer: The LiBReCa Study

• Published in: Frontiers in oncology Vol. 12; p. 900945
• Main Authors: Roesel, Raffaello, Epistolio, Samantha, Molinari, Francesca, Saletti, Piercarlo, De Dosso, Sara, Valli, Mariacarla, Franzetti-Pellanda, Alessandra, Deantonio, Letizia, Biggiogero, Maira, Spina, Paolo, Popeskou, Sotirios Georgios, Cristaudi, Alessandra, Mongelli, Francesco, Mazzucchelli, Luca, Stefanini, Federico Mattia, Frattini, Milo, Christoforidis, Dimitri
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 28.06.2022
• Subjects: circulating tumor DNA (ctDNA); LARC; liquid biopsy; next-generation sequencing; Oncology; rectal cancer (RC); watch and wait approach

Introduction Circulating tumor DNA (ctDNA) correlates with the response to therapy in different types of cancer. However, in patients with locally advanced rectal cancer (LARC), little is known about how ctDNA levels change with neoadjuvant chemoradiation (Na-ChRT) and how they correlate with treatm...