Detection and quantification of vitamins in microliter volumes of biological samples by LC‐MS for clinical screening
A method for simultaneous determination of water‐soluble vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxamine), B9 and fat‐soluble vitamins E (α‐tocopherol) and K1 in tears, and B1, B2, B3, B5, B6, B9, A (retinol), and E in blood serum is described. Liquid chromatography‐mass spectrometry (LC‐MS...
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| Published in | AIChE journal Vol. 64; no. 10; pp. 3709 - 3718 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
01.10.2018
American Institute of Chemical Engineers |
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| Online Access | Get full text |
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| Abstract | A method for simultaneous determination of water‐soluble vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxamine), B9 and fat‐soluble vitamins E (α‐tocopherol) and K1 in tears, and B1, B2, B3, B5, B6, B9, A (retinol), and E in blood serum is described. Liquid chromatography‐mass spectrometry (LC‐MS) was used with a ternary mobile phase of water and acetonitrile containing 0.1% formic acid and methanol containing 5 mM ammonium formate. Vitamins were quantified using an internal standard method. Using 25 μL injection volumes, the limits of detection were in the range of 0.066‐5.3 ng in tear, and 0.087‐1.1 ng in serum with linear responses for all vitamins. Intra‐ and inter‐day precision and recoveries were satisfactory. This is the first study to demonstrate simultaneous vitamin detections in microliters of biological samples which has distinct advantages in many diagnostic applications with limited available fluids (e.g., tears; elderly anemic blood) or sampling small subjects (e.g., rodents). © 2018 American Institute of Chemical Engineers AIChE J, 64: 3709–3718, 2018 |
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| AbstractList | A method for simultaneous determination of water‐soluble vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxamine), B9 and fat‐soluble vitamins E (α‐tocopherol) and K1 in tears, and B1, B2, B3, B5, B6, B9, A (retinol), and E in blood serum is described. Liquid chromatography‐mass spectrometry (LC‐MS) was used with a ternary mobile phase of water and acetonitrile containing 0.1% formic acid and methanol containing 5 mM ammonium formate. Vitamins were quantified using an internal standard method. Using 25 μL injection volumes, the limits of detection were in the range of 0.066‐5.3 ng in tear, and 0.087‐1.1 ng in serum with linear responses for all vitamins. Intra‐ and inter‐day precision and recoveries were satisfactory. This is the first study to demonstrate simultaneous vitamin detections in microliters of biological samples which has distinct advantages in many diagnostic applications with limited available fluids (e.g., tears; elderly anemic blood) or sampling small subjects (e.g., rodents). © 2018 American Institute of Chemical Engineers AIChE J, 64: 3709–3718, 2018 A method for simultaneous determination of water‐soluble vitamins B 1 , B 2 , B 3 (nicotinamide), B 5 , B 6 (pyridoxamine), B 9 and fat‐soluble vitamins E (α‐tocopherol) and K 1 in tears, and B 1 , B 2 , B 3 , B 5 , B 6 , B 9 , A (retinol), and E in blood serum is described. Liquid chromatography‐mass spectrometry (LC‐MS) was used with a ternary mobile phase of water and acetonitrile containing 0.1% formic acid and methanol containing 5 mM ammonium formate. Vitamins were quantified using an internal standard method. Using 25 μL injection volumes, the limits of detection were in the range of 0.066‐5.3 ng in tear, and 0.087‐1.1 ng in serum with linear responses for all vitamins. Intra‐ and inter‐day precision and recoveries were satisfactory. This is the first study to demonstrate simultaneous vitamin detections in microliters of biological samples which has distinct advantages in many diagnostic applications with limited available fluids (e.g., tears; elderly anemic blood) or sampling small subjects (e.g., rodents). © 2018 American Institute of Chemical Engineers AIChE J , 64: 3709–3718, 2018 |
