First description of Merkel Cell polyomavirus DNA detection in a patient with Stevens-Johnson syndrome
Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood...
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| Published in | Journal of medical virology Vol. 85; no. 5; pp. 918 - 923 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.05.2013
Wiley Wiley Subscription Services, Inc |
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| Abstract | Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens–Johnson syndrome, a rare immune‐modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0 × 104 copies/ml) and in matched blood (7.4 × 105 copies/ml) from a young adult patient after bone marrow transplant for a relapsed T‐cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL‐1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens–Johnson syndrome idiopathic cases. J. Med. Virol. 85:918–923, 2013. © 2013 Wiley Periodicals, Inc. |
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| AbstractList | Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens-Johnson syndrome, a rare immune-modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0 × 10(4) copies/ml) and in matched blood (7.4 × 10(5) copies/ml) from a young adult patient after bone marrow transplant for a relapsed T-cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL-1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens-Johnson syndrome idiopathic cases. Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens-Johnson syndrome, a rare immune-modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.010 super(4) copies/ml) and in matched blood (7.410 super(5) copies/ml) from a young adult patient after bone marrow transplant for a relapsed T-cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL-1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens-Johnson syndrome idiopathic cases. J. Med. Virol. 85:918-923, 2013. [copy 2013 Wiley Periodicals, Inc. Abstract Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens–Johnson syndrome, a rare immune‐modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0 × 10 4 copies/ml) and in matched blood (7.4 × 10 5 copies/ml) from a young adult patient after bone marrow transplant for a relapsed T‐cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL‐1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens–Johnson syndrome idiopathic cases. J. Med. Virol. 85:918–923, 2013. © 2013 Wiley Periodicals, Inc. Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens-Johnson syndrome, a rare immune-modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0×104 copies/ml) and in matched blood (7.4×105 copies/ml) from a young adult patient after bone marrow transplant for a relapsed T-cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL-1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens-Johnson syndrome idiopathic cases. J. Med. Virol. 85:918-923, 2013. © 2013 Wiley Periodicals, Inc. [PUBLICATION ABSTRACT] Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens–Johnson syndrome, a rare immune‐modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0 × 104 copies/ml) and in matched blood (7.4 × 105 copies/ml) from a young adult patient after bone marrow transplant for a relapsed T‐cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL‐1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens–Johnson syndrome idiopathic cases. J. Med. Virol. 85:918–923, 2013. © 2013 Wiley Periodicals, Inc. |
| Author | Kiren, Valentina Comar, Manola Maximova, Natalia Zanon, Davide Granzotto, Marilena |
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| Cites_doi | 10.1111/j.0022-202X.2004.23536.x 10.1016/j.jcv.2010.10.015 10.1002/dc.21147 10.3201/eid1503.081206 10.3201/eid1604.091278 10.1186/gb-2008-9-6-228 10.1111/j.1365-2133.2009.09381.x 10.1111/j.1529-8019.2011.01396.x 10.1002/ijc.24509 10.1007/s00018-008-8483-6 10.1038/sj.bjc.6605306 10.1111/j.1468-3083.2010.03935.x 10.1182/blood-2010-09-310557 10.3201/eid1506.081463 10.1002/ijc.24737 10.1182/blood-2010-02-269829 10.1002/ijc.24510 10.3201/eid1509.081575 10.3201/eid1503.081067 10.1038/jid.2009.392 10.1002/ijc.23620 10.1126/science.1152586 10.1016/j.humpath.2010.01.023 10.1016/S1470-2045(04)01593-1 10.1097/MOP.0b013e32832d1fef |
