Roller compaction/Dry granulation: Use of the thin layer model for predicting densities and forces during roller compaction
The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process, provided that it was established with sufficient accuracy in the tableting experiments. In particular, the process of compaction between the rolls is p...
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Published in | Powder technology Vol. 199; no. 2; pp. 165 - 175 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
23.04.2010
Elsevier |
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Abstract | The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process, provided that it was established with sufficient accuracy in the tableting experiments. In particular, the process of compaction between the rolls is presumed to consist of three parts, a rearrangement, an “exponential” and an elastic recovery phase. The rearrangement and “exponential” phases are used to calculate the densification of the material. The forces between the rolls during elastic recovery, the third phase, proved to be essential to the prediction, because 20% to 30% of the total roller compaction force is required to counteract ribbon recovery. Four different excipients and one powder blend were tested in the model. For two materials, the density and force predictions turned out to be accurate within ±
2.5% and ±
10%, respectively. For one excipient and the model blend, the predictions deviated systematically whereas those for the remaining excipient were within the above mentioned limits in ca. 50% of the experiments. For explaining these differences, we evaluated both the influence of the course of the force–time profile, at comparable densification times, and the influence of different compression times, for comparable force–time profiles. Finally, the impact of density distributions within ribbons on the prediction was estimated.
The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process. The validity of this simple model will be investigated with respect to predicting ribbon densities as a function of roll compaction forces (and vice versa) for different excipients and for a model powder blend.
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AbstractList | The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process, provided that it was established with sufficient accuracy in the tableting experiments. In particular, the process of compaction between the rolls is presumed to consist of three parts, a rearrangement, an "exponential" and an elastic recovery phase. The rearrangement and "exponential" phases are used to calculate the densification of the material. The forces between the rolls during elastic recovery, the third phase, proved to be essential to the prediction, because 20% to 30% of the total roller compaction force is required to counteract ribbon recovery. Four different excipients and one powder blend were tested in the model. For two materials, the density and force predictions turned out to be accurate within Ac2.5% and Ac10%, respectively. For one excipient and the model blend, the predictions deviated systematically whereas those for the remaining excipient were within the above mentioned limits in ca. 50% of the experiments. For explaining these differences, we evaluated both the influence of the course of the force-time profile, at comparable densification times, and the influence of different compression times, for comparable force-time profiles. Finally, the impact of density distributions within ribbons on the prediction was estimated. The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process. The validity of this simple model will be investigated with respect to predicting ribbon densities as a function of roll compaction forces (and vice versa) for different excipients and for a model powder blend. Display