Impact of neurally mediated antidiuretic effect relative to pressure diuresis during acute changes in sympathetic nerve activity
We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressu...
Saved in:
Published in | American journal of physiology. Regulatory, integrative and comparative physiology Vol. 324; no. 1; pp. R82 - R89 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.01.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressure diuresis. We hypothesized that preventing AP changes under PASA would enable the direct estimation of the neurally mediated antidiuretic effect alone. We changed the isolated carotid sinus pressure stepwise from 60 to 180 mmHg and compared the relationship of normalized urine flow (nUF, urine flow normalized by body weight) versus SNA between conditions allowing and preventing baroreflex-mediated changes in the mean AP. The slope of the SNA-nUF relationship was [Formula: see text]nUF
= 0.444 ± 0.074 μL·min
·kg
·%
when the mean AP was variable, whereas it was [Formula: see text]nUF
= -0.143 ± 0.032 μL·min
·kg
·%
when the mean AP was fixed at 100 mmHg (
= 7 rats). The slope associated with the effect of pressure diuresis alone, calculated as [Formula: see text]nUF
- [Formula: see text]nUF
, was 0.586 ± 0.105 μL·min
·kg
·%
. Hence, the potency of the neurally mediated antidiuretic effect |[Formula: see text]nUF
|/([Formula: see text]nUF
- [Formula: see text]nUF
) was 0.235 ± 0.014 relative to the effect of pressure diuresis under PASA. Our findings would aid an integrative understanding of the effects of renal hemodynamic and sympathetic modulations on urine output function. |
---|---|
AbstractList | We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressure diuresis. We hypothesized that preventing AP changes under PASA would enable the direct estimation of the neurally mediated antidiuretic effect alone. We changed the isolated carotid sinus pressure stepwise from 60 to 180 mmHg and compared the relationship of normalized urine flow (nUF, urine flow normalized by body weight) versus SNA between conditions allowing and preventing baroreflex-mediated changes in the mean AP. The slope of the SNA-nUF relationship was [Formula: see text]nUF
var
= 0.444 ± 0.074 μL·min
−1
·kg
−1
·%
−1
when the mean AP was variable, whereas it was [Formula: see text]nUF
fix
= −0.143 ± 0.032 μL·min
−1
·kg
−1
·%
−1
when the mean AP was fixed at 100 mmHg ( n = 7 rats). The slope associated with the effect of pressure diuresis alone, calculated as [Formula: see text]nUF
var
− [Formula: see text]nUF
fix
, was 0.586 ± 0.105 μL·min
−1
·kg
−1
·%
−1
. Hence, the potency of the neurally mediated antidiuretic effect |[Formula: see text]nUF
fix
|/([Formula: see text]nUF
var
− [Formula: see text]nUF
fix
) was 0.235 ± 0.014 relative to the effect of pressure diuresis under PASA. Our findings would aid an integrative understanding of the effects of renal hemodynamic and sympathetic modulations on urine output function. We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with sympathetic nerve activity (SNA) during PASA, urine excretion reflects a neurally mediated antidiuretic effect combined with an effect of pressure diuresis. We hypothesized that preventing AP changes under PASA would enable the direct estimation of the neurally mediated antidiuretic effect alone. We changed the isolated carotid sinus pressure stepwise from 60 to 180 mmHg and compared the relationship of normalized urine flow (nUF, urine flow normalized by body weight) versus SNA between conditions allowing and preventing baroreflex-mediated changes in the mean AP. The slope of the SNA-nUF relationship was [Formula: see text]nUF = 0.444 ± 0.074 μL·min ·kg ·% when the mean AP was variable, whereas it was [Formula: see text]nUF = -0.143 ± 0.032 μL·min ·kg ·% when the mean AP was fixed at 100 mmHg ( = 7 rats). The slope associated with the effect of pressure diuresis alone, calculated as [Formula: see text]nUF - [Formula: see text]nUF , was 0.586 ± 0.105 μL·min ·kg ·% . Hence, the potency of the neurally mediated antidiuretic effect |[Formula: see text]nUF |/([Formula: see text]nUF - [Formula: see text]nUF ) was 0.235 ± 0.014 relative to the effect of pressure diuresis under PASA. Our findings would aid an integrative understanding of the effects of renal hemodynamic and sympathetic modulations on urine output function. |
Author | Kakuuchi, Midori Kawada, Toru Suehara, Satoru Yokoi, Aimi Nishiura, Akitsugu Li, Meihua Sawada, Satoshi Saku, Keita Uemura, Kazunori |
Author_xml | – sequence: 1 givenname: Toru orcidid: 0000-0002-4429-1802 surname: Kawada fullname: Kawada, Toru organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 2 givenname: Aimi orcidid: 0000-0002-3124-912X surname: Yokoi fullname: Yokoi, Aimi organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 3 givenname: Akitsugu surname: Nishiura fullname: Nishiura, Akitsugu organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 4 givenname: Midori surname: Kakuuchi fullname: Kakuuchi, Midori organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 5 givenname: Meihua orcidid: 0000-0003-1184-5482 surname: Li fullname: Li, Meihua organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 6 givenname: Kazunori orcidid: 0000-0003-2900-4702 surname: Uemura fullname: Uemura, Kazunori organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan – sequence: 7 givenname: Satoru surname: Suehara fullname: Suehara, Satoru organization: Innovation Center, Terumo Corporation, Kanagawa, Japan – sequence: 8 givenname: Satoshi surname: Sawada fullname: Sawada, Satoshi organization: Innovation Center, Terumo Corporation, Kanagawa, Japan – sequence: 9 givenname: Keita surname: Saku fullname: Saku, Keita organization: Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Suita, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36409023$$D View this record in MEDLINE/PubMed |
BookMark | eNo9kLtOAzEQRS0EgiTwAxTIJc0GP3aduESIR6RINFCvJvZsYrTxBtsbKR2fjvOAaoo5917pDMm57zwScsvZmPNKPMDXJuCyHzMmWDUWTIgzMsgPUfBSs3MyYFLJQnGur8gwxi_GWClLeUmupCqZZkIOyM9svQGTaNdQj32Att3RNVoHCS0Fn5x1fcDkDMWmwQwGbCG5LdLU0TwfY37TAxRdpLYPzi8pmD4hNSvwS4zUeRp3eSatDkUeQ47nUbd1aXdNLhpoI96c7oh8vjx_PL0V8_fX2dPjvDBS6VTIxqqJtUqBMhrkgjeVFNoAIqiK8Qa0kCCmgKJiwLQwVljE6WJSTY2pKitH5P7Yuwndd48x1WsXDbYteOz6WIuJnJY6a5lkVBxRE7oYAzb1Jrg1hF3NWb03X5_M1wfz9d58Dt2d-vtFFvgf-VMtfwFehYam |
CitedBy_id | crossref_primary_10_1152_ajpregu_00229_2023 crossref_primary_10_1186_s12576_023_00877_1 crossref_primary_10_1186_s12576_023_00861_9 |
Cites_doi | 10.1253/jcj.51.1310 10.1152/ajpheart.1986.251.1.H19 10.1186/s12576-020-00759-w 10.1152/ajpregu.1998.275.4.R1239 10.1007/s12576-010-0096-9 10.1161/CIRCHEARTFAILURE.119.006731 10.1159/000169528 10.1016/j.autneu.2014.10.016 10.1152/ajpheart.1991.260.1.H300 10.1152/ajprenal.1993.265.5.F717 10.1016/B978-012589762-4/50041-4 10.1152/ajprenal.1987.252.5.F856 10.1007/s00380-022-02110-2 10.1007/s12576-015-0412-5 10.1152/ajprenal.1982.242.2.F140 10.1152/ajprenal.1986.250.3.F559 10.1038/s41598-018-35162-4 10.14814/phy2.13887 10.1152/ajpheart.1999.276.1.H326 10.1186/s12576-021-00798-x 10.1172/JCI107079 |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1152/ajpregu.00205.2022 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | CrossRef MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1522-1490 |
EndPage | R89 |
ExternalDocumentID | 10_1152_ajpregu_00205_2022 36409023 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | 23M 2WC 39C 4.4 5GY 5VS 6J9 AAFWJ ACIWK ACPRK ADBBV AFRAH ALMA_UNASSIGNED_HOLDINGS BAWUL BKOMP BTFSW CGR CUY CVF DIK EBS ECM EIF EMOBN F5P H13 ITBOX KQ8 NPM OK1 P2P PQQKQ RAP RHF RHI RPL RPRKH TR2 UKR W8F WH7 WOQ XSW YSK ~02 AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c369t-3fd67dd66a6c9a3b1f5329caeea6501fa923a28ae250a092cd2dee8b758cc55d3 |
ISSN | 0363-6119 |
IngestDate | Fri Jun 28 05:45:41 EDT 2024 Fri Aug 23 21:11:39 EDT 2024 Sat Sep 28 08:22:26 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | sympathetic nerve activity pressure diuresis arterial pressure antidiuretic effect |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c369t-3fd67dd66a6c9a3b1f5329caeea6501fa923a28ae250a092cd2dee8b758cc55d3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-1184-5482 0000-0003-2900-4702 0000-0002-4429-1802 0000-0002-3124-912X |
PMID | 36409023 |
PQID | 2738494097 |
PQPubID | 23479 |
ParticipantIDs | proquest_miscellaneous_2738494097 crossref_primary_10_1152_ajpregu_00205_2022 pubmed_primary_36409023 |
PublicationCentury | 2000 |
PublicationDate | 2023-01-01 20230101 |
PublicationDateYYYYMMDD | 2023-01-01 |
PublicationDate_xml | – month: 01 year: 2023 text: 2023-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | American journal of physiology. Regulatory, integrative and comparative physiology |
PublicationTitleAlternate | Am J Physiol Regul Integr Comp Physiol |
PublicationYear | 2023 |
References | B20 B10 B21 B22 B12 B13 B14 B15 B16 B17 B18 Glantz SA (B11) 2012 B19 B1 B2 B3 B4 B5 B6 B7 B8 B9 |
