Triazolization of Enolizable Ketones with Primary Amines: A General Strategy toward Multifunctional 1,2,3‐Triazoles

• Published in: Chemical record Vol. 21; no. 2; pp. 376 - 385
• Main Authors: Prakash, Rashmi, Opsomer, Tomas, Dehaen, Wim
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2021
• Subjects: 1,2,3-Triazole; Amines; Biological activity; Cyclization; Intermediates; Ketones; Substrates; Triazoles; Triazolization; Triazolization; 1,2,3-Triazole; Cyclization; Ketones; Biological activity

The development of metal‐free syntheses toward 1,2,3‐triazoles has been a burgeoning research area throughout the past decade. Despite the numerous advances, the scarceness of methods for the preparation of 1,5‐disubstituted 1,2,3‐triazoles from readily available substrates remained a challenge that...