Omitted The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process, provided that it was established with sufficient accuracy in the tableting experiments. In particular, the process of compaction between the rolls is presumed to consist of three parts, a rearrangement, an “exponential” and an elastic recovery phase. The rearrangement and “exponential” phases are used to calculate the densification of the material. The forces between the rolls during elastic recovery, the third phase, proved to be essential to the prediction, because 20% to 30% of the total roller compaction force is required to counteract ribbon recovery. Four different excipients and one powder blend were tested in the model. For two materials, the density and force predictions turned out to be accurate within ± 2.5% and ± 10%, respectively. For one excipient and the model blend, the predictions deviated systematically whereas those for the remaining excipient were within the above mentioned limits in ca. 50% of the experiments. For explaining these differences, we evaluated both the influence of the course of the force–time profile, at comparable densification times, and the influence of different compression times, for comparable force–time profiles. Finally, the impact of density distributions within ribbons on the prediction was estimated. The thin layer model is based on the assumption that the deformation of powder during tableting can be transferred to the roller compaction process. The validity of this simple model will be investigated with respect to predicting ribbon densities as a function of roll compaction forces (and vice versa) for different excipients and for a model powder blend. [Display omitted] |
Author | Lammens, Robert F. Steffens, Klaus-Jürgen Peter, Stefanie |
Author_xml | – sequence: 1 givenname: Stefanie surname: Peter fullname: Peter, Stefanie email: stefanie.peter@uni-bonn.de organization: Department of Pharmaceutical Technology, Rheinische-Friedrich-Wilhelms-University of Bonn, Germany – sequence: 2 givenname: Robert F. surname: Lammens fullname: Lammens, Robert F. email: rob.lammens@web.de organization: Technical Services Consult Lammens, Heymannstr. 50, D-51373 Leverkusen, Germany – sequence: 3 givenname: Klaus-Jürgen surname: Steffens fullname: Steffens, Klaus-Jürgen organization: Department of Pharmaceutical Technology, Rheinische-Friedrich-Wilhelms-University of Bonn, Germany |
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Cites_doi | 10.1023/A:1016364613722 10.1115/1.3627325 10.1016/j.ejps.2004.04.001 10.1111/j.2042-7158.1979.tb13556.x 10.1016/j.ces.2005.02.022 10.1111/j.2042-7158.1978.tb13340.x 10.1016/j.powtec.2007.02.011 10.1016/j.ijpharm.2003.09.034 10.1016/S0032-5910(02)00203-6 10.3109/03639047709055633 10.1016/S0939-6411(98)00093-9 10.1016/S0378-5173(94)04837-1 10.1023/A:1018944724083 10.4164/sptj.38.150 10.1016/S0928-0987(03)00133-7 10.1016/0032-5910(86)80100-0 |
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Keywords | Roller compaction Ribbon density Compression speed Force-displacement measurements Elastic recovery Prediction model Compression Densification Deformation Granulation Prediction Compaction Density distribution Forecast model Density Modeling Powder |
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References | S. Erling, Trockengranulation: Entwicklung einer Basisrezeptur für die Walzenkompaktierung mit Hilfe von Exzenterpresse, Mikropaktor und Produktionskompaktor, Diploma thesis, University of Bonn, Germany (2001). Mansa, Bridson, Greenwood, Barker, Seville (bib10) 2008; 181 Inghelbrecht, Remon (bib11) 1997; 148 Dec, Zavaliangos, Cunningham (bib13) 2003; 130 de Blaey, Polderman (bib25) 1970; 105 R.F. Lammens, C.Pörtner, Control of Production Quality During Dry Granulation with Roller Compactors, Proceedings of 3rd World Meeting APV/APGI, 3rd to 6th of April 