The Genomic Revolution and Endocrine Pathology

The genome has been sequenced. However, the functions of each gene remain to be elucidated through phenotypic analysis. This analysis has been called phenogenomics. That part of phenogenomics related to disease can be called pathogenomics or Genomic Pathology. The initial phases of disease analysis...

Full description

Saved in:
Bibliographic Details
Published inEndocrine pathology Vol. 19; no. 3; pp. 139 - 147
Main Authors Couto, Suzana S., Cardiff, Robert D.
Format Journal Article
LanguageEnglish
Published New York Humana Press Inc 01.09.2008
Springer Nature B.V
Subjects
Animals
Endocrine System Diseases - genetics
Endocrinology
Endocrinology - trends
Genomics - trends
Humans
Medicine
Medicine & Public Health
Oncology
Pathology
SV40
genomics
neuroendocrine
endocrine pathology
genetically engineered mice
Online AccessGet full text

Cover

More Information
Summary:The genome has been sequenced. However, the functions of each gene remain to be elucidated through phenotypic analysis. This analysis has been called phenogenomics. That part of phenogenomics related to disease can be called pathogenomics or Genomic Pathology. The initial phases of disease analysis will use genetically modified mice. The proliferation of ambitious programs designed to use mice for phenogenomics has been met with alarm by comparative pathologists who note the lack of qualified genomic pathologists and of training programs in genomic pathology. While endocrine pathology offers a number of excellent examples of the contributions made by pathologists to the scientific literature, it also contains examples of the hazards of working with untrained, unwary personnel.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1046-3976
1559-0097
DOI:10.1007/s12022-008-9042-2