FGF2 Antiproliferative Stimulation Induces Proteomic Dynamic Changes and High Expression of FOSB and JUNB in K‐Ras‐Driven Mouse Tumor Cells

• Published in: Proteomics (Weinheim) Vol. 18; no. 17; pp. e1800203 - n/a
• Main Authors: Vitorino, Francisca Nathalia de Luna, Montoni, Fabio, Moreno, Jaqueline Neves, Souza, Bruno Ferreira, Lopes, Mariana de Camargo, Cordeiro, Barbara, Fonseca, Cecilia Sella, Gilmore, Joshua M., Sardiu, Mihaela I., Reis, Marcelo Silva, Florens, Laurence A., Washburn, Michael P., Armelin, Hugo Aguirre, da Cunha, Julia Pinheiro Chagas
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2018
• Subjects: Adenocarcinoma; Adrenal Cortex Neoplasms - drug therapy; Adrenal Cortex Neoplasms - metabolism; Adrenal Cortex Neoplasms - pathology; Adrenocortical Carcinoma - drug therapy; Adrenocortical Carcinoma - metabolism; Adrenocortical Carcinoma - pathology; Animal models; Animals; antiproliferative; Antiproliferatives; Carbohydrate metabolism; Carbohydrates; Cell cycle; Cell Proliferation; Delay; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA replication; FGF2; Fibroblast growth factor 2; Fibroblast Growth Factor 2 - pharmacology; Fibroblast growth factor receptors; Fibroblasts; FOSB; FosB protein; Gene expression; Growth factors; Humans; JUNB; JunB protein; Metabolism; Mice; Molecular modelling; Network analysis; Protein Interaction Maps; Proteins; Proteome - analysis; Proteome - metabolism; Proteomics; Proto-Oncogene Proteins c-fos - metabolism; Proto-Oncogene Proteins p21(ras) - genetics; Ras protein; Regulators; Replication; Ribonucleic acid; RNA; RNA processing; Signal Transduction; src; Stimulation; Transcription factors; Transcription Factors - metabolism; Tumor cell lines; Tumor cells; Tumor Cells, Cultured; Tumors; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; DNA replication; proteomics; src; FOSB; antiproliferative; FGF2; JUNB

Fibroblast growth factor 2 (FGF2) is a well‐known cell proliferation promoter; however, it can also induce cell cycle arrest. To gain insight into the molecular mechanisms of this antiproliferative effect, for the first time, the early systemic proteomic differences induced by this growth factor in...