Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials

Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of...

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Published inNutrients Vol. 13; no. 9; p. 3001
Main Authors Barkhidarian, Bahareh, Roldos, Lucas, Iskandar, Michèle M., Saedisomeolia, Ahmad, Kubow, Stan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.08.2021
MDPI
Subjects
Bacteria
Bias
Bibliographic data bases
calcium
Clinical trials
Dietary minerals
folic acid
Food
Gastrointestinal Microbiome
Health care
Healthy Volunteers
Humans
Intervention
iron
Malnutrition
Malnutrition - blood
Malnutrition - prevention & control
meta-analysis
Microbiota
Micronutrients - blood
Microorganisms
Minerals - blood
Nutritional Status
Prebiotics
Probiotics
Public health
risk
Systematic Review
Trace Elements - blood
vitamin B12
Vitamins
Vitamins - blood
zinc
United States > US
folate
calcium
vitamin A
vitamin D
vitamin E
iron
micronutrients
B vitamins
zinc
probiotics
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Abstract Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.
AbstractList Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.
Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.
Author Iskandar, Michèle M.
Kubow, Stan
Barkhidarian, Bahareh
Saedisomeolia, Ahmad
Roldos, Lucas
AuthorAffiliation 1 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran 1471613151, Iran; bahar.darian@gmail.com
2 School of Human Nutrition, McGill University, 21111 Lakeshore, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada; lucas.roldos@mail.mcgill.ca (L.R.); michele.iskandar@mail.mcgill.ca (M.M.I.)
AuthorAffiliation_xml – name: 1 Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Keshavarz Blvd., Tehran 1471613151, Iran; bahar.darian@gmail.com
– name: 2 School of Human Nutrition, McGill University, 21111 Lakeshore, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada; lucas.roldos@mail.mcgill.ca (L.R.); michele.iskandar@mail.mcgill.ca (M.M.I.)
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  givenname: Bahareh
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  fullname: Barkhidarian, Bahareh
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  orcidid: 0000-0001-5831-9880
  surname: Kubow
  fullname: Kubow, Stan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34578878$$D View this record in MEDLINE/PubMed
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Keywords folate
calcium
vitamin A
vitamin D
vitamin E
iron
micronutrients
B vitamins
zinc
probiotics
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Snippet Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which...
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SubjectTerms Bacteria
Bias
Bibliographic data bases
calcium
Clinical trials
Dietary minerals
folic acid
Food
Gastrointestinal Microbiome
Health care
Healthy Volunteers
Humans
Intervention
iron
Malnutrition
Malnutrition - blood
Malnutrition - prevention & control
meta-analysis
Microbiota
Micronutrients - blood
Microorganisms
Minerals - blood
Nutritional Status
Prebiotics
Probiotics
Public health
risk
Systematic Review
Trace Elements - blood
vitamin B12
Vitamins
Vitamins - blood
zinc
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Title Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials
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Volume 13
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