Nipple-Sparing Mastectomy: Critical Assessment of 51 Procedures and Implications for Selection Criteria

• Published in: Annals of surgical oncology Vol. 15; no. 12; pp. 3396 - 3401
• Main Authors: Voltura, Anna M., Tsangaris, Theodore N., Rosson, Gedge D., Jacobs, Lisa K., Flores, Jaime I., Singh, Navin K., Argani, Pedram, Balch, Charles M.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.12.2008; Springer Nature B.V
• Subjects: Adult; Aged; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Breast Oncology; Carcinoma, Intraductal, Noninfiltrating - drug therapy; Carcinoma, Intraductal, Noninfiltrating - pathology; Carcinoma, Intraductal, Noninfiltrating - surgery; Female; Humans; Mammaplasty - statistics & numerical data; Mastectomy - methods; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Neoplasm Staging; Nipples - pathology; Nipples - surgery; Oncology; Patient Satisfaction; Patient Selection; Retrospective Studies; Risk Assessment; Surgery; Surgical Oncology; Treatment Outcome; Breast Conservation; Occult Tumor; Nipple; Terminal Duct Lobular Unit; Sentinel Node
• DOI: 10.1245/s10434-008-0102-0
• ISSN: 1068-9265

Background Retrospective studies have shown that occult nipple–areolar complex (NAC) involvement in breast cancer is low, occurring in 6–10% of women undergoing skin-sparing mastectomy (SSM). The cosmetic result and high patient satisfaction of nipple-sparing mastectomy (NSM) has prompted further evaluation of the oncologic safety of this procedure. Methods We conducted a retrospective chart review of 36 self-selected patients who underwent 51 NSM procedures between 2002 and 2007. Criterion for patient selection was no clinical evidence of nipple–areolar tumor involvement. All patients had the base of the NAC evaluated for occult tumor by permanent histologic section assessment. We also evaluated tumor size, location, axillary node status, recurrence rate, and cosmetic result. Results Malignant NAC involvement was found in 2 of 34 NSM (5.9%) completed for cancer which prompted subsequent removal of the NAC. Of the 51 NSM, 17 were for prophylaxis, 10 for ductal carcinoma in situ (DCIS), and 24 for invasive cancer. The average tumor size was 2.8 cm for invasive cancer and 2.5 cm for DCIS. Nine patients had positive axillary nodes. Overall, 94% of the tumors were located peripherally in the breast. After mean follow-up of 18 months, only two patients (5.9%) had local recurrence. Conclusion Using careful patient selection and careful pathological evaluation of the subareolar breast tissue at surgery, NSM can be an oncologically safe procedure in patients where this is important to their quality of life. A prospective study based on focused selection criteria and long-term follow-up is currently in progress.