Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases

• Published in: Clinical cancer research Vol. 10; no. 20; pp. 6897 - 6904
• Main Authors: Allard, W. Jeffrey, Matera, Jeri, Miller, M. Craig, Repollet, Madeline, Connelly, Mark C., Rao, Chandra, Tibbe, Arjan G. J., Uhr, Jonathan W., Terstappen, Leon W. M. M.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.10.2004
• Subjects: Adult; Antineoplastic agents; Automation; Biological and medical sciences; Biological Assay; Carcinoma - pathology; Case-Control Studies; Cytological Techniques; Female; Humans; Male; Medical sciences; Middle Aged; Neoplasm Metastasis; Neoplastic Cells, Circulating; Pharmacology. Drug treatments; Reproducibility of Results; Sensitivity and Specificity; Tumors; Human; Biological fluid; Carcinoma; Healthy subject; Malignant tumor; Tumor cell; Blood

Purpose: The purpose of this study was to determine the accuracy, precision, and linearity of the CellSearch system and evaluate the number of circulating tumor cells (CTCs) per 7.5 mL of blood in healthy subjects, patients with nonmalignant diseases, and patients with a variety of metastatic carcin...