Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors

• Published in: Stem cells (Dayton, Ohio) Vol. 41; no. 10; pp. 944 - 957
• Main Authors: Wang, Zhengqi, Emmel, Grace, Lim, Hong Seo, Zhu, Wandi, Kosters, Astrid, Ghosn, Eliver E B, Qiu, Peng, Bunting, Kevin D
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 08.10.2023
• Subjects: Animals; Bone Marrow - metabolism; Hematopoiesis - genetics; Hematopoietic Stem Cells - metabolism; Mice; Mice, Knockout; Mice, Transgenic; STAT5 Transcription Factor - genetics; STAT5 Transcription Factor - metabolism; Stem Cell Niche - physiology; single-cell RNA sequencing; cytokine signaling; mesenchymal stem cell; hematopoiesis; signal transducer and activator of transcription-5; bone marrow niche factors

Abstract Signal transducer and activator of transcription 5 (STAT5a and STAT5b) are intrinsically critical for normal hematopoiesis but are also expressed in stromal cells. Here, STAT5ab knockout (KO) was generated with a variety of bone marrow hematopoietic and stromal Cre transgenic mouse strains....