The effects of an acute load of thyroxine on the transport and peripheral metabolism of triiodothyronine in man

• Published in: The Journal of clinical investigation Vol. 49; no. 4; pp. 650 - 654
• Main Authors: Woeber, Kenneth A., Hecker, Exequiel, Ingbar, Sidney H.
• Format: Journal Article
• Language: English
• Published: United States 01.04.1970
• Subjects: Adult; Binding Sites - drug effects; Electrophoresis; Humans; Iodine Isotopes; Kinetics; Male; Middle Aged; Postural Balance; Protein Binding - drug effects; Thyroxine - pharmacology; Thyroxine-Binding Proteins - metabolism; Triiodothyronine - blood; Triiodothyronine - metabolism; Triiodothyronine - urine
• ISSN: 0021-9738
• DOI: 10.1172/JCI106276

In order to examine the question of whether thyroxine-binding globulin (TBG) influences significantly the peripheral metabolism of 3,3',5-triiodo-L-thyronine (T(3)) in vivo, paired studies of the effects of a large intravenous load of L-thyroxine (T(4)) on the kinetics of (131)I-labeled T(3) me...