Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells
The anti-melanogenic effects of the extract of (AT) root and the extract of AT root fermented by (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT...
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Published in | Journal of microbiology and biotechnology Vol. 28; no. 7; pp. 1061 - 1067 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
한국미생물·생명공학회
28.07.2018
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Abstract | The anti-melanogenic effects of the extract of
(AT) root and the extract of AT root fermented by
(FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 μg/ml, and this inhibitory effect was significantly enhanced by the fermentation process with
. HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract. |
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AbstractList | The anti-melanogenic effects of the extract of Angelica tenuissima (AT) root and the extract of AT root fermented by Aspergillus oryzae (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 μg/ml, and this inhibitory effect was significantly enhanced by the fermentation process with A. oryzae. HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract KCI Citation Count: 1 The anti-melanogenic effects of the extract of (AT) root and the extract of AT root fermented by (FAT) were investigated. These effects were determined by measuring the inhibitory activity of AT and FAT on melanin production in B16F10 melanocytes and with in vitro tyrosinase activity assays. The AT extract inhibited melanin production at concentrations above 250 μg/ml, and this inhibitory effect was significantly enhanced by the fermentation process with . HPLC analysis resulted in the isolation of two active compounds from both the AT and FAT extracts. Their chemical structures were identified as decursin and Z-ligustilide through comparison with previously reported NMR data. The decursin and Z-ligustilide contents were increased in the FAT extract and could be responsible for its enhanced inhibitory effects on melanin production and tyrosinase activity compared with that of the AT extract. |
Author | Namkoong, Seung Park, Yuna Kim, Dayoung Lim, Hyosun Nam, Sang Jip Lee, Sung Ryul Koo, Hyun Jung Yang, Inho Choi, Bomee Lee, Jin Woo Kim, Youn Kyu Sohn, Eun-Hwa Park, Myung Rye |
Author_xml | – sequence: 1 givenname: Yuna surname: Park fullname: Park, Yuna organization: College of Health Science, Kangwon National University, Samcheok 25949, Republic of Korea – sequence: 2 givenname: Dayoung surname: Kim fullname: Kim, Dayoung organization: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Republic of Korea – sequence: 3 givenname: Inho surname: Yang fullname: Yang, Inho organization: Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Republic of Korea – sequence: 4 givenname: Bomee surname: Choi fullname: Choi, Bomee organization: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Republic of Korea – sequence: 5 givenname: Jin Woo surname: Lee fullname: Lee, Jin Woo organization: College of Health Science, Kangwon National University, Samcheok 25949, Republic of Korea – sequence: 6 givenname: Seung surname: Namkoong fullname: Namkoong, Seung organization: College of Health Science, Kangwon National University, Samcheok 25949, Republic of Korea – sequence: 7 givenname: Hyun Jung surname: Koo fullname: Koo, Hyun Jung organization: Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Jeonju 54874, Republic of Korea – sequence: 8 givenname: Sung Ryul surname: Lee fullname: Lee, Sung Ryul organization: Department of Convergence Biomedical Science, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Busan 47392, Republic of Korea – sequence: 9 givenname: Myung Rye surname: Park fullname: Park, Myung Rye organization: Korea Research Institute Bio Science Co., Ltd., Yeoju 12668, Republic of Korea – sequence: 10 givenname: Hyosun surname: Lim fullname: Lim, Hyosun organization: Korea Research Institute Bio Science Co., Ltd., Yeoju 12668, Republic of Korea – sequence: 11 givenname: Youn Kyu surname: Kim fullname: Kim, Youn Kyu organization: Korea Research Institute Bio Science Co., Ltd., Yeoju 12668, Republic of Korea – sequence: 12 givenname: Sang Jip surname: Nam fullname: Nam, Sang Jip organization: Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Republic of Korea – sequence: 13 givenname: Eun-Hwa surname: Sohn fullname: Sohn, Eun-Hwa organization: College of Health Science, Kangwon National University, Samcheok 25949, Republic of Korea |
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Keywords | Z-ligustilide decursin fermentation Aspergillus oryzae Angelica tenuissimae anti-melanogenic activity |
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Snippet | The anti-melanogenic effects of the extract of
(AT) root and the extract of AT root fermented by
(FAT) were investigated. These effects were determined by... The anti-melanogenic effects of the extract of Angelica tenuissima (AT) root and the extract of AT root fermented by Aspergillus oryzae (FAT) were... |
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Title | Decursin and Z-Ligustilide in Angelica tenuissima Root Extract Fermented by Aspergillus oryzae Display Anti-Pigment Activity in Melanoma Cells |
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