Identification of salivary autoantibodies as biomarkers of oral cancer with immunoglobulin A enrichment combined with affinity mass spectrometry

• Published in: Proteomics (Weinheim) Vol. 23; no. 9; pp. e2200321 - n/a
• Main Authors: Chu, Hao‐Wei, Chang, Kai‐Ping, Yen, Wei‐Chen, Liu, Hao‐Ping, Chan, Xiu‐Ya, Liu, Chiao‐Rou, Hung, Chu‐Mi, Wu, Chih‐Ching
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2023
• Subjects: Affinity; Antigens; Autoantibodies; Autoantibodies - analysis; autoantibody; Beads; biomarker; Biomarkers; Biomarkers, Tumor - analysis; Cancer; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Humans; Immunoassay; Immunoglobulin A; Immunoglobulin A - analysis; Mass spectrometry; Mass spectroscopy; Mouth Neoplasms - diagnosis; Mouth Neoplasms - pathology; Oral cancer; Oral carcinoma; Oral cavity; oral cavity squamous cell carcinoma; proteomics; Quantitation; rab GTP-Binding Proteins - analysis; Reagents; Saliva; Saliva - chemistry; Scientific imaging; Squamous cell carcinoma; Tandem Mass Spectrometry; saliva; autoantibody; proteomics; biomarker; oral cavity squamous cell carcinoma

Globally, oral cavity squamous cell carcinoma (OSCC) is one of the most common fatal illnesses. Its high mortality is ascribed to the fact that the disease is often diagnosed at a late stage, which indicates an urgent need for approaches for the early detection of OSCC. The use of salivary autoantib...