The problem of anaphylaxis and mastocytosis

• Published in: Current allergy and asthma reports Vol. 9; no. 1; pp. 64 - 70
• Main Authors: Müller, Ulrich R., Haeberli, Gabrielle
• Format: Journal Article
• Language: English
• Published: New York Current Science Inc 2009; Springer Nature B.V
• Subjects: Allergies; Allergology; Anaphylaxis - etiology; Anaphylaxis - immunology; Anaphylaxis - prevention & control; Animals; Anti-Allergic Agents - therapeutic use; Arthropod Venoms - immunology; Humans; Hymenoptera - immunology; Mast Cells - immunology; Mastocytosis - complications; Mastocytosis - drug therapy; Mastocytosis - immunology; Medicine; Medicine & Public Health; Tryptases - blood; Tryptases - immunology; World Allergy Organization; Systemic Mastocytosis; Mastocytosis; Allergy Clin Immunol; Hymenoptera Venom

Mastocytosis is a rare disease characterized by an elevated whole body mast cell number. Anaphylaxis is a severe, generalized hypersensitivity reaction with rapid onset. The problem of anaphylaxis and mastocytosis is due to strongly increased mediator release from the elevated mast cell number durin...