Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells

• Published in: Annals of neurology Vol. 47; no. 6; pp. 729 - 738
• Main Authors: Villeneuve, Nathalie, Ben-Ari, Yehzekiel, Holmes, Gregory L., Gaiarsa, Jean-Luc
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.06.2000; Willey-Liss; Wiley
• Subjects: Action Potentials; Action Potentials - drug effects; Action Potentials - physiology; Administration, Inhalation; Animals; Animals, Newborn; Biological and medical sciences; Cell Membrane; Cell Membrane - physiology; Cellular Biology; Flurothyl; Flurothyl - administration & dosage; Flurothyl - pharmacology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus; Hippocampus - physiology; Hippocampus - physiopathology; Life Sciences; Male; Medical sciences; Membrane Potentials; Membrane Potentials - drug effects; Nervous system (semeiology, syndromes); Neurology; Pyramidal Cells; Pyramidal Cells - drug effects; Pyramidal Cells - physiology; Rats; Rats, Wistar; Seizures; Seizures - chemically induced; Seizures - physiopathology; Nervous system diseases; Neonatal; Pathophysiology; Rat; Epilepsy; Rodentia; Action potential; Young animal; Cerebral disorder; Flurotyl; Electrodiagnosis; Vertebrata; Mammalia; Neuron; Convulsion; Central nervous system disease; Plasma membrane; Neurological disorder; Pyramidal neuron; Hippocampus

We investigated the effects of repeated early‐life seizures induced by flurothyl inhalation on intrinsic membrane properties of hippocampal pyramidal neurons from young rats (postnatal day 15–20). Intracellular recordings of CA1 and CA3 pyramidal neurons from flurothyl‐treated and control rats revea...