Feasibility of bone assessment by using the nonlinear parameter in trabecular bone

• Published in: Journal of the Korean Physical Society Vol. 62; no. 8; pp. 1108 - 1113
• Main Author: Lee, Kang Il
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Physical Society 01.04.2013; 한국물리학회
• Subjects: Mathematical and Computational Physics; Particle and Nuclear Physics; Physics; Physics and Astronomy; Theoretical; 물리학; Osteoporosis; Nonlinear parameter B/A; Speed of sound; Quantitative ultrasound; Trabecular bone; Bone density; Normalized broadband ultrasound attenuation
• ISSN: 0374-4884; 1976-8524
• DOI: 10.3938/jkps.62.1108

The purpose of the present study is to investigate the feasibility of assessing bone status and osteoporosis by using the nonlinear parameter B/A in bovine trabecular bone in vitro . The B/A values measured in 18 bovine femoral trabecular bone samples by using a finite-amplitude through-transmission method ranged from 63.3 to 122.6. The apparent bone density was highly correlated with the B/A and with the existing quantitative ultrasound parameters of the speed of sound (SOS) and the normalized broadband ultrasound attenuation (nBUA), with Pearson’s correlation coefficients of r = 0.83 to 0.96. The best univariate predictor of the apparent bone density was the B/A, with an adjusted squared correlation coefficient of r 2 = 0.91. These results suggest that the B/A, in addition to the SOS and the nBUA, may have potential as an index for the assessment of bone status and osteoporosis.