| Author | Khaksari, Maryam Mazzoleni, Lynn R. Minerick, Adrienne R. Hershey, Neil D. Ruan, Chunhai Song, Peng Kennedy, Robert T. Burns, Mark A. |
| Author_xml | – sequence: 1 givenname: Maryam orcidid: 0000-0003-0259-1775 surname: Khaksari fullname: Khaksari, Maryam organization: Michigan Technological University – sequence: 2 givenname: Lynn R. orcidid: 0000-0002-0226-7337 surname: Mazzoleni fullname: Mazzoleni, Lynn R. organization: Michigan Technological University – sequence: 3 givenname: Chunhai surname: Ruan fullname: Ruan, Chunhai organization: University of Michigan Medical School – sequence: 4 givenname: Peng surname: Song fullname: Song, Peng organization: University of Michigan – sequence: 5 givenname: Neil D. surname: Hershey fullname: Hershey, Neil D. organization: University of Michigan – sequence: 6 givenname: Robert T. surname: Kennedy fullname: Kennedy, Robert T. organization: University of Michigan – sequence: 7 givenname: Mark A. orcidid: 0000-0001-7384-4165 surname: Burns fullname: Burns, Mark A. organization: University of Michigan – sequence: 8 givenname: Adrienne R. orcidid: 0000-0002-2382-7831 surname: Minerick fullname: Minerick, Adrienne R. email: minerick@mtu.edu organization: Michigan Technological University |
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| Cites_doi | 10.4103/0301-4738.53054 10.1016/j.jchromb.2012.06.024 10.1111/j.1749-6632.1985.tb18432.x 10.1016/j.chroma.2014.08.003 10.1021/ac971329e 10.1006/abio.2000.4913 10.1016/j.chroma.2012.04.067 10.1016/j.aca.2006.03.099 10.1016/j.aca.2013.05.062 10.1001/archopht.1987.01060030096034 10.1021/ac101950r 10.1016/j.dib.2017.02.033 10.1080/10826079708000485 10.1016/0021-9673(92)85300-I 10.3109/02713683.2012.688235 10.1007/s00216-009-3373-9 10.1021/acs.analchem.6b02325 10.1007/s00216-010-3623-x 10.1093/chromsci/46.3.225 10.1021/acs.jafc.5b00087 10.1373/clinchem.2007.099077 10.1002/bmc.2683 10.1002/rcm.5073 10.1016/j.exer.2016.12.007 10.1039/c3an36394e 10.1007/BF02491661 10.1021/jf2028329 10.1016/j.pharmthera.2008.04.002 10.1373/clinchem.2004.031831 10.1039/a909027d 10.1309/J32UF7GTQPWN25AP 10.1016/j.aca.2004.02.027 10.1001/jama.1982.03320470062035 10.1002/rcm.3014 10.1016/j.chroma.2008.02.054 10.1002/jps.2600840409 10.1016/j.jasms.2005.07.017 10.1002/9780470774571 10.1002/jssc.200401858 10.3109/02713688809047018 10.1134/S1061934810030135 |
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| References | 2012; 60 2001; 289 2012; 1261 2004; 520 1987; 105 2004; 27 May 2010; 397 2010 1997; 20 2013; 789 2002; 55 1998 2012; 903 1992; 623 2008; 54 1982; 247 2004 1985; 447 2014; 1362 2012; 37 2017; 155 2010; 83 1999 2011; 9 2010; 22 2008; 1188 1995; 84 2010; 65 1989; 50 2009; 57 2004; 50 2000; 125 2017; 11 2013; 138 2015; 63 1988; 7 2008; 119 2010; 397 2008; 46 1998; 70 2011; 25 2012; 26 2005; 15 2007; 21 2005; 16 2006; 569 2006; 125 2016; 88 e_1_2_7_3_1 e_1_2_7_7_1 Fairbanks V (e_1_2_7_47_1) 1999 e_1_2_7_17_1 Lippi G (e_1_2_7_52_1) 2011; 9 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 Kaufman HE (e_1_2_7_5_1) 1998 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_37_1 Johnson LE (e_1_2_7_48_1) Küçükbay FZ (e_1_2_7_19_1) 2010; 22 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 Harris DC (e_1_2_7_39_1) 2010 Ekinci R (e_1_2_7_9_1) 2005; 15 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_27_1 e_1_2_7_29_1 McClain CJ (e_1_2_7_51_1) 1982; 247 e_1_2_7_30_1 e_1_2_7_53_1 Van Agtmaal EJ (e_1_2_7_31_1) 1989; 50 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_20_1 e_1_2_7_36_1 e_1_2_7_38_1 |
| References_xml | – volume: 520 start-page: 57 issue: 1‐2 year: 2004 end-page: 67 article-title: Simultaneous determination of water‐ and fat‐soluble vitamins in pharmaceutical preparations by high‐performance liquid chromatography coupled with diode array detection publication-title: Anal Chim Acta – volume: 37 start-page: 871 issue: 10 year: 2012 end-page: 878 article-title: Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV‐B irradiation publication-title: Curr Eye Res – volume: 289 start-page: 89 issue: 1 year: 2001 end-page: 95 article-title: Quantitative analysis by liquid chromatography–tandem mass spectrometry of deuterium‐labeled and unlabeled vitamin E in biological samples publication-title: Anal Biochem – volume: 9 start-page: 4 issue: 1 year: 2011 end-page: 9 article-title: Vitamin K in neonates: facts and myths publication-title: Blood Transfus – volume: 22 start-page: 4083 issue: 5 year: 2010 end-page: 4091 article-title: Simultaneous determination of water and fat‐soluble vitamins in Pekmez samples by high performance liquid chromatography coupled with diode array detection publication-title: Asian J Chem – volume: 138 start-page: 2146 issue: 7 year: 2013 end-page: 2155 article-title: An approach for quantitative analysis of vitamins D and B9 and their metabolites in human biofluids by on‐line orthogonal sample preparation and sequential mass spectrometry detection publication-title: Analyst – volume: 247 start-page: 3116 issue: 22 year: 1982 end-page: 3117 article-title: Biotin deficiency in an adult during home parenteral nutrition publication-title: JAMA – volume: 155 start-page: 54 year: 2017 end-page: 63 article-title: Determination of water‐soluble and fat‐soluble vitamins in tears and blood serum of infants and parents by liquid chromatography/mass spectrometry publication-title: Exp Eye Res – volume: 789 start-page: 65 year: 2013 end-page: 73 article-title: Sequential determination of fat‐ and water‐soluble vitamins in root from trans‐Himalaya with rapid resolution liquid chromatography/tandem mass spectrometry publication-title: Anal Chim Acta – volume: 1362 start-page: 270 year: 2014 end-page: 277 article-title: Simultaneous analysis for water‐ and fat‐soluble vitamins by a novel single chromatography technique unifying supercritical fluid chromatography and liquid chromatography publication-title: J Chromatogr A – volume: 119 start-page: 55 issue: 1 year: 2008 end-page: 73 article-title: Nucleotides in ocular secretions: their role in ocular physiology publication-title: Pharmacol Ther – volume: 83 start-page: 92 issue: 1 year: 2010 end-page: 98 article-title: Isotope dilution liquid chromatography‐mass spectrometry methods for fat‐ and water‐soluble vitamins in nutritional formulations publication-title: Anal Chem – volume: 55 start-page: 289 issue: 5 year: 2002 end-page: 296 article-title: Determination of vitamins A, D, E, and K in human and bovine serum, and β‐carotene and vitamin A palmitate in cosmetic and pharmaceutical products, by isocratic HPLC publication-title: Chromatographia – volume: 70 start-page: 4394 issue: 20 year: 1998 end-page: 4400 article-title: Silver‐plated vitamins: a method of detecting tocopherols and carotenoids in LC/ESI‐MS coupling publication-title: Anal Chem – volume: 25 start-page: 1942 issue: 14 year: 2011 end-page: 1948 article-title: Determination of vitamins A, D and E in a small volume of human plasma by a high‐throughput method based on liquid chromatography/tandem mass spectrometry publication-title: Rapid Commun Mass Spectrom – volume: 88 start-page: 10427 issue: 21 year: 2016 end-page: 10436 article-title: Combined measurement of 6 fat‐soluble vitamins and 26 water‐soluble functional vitamin markers and amino acids in 50 μL of serum or