References_xml | – ident: B17 doi: 10.1253/jcj.51.1310 – ident: B18 doi: 10.1152/ajpheart.1986.251.1.H19 – ident: B2 doi: 10.1186/s12576-020-00759-w – ident: B14 doi: 10.1152/ajpregu.1998.275.4.R1239 – ident: B15 doi: 10.1007/s12576-010-0096-9 – ident: B21 doi: 10.1161/CIRCHEARTFAILURE.119.006731 – ident: B7 doi: 10.1159/000169528 – ident: B13 doi: 10.1016/j.autneu.2014.10.016 – ident: B5 doi: 10.1152/ajpheart.1991.260.1.H300 – ident: B12 doi: 10.1152/ajprenal.1993.265.5.F717 – ident: B1 doi: 10.1016/B978-012589762-4/50041-4 – ident: B3 doi: 10.1152/ajprenal.1987.252.5.F856 – ident: B10 doi: 10.1007/s00380-022-02110-2 – ident: B8 doi: 10.1007/s12576-015-0412-5 – ident: B19 doi: 10.1152/ajprenal.1982.242.2.F140 – ident: B4 doi: 10.1152/ajprenal.1986.250.3.F559 – ident: B16 doi: 10.1038/s41598-018-35162-4 – ident: B22 doi: 10.14814/phy2.13887 – ident: B6 doi: 10.1152/ajpheart.1999.276.1.H326 – volume-title: Primer of Biostatistics year: 2012 ident: B11 contributor: fullname: Glantz SA – ident: B9 doi: 10.1186/s12576-021-00798-x – ident: B20 doi: 10.1172/JCI107079 |
SSID | ssj0004343 |
Score | 2.4652233 |
Snippet | We examined urine excretion during primary acute sympathetic activation (PASA) in anesthetized Wistar-Kyoto rats. Since arterial pressure (AP) changes with... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | R82 |
SubjectTerms | Animals Antidiuretic Agents - pharmacology Arterial Pressure Baroreflex - physiology Blood Pressure - physiology Diuresis Rats Rats, Inbred WKY Sympathetic Nervous System - physiology |
Title | Impact of neurally mediated antidiuretic effect relative to pressure diuresis during acute changes in sympathetic nerve activity |
URI | https://www.ncbi.nlm.nih.gov/pubmed/36409023 https://search.proquest.com/docview/2738494097 |
Volume | 324 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fb9MwELbKeOEFAeNHGSAjIV5QSmbHSfNYIdAAgWDqpL1Fju2M0DWZ2gRUnvif-Qe4s-M0Y0xivERVlF6T3Nfz3fm-O0KepSGTTMowCBMmgyjVKpBmmge5SaM0N1qoGAnOHz7GB0fRu2NxPBr9GlQttU0-UT_-yiv5H63COdArsmSvoNleKJyAz6BfOIKG4fhPOn7bUxyxLaU8Pd04Jgh6kfDGSl22lqTYVW10xJVvdlqGLYDF3QN7EbYl8YxFhaUDjhBsi2XXmyXOLbaCKiyQtA04cObE0LPtt34GvShs2sTm7SegRzv0vnbb9r5LBd5Mx6zrm5Bvv9WvBvK71NbLnderdmuoFrWtRZiVy3Kwv_IFHshlixdls25P2q2YRYuzXxxdQNercpjzYHyQ8_BcLw5Bb2dsTWe6IayGeC8c2nbuCNrnQOws9aGbedQt-odujtHF9URgf1r5FXRy0mLyLRQTuCG2XT19xcAfi2pf6miDLMGyTkZmZWQo4xq5zpJUYMbg_edBi3vuSj39I3qml2AvL97HeW_qkhDJukrzW-RmF-PQmQPsbTIy1R2yO6tA-8sNfU4_9QreJT8dhmldUI9h6jFMhximDsPUY5g2NfUYph7D1GGYWgzTDsO0rOgAw9RimHoM3yVHb17PXx0E3VSQQPE4bQJe6DjROo5lrFLJ8_1CcJYqaYyEaGO_kBCySDaVBpx7GaZMaaYNmB8IjJUSQvN7ZKeqK_OA0CJBIriQiY7ASYsTjCAioURswnQaFdGYvPBvNztzzV-yy_U5Jk-9AjKw0bjxJitTt-sM6W9Rip3lxuS-00wvj8cRlkbzh1f6rT1yY_u_eER2mlVrHoN33ORPLJp-AxSyxpk |
link.rule.ids | 315,786,790,27957,27958 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Impact+of+neurally+mediated+antidiuretic+effect+relative+to+pressure+diuresis+during+acute+changes+in+sympathetic+nerve+activity&rft.jtitle=American+journal+of+physiology.+Regulatory%2C+integrative+and+comparative+physiology&rft.au=Kawada%2C+Toru&rft.au=Yokoi%2C+Aimi&rft.au=Nishiura%2C+Akitsugu&rft.au=Kakuuchi%2C+Midori&rft.date=2023-01-01&rft.issn=0363-6119&rft.eissn=1522-1490&rft.volume=324&rft.issue=1&rft.spage=R82&rft.epage=R89&rft_id=info:doi/10.1152%2Fajpregu.00205.2022&rft.externalDBID=n%2Fa&rft.externalDocID=10_1152_ajpregu_00205_2022 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0363-6119&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0363-6119&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0363-6119&client=summon |