Defective function of lymphokine-activated killer cells and natural killer cells in patients with hepatocellular carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 9; no. 3; p. 471
• Main Authors: Saibara, T, Onishi, S, Sakaeda, H, Yamamoto, Y
• Format: Journal Article
• Language: English
• Published: United States 01.03.1989
• Subjects: Aged; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - physiopathology; Dose-Response Relationship, Drug; Female; Hepatitis B Surface Antigens - analysis; Humans; Interferon-gamma - biosynthesis; Interleukin-2 - pharmacology; Killer Cells, Natural - physiology; Liver Cirrhosis - pathology; Liver Cirrhosis - physiopathology; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Liver Neoplasms - physiopathology; Lymphokines - pharmacology; Male; Middle Aged; Recombinant Proteins; Time Factors

Lymphokine-activated killer activity and natural killer activity in hepatocellular carcinoma patients were assessed. Maximum lymphokine-activated killer activity was induced at 3 to 5 days of incubation, and lymphokine-activated killer activity tended to increase in a manner dose dependent of recomb...