plasma by high‐throughput mass spectrometry publication-title: Anal Chem – volume: 903 start-page: 7 year: 2012 end-page: 13 article-title: Ultra‐performance liquid chromatography tandem mass‐spectrometry (UPLC‐MS/MS) for the rapid, simultaneous analysis of thiamin, riboflavin, flavin adenine dinucleotide, nicotinamide and pyridoxal in human milk publication-title: J Chromatogr B Analyt Technol Biomed Life Sci – volume: 16 start-page: 1805 issue: 11 year: 2005 end-page: 1811 article-title: Sensitive LC MS quantitative analysis of carbohydrates by Cs+ attachment publication-title: J Am Soc Mass Spectrom – volume: 569 start-page: 169 issue: 1–2 year: 2006 end-page: 175 article-title: High‐performance liquid chromatography/electrospray ionization‐mass spectrometry for simultaneous determination of taurine and 10 water‐soluble vitamins in multivitamin tablets publication-title: Anal Chim Acta – volume: 27 start-page: 1181 issue: 14 year: 2004 end-page: 1188 article-title: Development of a validated HPLC method for the determination of B‐complex vitamins in pharmaceuticals and biological fluids after solid phase extraction publication-title: J Sep Sci – volume: 57 start-page: 289 issue: 4 year: 2009 end-page: 292 article-title: Tear ascorbic acid levels and the total antioxidant status in contact lens wearers: a pilot study publication-title: Indian J Ophthalmol – volume: 60 start-page: 566 issue: 2 year: 2012 end-page: 573 article-title: U‐HPLC‐MS/MS to quantify liposoluble antioxidants in red‐ripe tomatoes, grown under different salt stress levels publication-title: J Agric Food Chem – volume: 21 start-page: 1745 issue: 11 year: 2007 end-page: 1754 article-title: Identification and determination of fat‐soluble vitamins and metabolites in human serum by liquid chromatography/triple quadrupole mass spectrometry with multiple reaction monitoring publication-title: Rapid Commun Mass Spectrom – year: 2010 – start-page: 1690 year: 1999 end-page: 1698 – volume: 447 start-page: 129 issue: 1 year: 1985 end-page: 132 article-title: Assessment of biotin status: clinical implications publication-title: Ann N Y Acad Sci – volume: 46 start-page: 225 issue: 3 year: 2008 end-page: 232 article-title: Simultaneous determination of four water‐soluble vitamins in fortified infant foods by ultra‐performance liquid chromatography coupled with triple quadrupole mass spectrometry publication-title: J Chromatogr Sci – volume: 63 start-page: 3135 issue: 12 year: 2015 end-page: 3143 article-title: Multicomponent analysis of fat‐ and water‐soluble vitamins and auxiliary substances in multivitamin preparations by qNMR publication-title: J Agric Food Chem – start-page: 1104 year: 1998 – volume: 125 start-page: 427 issue: 3 year: 2000 end-page: 431 article-title: Simultaneous determination of fat‐soluble vitamins and provitamins in dairy products by liquid chromatography with a narrow‐bore column publication-title: Analyst – volume: 125 start-page: 914 issue: 6 year: 2006 end-page: 920 article-title: Quantification of serum 25‐hydroxyvitamin D(2) and D(3) using HPLC‐tandem mass spectrometry and examination of reference intervals for diagnosis of vitamin D deficiency publication-title: Am J Clin Pathol – volume: 623 start-page: 69 issue: 1 year: 1992 end-page: 74 article-title: High‐performance liquid chromatography with electrochemical detection for the simultaneous determination of vitamin A, D3 and E in milk publication-title: J Chromatogr A – volume: 20 start-page: 3203 issue: 19 year: 1997 end-page: 3231 article-title: Simultaneous determination of nine water and fat soluble vitamins after SPE separation and RP‐HPLC analysis in pharmaceutical preparations and biological fluids publication-title: J Liq Chromatogr Relat Technol – volume: 50 start-page: 198 issue: 6–7 year: 1989 end-page: 199 