2000, Berlin, Germany. U. Caspar, Viskoelastische Phänomene bei der Tablettierung, PhD thesis, University of Bonn, Germany (1983). Leuenberger, Rohera (bib28) 1986; 3 F. Bicane, Trockengranulation mit Hilfe des Micropactor, PhD thesis, University of Bonn, Germany (2003). Johanson (bib6) 1965; 32 Shlieout, Lammens, Kleinebudde (bib1) 2000; 12 Heckel (bib22) 1961; 221 Funakoshi, Asogawa, Satake (bib31) 1977; 3 Freitag, Kleinebudde (bib4) 2004; 22 Heckel (bib23) 1961; 221 Duberg, Nyström (bib24) 1986; 46 Belda, Mielck (bib18) 1999; 47 Rees, Rue (bib29) 1978; 30 Katashinskii (bib9) 1986; 10 S. Körschgen, Porositätsberechnung der Schülpe während der Kompaktierung mit einer 3-W-Polygran Walzenpresse und Qualifizierung/Kalibrierung dieses Kompaktors, Diploma thesis, University of Applied Sciences of Düsseldorf, Germany (1996). J. Cunningham, Experimental Studies and Modeling of the Roller Compaction of Pharmaceutical Powders, PhD thesis, Drexel University, Philadelphia, PA, USA (2005). H. Busies, Dichteverteilungen in Schülpen, PhD thesis, University of Bonn, Germany (2004). Holman, Marshall (bib17) 1993; 6 Michel, B., Contribution à l'étude de l'agglomération des poudres en press à rouleaux lisses, Thèse de doctorat (PhD thesis), Université de Technologie de Compiègne, France, (1994). Odagi, Tanaka, Tsuji (bib12) 2001; 38 Bindhumadhavan, Seville, Adams, Greenwood, Fitzpatrick (bib7) 2005; 60 R.F. Lammens, The evaluation of force-displacement measurements during one-sided powder compaction in cylindrical dies, PhD thesis, University of Leiden, Netherlands (1980). Freitag, Kleinebudde (bib3) 2003; 19 Ho, Barker, Spence, Jones (bib16) 1979; 31 Zinchuk, Mullarney, Hancock (bib2) 2004; 269 Bindhumadhavan Gururajan, Roll Compaction of pharmaceutical powders, PhD thesis, University of Birmingham, United Kingdom (2004). Shlieout (10.1016/j.powtec.2010.01.002_bib1) 2000; 12 Freitag (10.1016/j.powtec.2010.01.002_bib4) 2004; 22 Heckel (10.1016/j.powtec.2010.01.002_bib22) 1961; 221 Inghelbrecht (10.1016/j.powtec.2010.01.002_bib11) 1997; 148 Rees (10.1016/j.powtec.2010.01.002_bib29) 1978; 30 10.1016/j.powtec.2010.01.002_bib21 10.1016/j.powtec.2010.01.002_bib20 10.1016/j.powtec.2010.01.002_bib15 10.1016/j.powtec.2010.01.002_bib14 10.1016/j.powtec.2010.01.002_bib19 Ho (10.1016/j.powtec.2010.01.002_bib16) 1979; 31 Katashinskii (10.1016/j.powtec.2010.01.002_bib9) 1986; 10 Heckel (10.1016/j.powtec.2010.01.002_bib23) 1961; 221 10.1016/j.powtec.2010.01.002_bib5 Zinchuk (10.1016/j.powtec.2010.01.002_bib2) 2004; 269 10.1016/j.powtec.2010.01.002_bib30 Johanson (10.1016/j.powtec.2010.01.002_bib6) 1965; 32 10.1016/j.powtec.2010.01.002_bib8 Mansa (10.1016/j.powtec.2010.01.002_bib10) 2008; 181 Holman (10.1016/j.powtec.2010.01.002_bib17) 1993; 6 Leuenberger (10.1016/j.powtec.2010.01.002_bib28) 1986; 3 Bindhumadhavan (10.1016/j.powtec.2010.01.002_bib7) 2005; 60 Belda (10.1016/j.powtec.2010.01.002_bib18) 1999; 47 10.1016/j.powtec.2010.01.002_bib27 10.1016/j.powtec.2010.01.002_bib26 Duberg (10.1016/j.powtec.2010.01.002_bib24) 1986; 46 Odagi (10.1016/j.powtec.2010.01.002_bib12) 2001; 38 Funakoshi (10.1016/j.powtec.2010.01.002_bib31) 1977; 3 Freitag (10.1016/j.powtec.2010.01.002_bib3) 2003; 19 de Blaey (10.1016/j.powtec.2010.01.002_bib25) 1970; 105 Dec (10.1016/j.powtec.2010.01.002_bib13) 2003; 130 |