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| Keywords | Bullous dermatosis Human Stevens-Johnson syndrome Skin disease Description Stomatology Polyomavirus Cidofovir Transplantation Papovaviridae Merkel cell polyomavirus bone marrow transplantation Virus Eye disease Stevens―Johnson syndrome Bone marrow Antiviral Detection |
| Language | English |
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| Notes | ark:/67375/WNG-ZVWX4LPJ-5 istex:8AB1DF5E5799A667D9CD897120ADD25C0AC4C73E N.M. and M.C. designed the study. N.M. and V.K. collected the specimens. M.C. and M.G. were in charge of the virological and cytokines analyses. V.K. and N.M. and D.Z. contributed to writing the report. M.C. and M.G. edited the final version of the text. All authors have seen and approved the manuscript. The authors declared they have no conflict of interest. Italian Ministry of Science, Italy - No. RC 11/11 ArticleID:JMV23550 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1 |
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| References | Cimbaluk D, Pitelka L, Kluskens L, Gattuso P. 2009. Update on human polyomavirus BK nephropathy. Diagn Cytopathol 37:773-779. Shuda M, Arora R, Kwun HJ, Feng H, Sarid R, Fernandez-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani MM, Swerdlow SH, Chaudhary PM, Kirkwood JM, Nalesnik MA, Kant JA, Weiss LM, Moore PS, Chang Y. 2009. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 125:1243-1249. Mertz KD, Pfaltz M, Junt T, Schmid M, Fernandez Figueras MT, Pfaltz K, Barghorn A, Kempf W. 2010b. Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin. Hum Pathol 41:1369-1379. Touze A, Gaitan J, Maruani A, Le Bidre E, Doussinaud A, Clavel C, Durlach A, Aubin F, Guyetant S, Lorette G, Coursaget P. 2009. Merkel cell polyomavirus strains in patients with merkel cell carcinoma. Emerg Infect Dis 15:960-962. Pantulu ND, Pallasch CP, Kurz AK, Kassem A, Frenzel L, Sodenkamp S, Kvasnicka HM, Wendtner CM, Zur Hausen A. 2010. Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukaemia cells. Blood 116:5280-5284. Ferrandiz-Pulido C, Garcia-Fernandez D, Dominguez-Sampedro P, Garcia-Patos V. 2011. Stevens-Johnson syndrome and toxic epidermal necrolysis in children: A review of the experience with paediatric patients in a university hospital. J Eur Acad Dermatol Venereol 25:1153-1159. Pancaldi C, Corazzari V, Maniero S, Mazzoni E, Comar M, Martini F, Tognon M. 2011. Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors. Blood 117:7099-7101. Chen T, Hedman L, Mattila PS, Jartti T, Ruuskanen O, Soderlund-Venermo M, Hedman K. 2011. Serological evidence of Merkel cell polyomavirus primary infections in childhood. J Clin Virol 50:125-129. zur Hausen H. 2008. Novel human polyomaviruses-re-emergence of a well known virus family as possible human carcinogens. Int J Cancer 123:247-250. Garneski KM, DeCaprio JA, Nghiem P. 2008. Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol 9:228. Bialasiewicz S, Lambert SB, Whiley DM, Nissen MD, Sloots TP. 2009. Merkel cell polyomavirus DNA in respiratory specimens from children and adults. Emerg Infect Dis 15:492-494. Mertz KD, Junt T, Schmid M, Pfaltz M, Kempf W. 2010a. Inflammatory monocytes are a reservoir for Merkel cell polyomavirus. J Invest Dermatol 130:1146-1151. Worswick S, Cotliar J. 2011. Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of treatment options. Dermatol Ther 24:207-218. Criado PR, Avancini J, Santi CG, Medrado AT, Rodrigues CE, de Carvalho JF. 2012. Drug reaction with eosinophilia and systemic symptoms (DRESS): A complex interaction of drugs, viruses and the immune system. Isr Med Assoc J 14:577-582. Feng H, Shuda M, Chang Y, Moore PS. 2008. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-1100. Koh MJ, Tay YK. 2009. An update on Stevens-Johnson syndrome and toxic epidermal necrolysis in children. Curr Opin Pediatr 21:505-510. Loyo M, Guerrero-Preston R, Brait M, Hoque MO, Chuang A, Kim MS, Sharma R, Liegeois NJ, Koch WM, Califano JA, Westra WH, Sidransky D. 2010. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer 126:2991-2996. Becker JC, Schrama D, Houben R. 2009. Merkel cell carcinoma. Cell Mol Life Sci 66:1-8. Foulongne V, Dereure O, Kluger N, Moles JP, Guillot B, Segondy M. 2010. Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases. Br J Dermatol 162:59-63. Goh S, Lindau C, Tiveljung-Lindell A, Allander T. 2009. Merkel cell polyomavirus in respiratory tract secretions. Emerg Infect Dis 15:489-491. Wieland U, Mauch C, Kreuter A, Krieg T, Pfister H. 2009. Merkel cell polyomavirus DNA in persons without merkel cell carcinoma. Emerg Infect Dis 15:1496-1498. Gellrich S, Schewe C, Sterry W, Lukowsky A. 2005. Absence of SV40 and other polyomavirus (JCV, BKV) DNA in primary cutaneous B cell lymphomas. J Invest Dermatol 124:278-279. Poulsen M. 2004. Merkel-cell carcinoma of the skin. Lancet Oncol 5:593-599. Koljonen V, Kukko H, Pukkala E, Sankila R, Bohling T, Tukiainen E, Sihto H, Joensuu H. 2009. Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma. Brit J Cancer 101:1444-1447. Tolstov YL, Pastrana DV, Feng H, Becker JC, Jenkins FJ, Moschos S, Chang Y, Buck CB, Moore PS. 2009. Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer 125:1250-1256. Foulongne V, Kluger N, Dereure O, Mercier G, Moles JP, Guillot B, Segondy M. 2009. Merkel cell polyomavirus in cutaneous swabs. Emerg Infect Dis 16:685-687. 2009; 66 2010a; 130 2009; 21 2011; 117 2010; 116 2005; 124 2010; 126 2011; 50 2008; 319 2008; 9 2009; 101 2004; 5 2011; 24 2010; 162 2011; 25 2010b; 41 2012; 14 2008; 123 2009; 16 2009; 125 2009; 15 2009; 37 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 Criado PR (e_1_2_7_6_1) 2012; 14 e_1_2_7_25_1 e_1_2_7_24_1 e_1_2_7_23_1 e_1_2_7_22_1 e_1_2_7_21_1 e_1_2_7_20_1 |
| References_xml | – volume: 21 start-page: 505 year: 2009 end-page: 510 article-title: An update on Stevens–Johnson syndrome and toxic epidermal necrolysis in children publication-title: Curr Opin Pediatr – volume: 50 start-page: 125 year: 2011 end-page: 129 article-title: Serological evidence of Merkel cell polyomavirus primary infections in childhood publication-title: J Clin Virol – volume: 66 start-page: 1 year: 2009 end-page: 8 article-title: Merkel cell carcinoma publication-title: Cell Mol Life Sci – volume: 319 start-page: 1096 year: 2008 end-page: 1100 article-title: Clonal integration of a polyomavirus in human Merkel cell carcinoma publication-title: Science – volume: 25 start-page: 1153 year: 2011 end-page: 1159 article-title: Stevens–Johnson syndrome and toxic epidermal necrolysis in children: A review of the experience with paediatric patients in a university hospital publication-title: J Eur Acad Dermatol Venereol – volume: 117 start-page: 7099 year: 2011 end-page: 7101 article-title: Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors publication-title: Blood – volume: 15 start-page: 489 year: 2009 end-page: 491 article-title: Merkel cell polyomavirus in respiratory tract secretions publication-title: Emerg Infect Dis – volume: 9 start-page: 228 year: 2008 article-title: Does a new polyomavirus contribute to Merkel cell carcinoma publication-title: Genome Biol – volume: 130 start-page: 1146 year: 2010a end-page: 1151 article-title: Inflammatory monocytes are a reservoir for Merkel cell polyomavirus publication-title: J Invest Dermatol – volume: 124 start-page: 278 year: 2005 end-page: 279 article-title: Absence of SV40 and other polyomavirus (JCV, BKV) DNA in primary cutaneous B cell lymphomas publication-title: J Invest Dermatol – volume: 162 start-page: 59 year: 2010 end-page: 63 article-title: Merkel cell polyomavirus DNA detection in lesional and nonlesional skin from patients with Merkel cell carcinoma or other skin diseases publication-title: Br J Dermatol – volume: 