article-title: Effect of vitamin A supplements on the retinol in tear fluid publication-title: Voeding (The Hague) – volume: 26 start-page: 1228 issue: 10 year: 2012 end-page: 1233 article-title: Determination of lipoic acid, Trolox methyl ether and tocopherols in human plasma by liquid‐chromatography and ion‐trap tandem mass spectrometry publication-title: Biomed Chromatogr – year: 2004 – volume: 7 start-page: 43 issue: 1 year: 1988 end-page: 48 article-title: The effect of vitamin‐A supplementation on tear fluid retinol levels of marginally nourished preschool‐children publication-title: Curr Eye Res – volume: 105 start-page: 376 issue: 3 year: 1987 end-page: 377 article-title: Vitamin C levels in human tears publication-title: Arch Ophthalmol – volume: 11 start-page: 316 year: 2017 end-page: 330 article-title: Data representing two separate LC‐MS methods for detection and quantification of water‐soluble and fat‐soluble vitamins in tears and blood serum publication-title: Data Brief – volume: 1188 start-page: 234 issue: 2 year: 2008 end-page: 241 article-title: Profiling of different bioactive compounds in functional drinks by high‐performance liquid chromatography publication-title: J Chromatogr A – volume: 54 start-page: 901 issue: 5 year: 2008 end-page: 906 article-title: Rapid HPLC measurement of thiamine and its phosphate esters in whole blood publication-title: Clin Chem – volume: 50 start-page: 1415 issue: 8 year: 2004 end-page: 1417 article-title: Candidate reference method for the quantification of circulating 25‐hydroxyvitamin D3 by liquid chromatography‐tandem mass spectrometry publication-title: Clin Chem – volume: 15 start-page: 289 year: 2005 end-page: 297 article-title: Determination of seven water‐soluble vitamins in Tarhana, a traditional Turkish cereal food, by high‐performance liquid chromatography publication-title: Acta Chromatogr – volume: 397 start-page: 471 issue: 2 year: May 2010 end-page: 481 article-title: Simultaneous determination of water‐soluble vitamins in SRM 1849 infant/adult nutritional formula powder by liquid chromatography‐isotope dilution mass spectrometry publication-title: Anal Bioanal Chem – volume: 65 start-page: 287 issue: 3 year: 2010 end-page: 292 article-title: Simultaneous determination of fat‐ and water‐soluble vitamins by microemulsion electrokinetic chromatography publication-title: J Anal Chem – volume: 1261 start-page: 179 year: 2012 end-page: 188 article-title: Sequential determination of fat‐ and water‐soluble vitamins in green leafy vegetables during storage publication-title: J Chromatogr A – volume: 84 start-page: 433 issue: 4 year: 1995 end-page: 436 article-title: Determination of vitamin A, vitamin E, and their esters in tablet preparations using supercritical‐fluid extraction and HPLC publication-title: J Pharm Sci – volume: 397 start-page: 1297 issue: 3 year: 2010 end-page: 1306 article-title: Chemometrics‐assisted spectrophotometric method for simultaneous determination of vitamins in complex mixtures publication-title: Anal Bioanal Chem – ident: e_1_2_7_34_1 doi: 10.4103/0301-4738.53054 – ident: e_1_2_7_42_1 doi: 10.1016/j.jchromb.2012.06.024 – volume-title: Quantitative Chemical Analysis year: 2010 ident: e_1_2_7_39_1 – ident: e_1_2_7_49_1 doi: 10.1111/j.1749-6632.1985.tb18432.x – volume: 22 start-page: 4083 issue: 5 year: 2010 ident: e_1_2_7_19_1 article-title: Simultaneous determination of water and fat‐soluble vitamins in Pekmez samples by high performance liquid chromatography coupled with diode array detection publication-title: Asian J Chem – ident: e_1_2_7_29_1 doi: 10.1016/j.chroma.2014.08.003 – ident: e_1_2_7_40_1 doi: 10.1021/ac971329e – ident: e_1_2_7_45_1 doi: 10.1006/abio.2000.4913 – volume: 50 start-page: 198 issue: 6 year: 1989 ident: e_1_2_7_31_1 article-title: Effect of vitamin A