References_xml | – volume: 269 start-page: 403 year: 2004 end-page: 415 ident: bib2 article-title: Simulation of roller compaction using a laboratory scale compaction simulator publication-title: Int. J. Pharm. contributor: fullname: Hancock – volume: 22 start-page: 325 year: 2004 end-page: 333 ident: bib4 article-title: How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets publication-title: Eur. J. Pharm. Sci. contributor: fullname: Kleinebudde – volume: 3 start-page: 555 year: 1977 end-page: 573 ident: bib31 article-title: The use of a novel roller compactor with a concavo-convex roller pair to obtain uniform compacting pressure publication-title: Drug Dev. Ind. Pharm. contributor: fullname: Satake – volume: 46 start-page: 67 year: 1986 end-page: 75 ident: bib24 article-title: Studies in direct compression of tablets—XVII. porosity–pressure curves for the characterisation of volume reduction mechanism in powder compression publication-title: Powder Technol. contributor: fullname: Nyström – volume: 19 start-page: 281 year: 2003 end-page: 289 ident: bib3 article-title: How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates publication-title: Eur. J. Pharm. Sci. contributor: fullname: Kleinebudde – volume: 38 start-page: 150 year: 2001 end-page: 159 ident: bib12 article-title: Compressive flow property of powder in roll-type presses—Numerical simulation by discrete element method (in Japanese) publication-title: J. Soc. Powder Technol., Japan contributor: fullname: Tsuji – volume: 3 start-page: 12 year: 1986 end-page: 22 ident: bib28 article-title: Fundamentals of powder compression. I. The compactibility and compressibility of pharmaceutical powders publication-title: Pharm. Res. contributor: fullname: Rohera – volume: 30 start-page: 601 year: 1978 end-page: 607 ident: bib29 article-title: Time-dependent deformation of some direct compression excipients publication-title: J Pharm. Pharmacol. contributor: fullname: Rue – volume: 10 start-page: 765 year: 1986 end-page: 772 ident: bib9 article-title: Analytical determination of specific pressure during the rolling of metal powders (in Russian) publication-title: Sov. Powder Metal Ceram. contributor: fullname: Katashinskii – volume: 47 start-page: 231 year: 1999 end-page: 245 ident: bib18 article-title: The tableting machine as an analytical instrument: qualification of the tableting machine and the instrumentation with respect to the determination of punch separation and validation of the calibration procedures publication-title: Eur. J. Pharm. Biopharm. contributor: fullname: Mielck – volume: 60 start-page: 3891 year: 2005 end-page: 3897 ident: bib7 article-title: Roll compaction of a pharmaceutical excipient: experimental validation of rolling theory for granular solids publication-title: Chem. Eng. Sci. contributor: fullname: Fitzpatrick – volume: 32 start-page: 842 year: 1965 end-page: 848 ident: bib6 article-title: A rolling theory for granular solids publication-title: J. Appl. Mech., Trans. ASME contributor: fullname: Johanson – volume: 105 start-page: 241 year: 1970 end-page: 250 ident: bib25 article-title: Compression of pharmaceuticals I. The quantitative Interpretation of force–displacement curves publication-title: Pharm. Weekblad contributor: fullname: Polderman – volume: 12 start-page: 24 year: 2000 end-page: 35 ident: bib1 article-title: Dry granulation with a roller compactor—part I: the functional units and operation modes publication-title: Pharm. Tech. Europe contributor: fullname: Kleinebudde – volume: 130 start-page: 265 year: 2003 end-page: 271 ident: bib13 article-title: Comparison of various modelling methods for analysis of powder compaction in roller press publication-title: Powder Technol. contributor: fullname: Cunningham – volume: 181 start-page: 217 year: 2008 end-page: 225 ident: bib10 article-title: Using intelligent software to predict the effects of formulation and processing parameters on roller compaction publication-title: Powder Technol. contributor: fullname: Seville – volume: 221 start-page: 671 year: 1961 end-page: 675 ident: bib22 article-title: Pressure–density relationships in powder compaction publication-title: Trans. Metall. Soc. of AIME. contributor: fullname: Heckel – volume: 6 start-page: 816 year: 1993 end-page: 822 ident: bib17 article-title: Calibration of a compaction simulator for the measurement of tablet thickness during compression publication-title: Pharm. Research contributor: fullname: Marshall – volume: 31 start-page: 471 year: 1979 ident: bib16 article-title: A comparison of three methods of mounting a linear variable displacement transducer on an instrumented tablet machine publication-title: J. Pharm. Pharmacol. contributor: fullname: Jones – volume: 221 start-page: 1001 year: 1961 end-page: 1008 ident: bib23 article-title: An analysis of powder compaction phenomena publication-title: Trans. Metall. Soc. of AIME contributor: fullname: Heckel – volume: 148 start-page: 103 year: 1997 end-page: 115 ident: bib11 article-title: Instrumentation of a roll compactor and evaluation of the parameter settings by neural networks publication-title: Int. J. Pharm. contributor: fullname: Remon – volume: 12 start-page: 24 year: 2000 ident: 10.1016/j.powtec.2010.01.002_bib1 article-title: Dry granulation with a roller compactor—part I: the functional units and operation modes publication-title: Pharm. Tech. Europe contributor: fullname: Shlieout – volume: 3 start-page: 12 issue: 1 year: 1986 ident: 10.1016/j.powtec.2010.01.002_bib28 article-title: Fundamentals of powder compression. I. The compactibility and compressibility of pharmaceutical powders publication-title: Pharm. Res. doi: 10.1023/A:1016364613722 contributor: fullname: Leuenberger – volume: 32 start-page: 842 year: 1965 ident: 10.1016/j.powtec.2010.01.002_bib6 article-title: A rolling theory for granular solids publication-title: J. Appl. Mech., Trans. ASME doi: 10.1115/1.3627325 contributor: fullname: Johanson – volume: 22 start-page: 325 year: 2004 ident: 10.1016/j.powtec.2010.01.002_bib4 article-title: How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2004.04.001 contributor: fullname: Freitag – ident: 10.1016/j.powtec.2010.01.002_bib27 – ident: 10.1016/j.powtec.2010.01.002_bib20 – volume: 31 start-page: 471 year: 1979 ident: 10.1016/j.powtec.2010.01.002_bib16 article-title: A comparison of three methods of mounting a linear variable displacement transducer on an instrumented tablet machine publication-title: J. Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1979.tb13556.x contributor: fullname: Ho – volume: 60 start-page: 3891 year: 2005 ident: 10.1016/j.powtec.2010.01.002_bib7 article-title: Roll compaction of a pharmaceutical excipient: experimental validation of rolling theory for granular solids publication-title: Chem. Eng. Sci. doi: 10.1016/j.ces.2005.02.022 contributor: fullname: Bindhumadhavan – volume: 30 start-page: 601 year: 1978 ident: 10.1016/j.powtec.2010.01.002_bib29 article-title: Time-dependent deformation of some direct compression excipients publication-title: J Pharm. Pharmacol. doi: 10.1111/j.2042-7158.1978.tb13340.x contributor: fullname: Rees – volume: 181 start-page: 217 issue: 2 year: 2008 ident: 10.1016/j.powtec.2010.01.002_bib10 article-title: Using intelligent software to predict the effects of formulation and processing parameters on roller compaction publication-title: Powder Technol. doi: 10.1016/j.powtec.2007.02.011 contributor: fullname: Mansa – volume: 269 start-page: 403 year: 2004 ident: 10.1016/j.powtec.2010.01.002_bib2 article-title: Simulation of roller compaction using a laboratory scale compaction simulator publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2003.09.034 contributor: fullname: Zinchuk – volume: 130 start-page: 265 year: 2003 ident: 10.1016/j.powtec.2010.01.002_bib13 article-title: Comparison of various modelling methods for analysis of powder compaction in roller press publication-title: Powder Technol. doi: 10.1016/S0032-5910(02)00203-6 contributor: fullname: Dec – volume: 3 start-page: 555 issue: 6 year: 1977 ident: 10.1016/j.powtec.2010.01.002_bib31 article-title: The use of a novel roller compactor with a concavo-convex roller pair to obtain uniform compacting pressure publication-title: Drug Dev. Ind. Pharm. doi: 10.3109/03639047709055633 contributor: fullname: Funakoshi – ident: 10.1016/j.powtec.2010.01.002_bib8 – volume: 47 start-page: 231 year: 1999 ident: 10.1016/j.powtec.2010.01.002_bib18 article-title: The tableting machine as an analytical instrument: qualification of the tableting machine and the instrumentation with respect to the determination of punch separation and validation of the calibration procedures publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/S0939-6411(98)00093-9 contributor: fullname: Belda – ident: 10.1016/j.powtec.2010.01.002_bib14 – volume: 148 start-page: 103 year: 1997 ident: 10.1016/j.powtec.2010.01.002_bib11 article-title: Instrumentation of a roll compactor and evaluation of the parameter settings by neural networks publication-title: Int. J. Pharm. doi: 10.1016/S0378-5173(94)04837-1 contributor: fullname: Inghelbrecht – volume: 6 start-page: 816 issue: 10 year: 1993 ident: 10.1016/j.powtec.2010.01.002_bib17 article-title: Calibration of a compaction simulator for the measurement of tablet thickness during compression publication-title: Pharm. Research doi: 10.1023/A:1018944724083 contributor: fullname: Holman – volume: 10 start-page: 765 issue: 6 year: 1986 ident: 10.1016/j.powtec.2010.01.002_bib9 article-title: Analytical determination of specific pressure during the rolling of metal powders (in Russian) publication-title: Sov. Powder Metal Ceram. contributor: fullname: Katashinskii – volume: 221 start-page: 1001 year: 1961 ident: 10.1016/j.powtec.2010.01.002_bib23 article-title: An analysis of powder compaction phenomena publication-title: Trans. Metall. Soc. of AIME contributor: fullname: Heckel – volume: 38 start-page: 150 year: 2001 ident: 10.1016/j.powtec.2010.01.002_bib12 article-title: Compressive flow property of powder in roll-type presses—Numerical simulation by discrete element method (in Japanese) publication-title: J. Soc. Powder Technol., Japan doi: 10.4164/sptj.38.150 contributor: fullname: Odagi – volume: 221 start-page: 671 year: 1961 ident: 10.1016/j.powtec.2010.01.002_bib22 article-title: Pressure–density relationships in powder compaction publication-title: Trans. Metall. Soc. of AIME. contributor: fullname: Heckel – ident: 10.1016/j.powtec.2010.01.002_bib26 – ident: 10.1016/j.powtec.2010.01.002_bib21 – ident: 10.1016/j.powtec.2010.01.002_bib5 – volume: 19 start-page: 281 year: 2003 ident: 10.1016/j.powtec.2010.01.002_bib3 article-title: How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates publication-title: Eur. J. Pharm. Sci. doi: 10.1016/S0928-0987(03)00133-7 contributor: fullname: Freitag – ident: 10.1016/j.powtec.2010.01.002_bib19 – volume: 46 start-page: 67 year: 1986 ident: 10.1016/j.powtec.2010.01.002_bib24 article-title: Studies in direct compression of tablets—XVII. porosity–pressure curves for the characterisation of volume reduction mechanism in powder compression publication-title: Powder Technol. doi: 10.1016/0032-5910(86)80100-0 contributor: fullname: Duberg – ident: 10.1016/j.powtec.2010.01.002_bib30 – ident: 10.1016/j.powtec.2010.01.002_bib15 – volume: 105 start-page: 241 year: 1970 ident: 10.1016/j.powtec.2010.01.002_bib25 article-title: Compression of pharmaceuticals I. The quantitative Interpretation of force–displacement curves publication-title: Pharm. Weekblad contributor: fullname: de Blaey |
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SubjectTerms | Applied sciences Blends Chemical engineering Compression speed Density Elastic recovery Exact sciences and technology Excipients Force-displacement measurements Mathematical models Miscellaneous Prediction model Ribbon density Ribbons Roller compaction Rollers Rolls Sintering, pelletization, granulation Solid-solid systems Thin films |
Title | Roller compaction/Dry granulation: Use of the thin layer model for predicting densities and forces during roller compaction |
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