Automated Diagnosis of COVID-19 Using Deep Supervised Autoencoder With Multi-View Features From CT Images

• Published in: IEEE/ACM transactions on computational biology and bioinformatics Vol. 19; no. 5; pp. 2723 - 2736
• Main Authors: Cheng, Jianhong, Zhao, Wei, Liu, Jin, Xie, Xingzhi, Wu, Shangjie, Liu, Liangliang, Yue, Hailin, Li, Junjian, Wang, Jianxin, Liu, Jun
• Format: Journal Article
• Language: English
• Published: New York IEEE 01.09.2022; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Computed tomography; Coronaviruses; COVID-19; deep supervised autoencoder; Diagnosis; Diagnostic software; Feature extraction; Hospitals; Lesions; Medical imaging; multi-task learning; multi-view features; Patients; Pneumonia; Pulmonary diseases; Three-dimensional displays; Viral diseases
• ISSN: 1545-5963; 1557-9964; 1557-9964
• DOI: 10.1109/TCBB.2021.3102584

Accurate and rapid diagnosis of coronavirus disease 2019 (COVID-19) from chest CT scans is of great importance and urgency during the worldwide outbreak. However, radiologists have to distinguish COVID-19 pneumonia from other pneumonia in a large number of CT scans, which is tedious and inefficient. Thus, it is urgently and clinically needed to develop an efficient and accurate diagnostic tool to help radiologists to fulfill the difficult task. In this study, we proposed a deep supervised autoencoder (DSAE) framework to automatically identify COVID-19 using multi-view features extracted from CT images. To fully explore features characterizing CT images from different frequency domains, DSAE was proposed to learn the latent representation by multi-task learning. The proposal was designed to both encode valuable information from different frequency features and construct a compact class structure for separability. To achieve this, we designed a multi-task loss function, which consists of a supervised loss and a reconstruction loss. Our proposed method was evaluated on a newly collected dataset of 787 subjects including COVID-19 pneumonia patients, other pneumonia patients, and normal subjects without abnormal CT findings. Extensive experimental results demonstrated that our proposed method achieved encouraging diagnostic performance and may have potential clinical application for the diagnosis of COVID-19.