Impact of neurally mediated antidiuretic effect relative to pressure diuresis during acute changes in sympathetic nerve activity

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 324; no. 1; pp. R82 - R89
• Main Authors: Kawada, Toru, Yokoi, Aimi, Nishiura, Akitsugu, Kakuuchi, Midori, Li, Meihua, Uemura, Kazunori, Suehara, Satoru, Sawada, Satoshi, Saku, Keita
• Format: Journal Article
• Language: English
• Published: United States 01.01.2023
• Subjects: Animals; Antidiuretic Agents - pharmacology; Arterial Pressure; Baroreflex - physiology; Blood Pressure - physiology; Diuresis; Rats; Rats, Inbred WKY; Sympathetic Nervous System - physiology; sympathetic nerve activity; pressure diuresis; arterial pressure; antidiuretic effect

We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressu...