Reduction of dADAR activity affects the sensitivity of Drosophila melanogaster to spinosad and imidacloprid

• Published in: Pesticide biochemistry and physiology Vol. 104; no. 2; pp. 163 - 169
• Main Authors: Rinkevich, Frank D., Scott, Jeffrey G.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier Inc 01.10.2012; Elsevier
• Subjects: acetylcholine; adenine deaminase; Adenine deaminase acting on RNA; Biological and medical sciences; Drosophila melanogaster; genes; imidacloprid; muscles; mutation; Neonicotinoids; neurons; physiology; RNA; RNA editing; RNAi; spinosad; Spinosyns; toxicity; Neonicotinoids; Spinosyns; RNAi; Adenine deaminase acting on RNA; Nitro compound; RNA interference; RNA; Insecta; Systemic; Organic nitrogen compounds; Neonicotinoid; Reduction; Biopesticide; Nucleic acid; Organic compounds; Biochemical compound; Pesticides; Guanidines; Chemical base; Macrolide; Drosophilidae; Gene silencing; Antibiotic; Organic base; Sensitivity; Arthropoda; Imidacloprid; Invertebrata; Drosophila melanogaster; Diptera; Microbial insecticide

[Display omitted] ► Silencing of dADAR resulted in decreases in A-to-I RNA editing. ► Ubiquitous reduction in RNA editing increased spinosad sensitivity up to 5.9-fold. ► Tissue specific reduction of RNA editing decreased spinosad sensitivity. ► Tissue specific reduction of RNA editing decreased imi...