Preemptive analgesia by intravenous low-dose ketamine and epidural morphine in gastrectomy : a randomized double-blind study

• Published in: Anesthesiology Vol. 92; no. 6; pp. 1624 - 1630
• Main Authors: Aida, Sumihisa, Yamakura, Tomohiro, Baba, Hiroshi, Taga, Kiichiro, Fukuda, Satoru, Shimoji, Koki
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Ovid Technologies (Wolters Kluwer Health) 01.06.2000; Lippincott
• Subjects: Aged; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - therapeutic use; Biological and medical sciences; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Antagonists - administration & dosage; Excitatory Amino Acid Antagonists - therapeutic use; Female; Gastrectomy; Humans; Injections, Intravenous; Ketamine; Ketamine - administration & dosage; Ketamine - therapeutic use; Male; Medical sciences; Middle Aged; Morphine; Morphine - administration & dosage; Morphine - therapeutic use; Neuropharmacology; Pain Measurement; Pain, Postoperative; Pain, Postoperative - prevention & control; Pharmacology. Drug treatments; Human; Postoperative; Drug combination; Intravenous administration; Low dose; Morphine; Opiates; Glutamate receptor; Narcotic analgesic; Gastrectomy; Prevention; Analgesia; Chemotherapy; Analgesic; Pain; Ketamine; Surgery; Extradural administration; Digestive diseases; Antagonist; NMDA receptor; Gastric disease

Morphine and ketamine may prevent central sensitization during surgery and result in preemptive analgesia. The reliability of preemptive analgesia, however, is controversial. Gastrectomy patients were given preemptive analgesia consisting of epidural morphine, intravenous low-dose ketamine, and comb...