The Expression of Type I Growth Factor Receptors in the Squamous Neoplastic Changes of Uterine Cervix
Aim.The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor...
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Published in | Gynecologic oncology Vol. 73; no. 1; pp. 62 - 71 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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San Diego, CA
Elsevier Inc
01.04.1999
Elsevier |
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Abstract | Aim.The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix.
Materials.A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined.
Results.Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neugene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma.
Conclusions.The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma. |
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AbstractList | The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix.
A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined.
Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma.
The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma. AIMThe type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix.MATERIALSA total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined.RESULTSOur results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neu gene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma.CONCLUSIONSThe coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma. Aim.The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this study, we systematically investigated the frequency and distribution of these four receptors in relation to neoplastic changes and tumor behaviors in the uterine cervix. Materials.A total 84 of cases including 12 cases of normal cervical tissues, 6 cases of low grade squamous intraepithelial lesion, 10 cases of high grade squamous intraepithelial lesion, and 56 cases of squamous cells carcinoma were examined. Results.Our results show significant difference with increasing grades of dysplasia in terms of these four receptor expressions. No association was found between these four receptors and cell keratinization/differentiation of squamous cell carcinoma of the cervix. Of the four receptors studied, only the expression of erbB2/neugene was significantly associated with lymph nodal metastasis. Moreover, we find that the coexpression of ErbB1 and ErbB4 was significant in cervical carcinoma. Conclusions.The coexpression of ErbB1 and ErbB4 in cervical carcinoma suggests that they may be involved in receptor heterodimerization leading to the activation of signaling pathway in the cervical carcinoma. |
Author | Liu, Dai-Wei Tsao, Yeou-Ping Chang, Junn-Liang Han, Chih-Ping Chen, Show-Li Lee, Wei-Hwa |
Author_xml | – sequence: 1 givenname: Junn-Liang surname: Chang fullname: Chang, Junn-Liang organization: Department of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan, ROC – sequence: 2 givenname: Yeou-Ping surname: Tsao fullname: Tsao, Yeou-Ping organization: Department of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan, ROC – sequence: 3 givenname: Dai-Wei surname: Liu fullname: Liu, Dai-Wei organization: Department of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan, ROC – sequence: 4 givenname: Chih-Ping surname: Han fullname: Han, Chih-Ping organization: Department of Obstetrics & Gynecology, The 803 Army General Hospital, Taichung, Taiwan, ROC – sequence: 5 givenname: Wei-Hwa surname: Lee fullname: Lee, Wei-Hwa organization: Department of Pathology, Tri-Service General Hospital, Taipei, Taiwan, ROC – sequence: 6 givenname: Show-Li surname: Chen fullname: Chen, Show-Li organization: Department of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan, ROC |
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Cites_doi | 10.1074/jbc.271.7.3884 10.1007/BF00666177 10.1016/S0021-9258(17)36676-0 10.1126/science.2305263 10.1038/366473a0 10.1016/0090-8258(91)90355-9 10.1016/0090-8258(91)90107-G 10.1016/0090-8258(89)90540-4 10.1002/cncr.2820690519 10.1016/0092-8674(94)90564-9 10.1136/jcp.46.2.149 10.1136/jcp.45.7.594 10.1016/0140-6736(91)92518-7 10.1146/annurev.bi.62.070193.002321 10.1046/j.1525-1438.1995.05040282.x 10.1111/j.1525-1438.1991.tb00034.x 10.1074/jbc.271.9.4813 10.1172/JCI111770 10.1002/1097-0142(19940201)73:3<668::AID-CNCR2820730327>3.0.CO;2-D |
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Keywords | growth factor receptor cervical carcinoma immunohistochemistry Histological grading Human Immunohistochemistry Premalignant lesion Gene overexpression Malignant tumor Gene expression Female genital diseases Pathology Cervical dysplasia Female Uterine cervix diseases Growth factor Biological receptor |
Language | English |
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Snippet | Aim.The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In... The type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In this... AIMThe type I family of growth factor receptors includes ErbB1, ErbB2, ErbB3, and ErbB4 which are frequently overexpressed in various human cancer cells. In... |
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SubjectTerms | Biological and medical sciences Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology cervical carcinoma Female Female genital diseases Gene Expression Regulation, Neoplastic growth factor receptor Gynecology. Andrology. Obstetrics Humans immunohistochemistry Medical sciences Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - biosynthesis Receptor, Epidermal Growth Factor - analysis Receptor, Epidermal Growth Factor - biosynthesis Receptor, ErbB-2 - analysis Receptor, ErbB-2 - biosynthesis Receptor, ErbB-3 Receptor, ErbB-4 Tumors Uterine Cervical Neoplasms - chemistry Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology |
Title | The Expression of Type I Growth Factor Receptors in the Squamous Neoplastic Changes of Uterine Cervix |
URI | https://dx.doi.org/10.1006/gyno.1998.5301 https://www.ncbi.nlm.nih.gov/pubmed/10094882 https://search.proquest.com/docview/69652462 |
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