supplements on the retinol in tear fluid publication-title: Voeding (The Hague) – ident: e_1_2_7_25_1 doi: 10.1016/j.chroma.2012.04.067 – ident: e_1_2_7_10_1 doi: 10.1016/j.aca.2006.03.099 – ident: e_1_2_7_26_1 doi: 10.1016/j.aca.2013.05.062 – ident: e_1_2_7_33_1 doi: 10.1001/archopht.1987.01060030096034 – ident: e_1_2_7_2_1 doi: 10.1021/ac101950r – ident: e_1_2_7_7_1 doi: 10.1016/j.dib.2017.02.033 – ident: e_1_2_7_54_1 doi: 10.1080/10826079708000485 – ident: e_1_2_7_16_1 doi: 10.1016/0021-9673(92)85300-I – ident: e_1_2_7_32_1 doi: 10.3109/02713683.2012.688235 – volume: 9 start-page: 4 issue: 1 year: 2011 ident: e_1_2_7_52_1 article-title: Vitamin K in neonates: facts and myths publication-title: Blood Transfus – ident: e_1_2_7_38_1 – ident: e_1_2_7_12_1 doi: 10.1007/s00216-009-3373-9 – ident: e_1_2_7_35_1 – ident: e_1_2_7_46_1 – ident: e_1_2_7_20_1 doi: 10.1021/acs.analchem.6b02325 – ident: e_1_2_7_23_1 doi: 10.1007/s00216-010-3623-x – ident: e_1_2_7_8_1 doi: 10.1093/chromsci/46.3.225 – ident: e_1_2_7_22_1 doi: 10.1021/acs.jafc.5b00087 – ident: e_1_2_7_37_1 doi: 10.1373/clinchem.2007.099077 – ident: e_1_2_7_41_1 doi: 10.1002/bmc.2683 – ident: e_1_2_7_18_1 doi: 10.1002/rcm.5073 – start-page: 1104 volume-title: The Cornea year: 1998 ident: e_1_2_7_5_1 – ident: e_1_2_7_6_1 doi: 10.1016/j.exer.2016.12.007 – ident: e_1_2_7_28_1 doi: 10.1039/c3an36394e – ident: e_1_2_7_14_1 doi: 10.1007/BF02491661 – ident: e_1_2_7_44_1 doi: 10.1021/jf2028329 – ident: e_1_2_7_4_1 doi: 10.1016/j.pharmthera.2008.04.002 – ident: e_1_2_7_50_1 doi: 10.1373/clinchem.2004.031831 – ident: e_1_2_7_15_1 doi: 10.1039/a909027d – ident: e_1_2_7_53_1 doi: 10.1309/J32UF7GTQPWN25AP – ident: e_1_2_7_21_1 doi: 10.1016/j.aca.2004.02.027 – start-page: 1690 volume-title: Tietz Textbook of Clinical Chemistry year: 1999 ident: e_1_2_7_47_1 – volume: 247 start-page: 3116 issue: 22 year: 1982 ident: e_1_2_7_51_1 article-title: Biotin deficiency in an adult during home parenteral nutrition publication-title: JAMA doi: 10.1001/jama.1982.03320470062035 – ident: e_1_2_7_36_1 – ident: e_1_2_7_13_1 doi: 10.1002/rcm.3014 – ident: e_1_2_7_27_1 doi: 10.1016/j.chroma.2008.02.054 – ident: e_1_2_7_17_1 doi: 10.1002/jps.2600840409 – ident: e_1_2_7_43_1 doi: 10.1016/j.jasms.2005.07.017 – ident: e_1_2_7_3_1 doi: 10.1002/9780470774571 – ident: e_1_2_7_11_1 doi: 10.1002/jssc.200401858 – ident: e_1_2_7_30_1 doi: 10.3109/02713688809047018 – ident: e_1_2_7_24_1 doi: 10.1134/S1061934810030135 – volume-title: Vitamin Deficiency, Dependency, and Toxicity. Merck Manual for Health Care Professionals ident: e_1_2_7_48_1 – volume: 15 start-page: 289 year: 2005 ident: e_1_2_7_9_1 article-title: Determination of seven water‐soluble vitamins in Tarhana, a traditional Turkish cereal food, by high‐performance liquid chromatography publication-title: Acta Chromatogr |
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| Snippet | A method for simultaneous determination of water‐soluble vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxamine), B9 and fat‐soluble vitamins E... A method for simultaneous determination of water‐soluble vitamins B 1 , B 2 , B 3 (nicotinamide), B 5 , B 6 (pyridoxamine), B 9 and fat‐soluble vitamins E... |
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| SubjectTerms | Acetonitrile Ammonium Biological properties Biological samples Blood blood serum Diagnostic software Diagnostic systems fat‐soluble vitamins Formic acid Ions LC‐MS Liquid chromatography Mass spectrometry Mass spectroscopy Nicotinamide Older people Organic chemistry Rodents tear Tears Ternary systems Tocopherol Vitamin A Vitamin B6 Vitamins water‐soluble vitamins |
| Title | Detection and quantification of vitamins in microliter volumes of biological samples by LC‐MS for clinical screening |
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