Imbalances of gamma globulin subgroups and gene defects in patients with primary hypogammaglobulinemia

• Published in: The Journal of clinical investigation Vol. 49; no. 11; pp. 1957 - 1966
• Main Authors: Yount, W J, Seligmann, M, Hong, R, Good, R, Kunkel, H G
• Format: Journal Article
• Language: English
• Published: United States 01.11.1970
• Subjects: Adolescent; Adult; Agammaglobulinemia - genetics; Alleles; Bence Jones Protein - isolation & purification; Child, Preschool; Electrophoresis, Disc; Female; gamma-Globulins - classification; Genes; Genes, Dominant; Genes, Regulator; Hemagglutination Inhibition Tests; Heterozygote; Homozygote; Humans; Immune Sera; Immunoelectrophoresis; Immunoglobulin G; Immunoglobulins; Infant; Male; Pedigree; Precipitin Tests

Analysis of immunoglobulin classes, gammaG subgroups, and Gm genetic markers from 59 patients with various types of immune deficiencies was undertaken to assess the function of the several cistrons concerned with synthesis of gamma globulins. 13 patients including two sibling pairs were found to hav...