41 start-page: 1369 year: 2010b end-page: 1379 article-title: Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin publication-title: Hum Pathol – volume: 16 start-page: 685 year: 2009 end-page: 687 article-title: Merkel cell polyomavirus in cutaneous swabs publication-title: Emerg Infect Dis – volume: 15 start-page: 492 year: 2009 end-page: 494 article-title: Merkel cell polyomavirus DNA in respiratory specimens from children and adults publication-title: Emerg Infect Dis – volume: 5 start-page: 593 year: 2004 end-page: 599 article-title: Merkel‐cell carcinoma of the skin publication-title: Lancet Oncol – volume: 15 start-page: 1496 year: 2009 end-page: 1498 article-title: Merkel cell polyomavirus DNA in persons without merkel cell carcinoma publication-title: Emerg Infect Dis – volume: 125 start-page: 1250 year: 2009 end-page: 1256 article-title: Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays publication-title: Int J Cancer – volume: 24 start-page: 207 year: 2011 end-page: 218 article-title: Stevens–Johnson syndrome and toxic epidermal necrolysis: A review of treatment options publication-title: Dermatol Ther – volume: 126 start-page: 2991 year: 2010 end-page: 2996 article-title: Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission publication-title: Int J Cancer – volume: 123 start-page: 247 year: 2008 end-page: 250 article-title: Novel human polyomaviruses–re‐emergence of a well known virus family as possible human carcinogens publication-title: Int J Cancer – volume: 14 start-page: 577 year: 2012 end-page: 582 article-title: Drug reaction with eosinophilia and systemic symptoms (DRESS): A complex interaction of drugs, viruses and the immune system publication-title: Isr Med Assoc J – volume: 116 start-page: 5280 year: 2010 end-page: 5284 article-title: Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukaemia cells publication-title: Blood – volume: 125 start-page: 1243 year: 2009 end-page: 1249 article-title: Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors publication-title: Int J Cancer – volume: 37 start-page: 773 year: 2009 end-page: 779 article-title: Update on human polyomavirus BK nephropathy publication-title: Diagn Cytopathol – volume: 15 start-page: 960 year: 2009 end-page: 962 article-title: Merkel cell polyomavirus strains in patients with merkel cell carcinoma publication-title: Emerg Infect Dis – volume: 101 start-page: 1444 year: 2009 end-page: 1447 article-title: Chronic lymphocytic leukaemia patients have a high risk of Merkel‐cell polyomavirus DNA‐positive Merkel‐cell carcinoma publication-title: Brit J Cancer – ident: e_1_2_7_12_1 doi: 10.1111/j.0022-202X.2004.23536.x – ident: e_1_2_7_4_1 doi: 10.1016/j.jcv.2010.10.015 – ident: e_1_2_7_5_1 doi: 10.1002/dc.21147 – ident: e_1_2_7_13_1 doi: 10.3201/eid1503.081206 – ident: e_1_2_7_10_1 doi: 10.3201/eid1604.091278 – ident: e_1_2_7_11_1 doi: 10.1186/gb-2008-9-6-228 – ident: e_1_2_7_9_1 doi: 10.1111/j.1365-2133.2009.09381.x – ident: e_1_2_7_26_1 doi: 10.1111/j.1529-8019.2011.01396.x – ident: e_1_2_7_23_1 doi: 10.1002/ijc.24509 – ident: e_1_2_7_2_1 doi: 10.1007/s00018-008-8483-6 – ident: e_1_2_7_15_1 doi: 10.1038/sj.bjc.6605306 – ident: e_1_2_7_8_1 doi: 10.1111/j.1468-3083.2010.03935.x – ident: e_1_2_7_19_1 doi: 10.1182/blood-2010-09-310557 – volume: 14 start-page: 577 year: 2012 ident: e_1_2_7_6_1 article-title: Drug reaction with eosinophilia and systemic symptoms (DRESS): A complex interaction of drugs, viruses and the immune system publication-title: Isr Med Assoc J contributor: fullname: Criado PR – ident: e_1_2_7_24_1 doi: 10.3201/eid1506.081463 – ident: e_1_2_7_16_1 doi: 10.1002/ijc.24737 – ident: e_1_2_7_20_1 doi: 10.1182/blood-2010-02-269829 – ident: e_1_2_7_22_1 doi: 10.1002/ijc.24510 – ident: e_1_2_7_25_1 doi: 10.3201/eid1509.081575 – ident: e_1_2_7_3_1 doi: 10.3201/eid1503.081067 – ident: e_1_2_7_17_1 doi: 10.1038/jid.2009.392 – ident: e_1_2_7_27_1 doi: 10.1002/ijc.23620 – ident: e_1_2_7_7_1 doi: 10.1126/science.1152586 – ident: e_1_2_7_18_1 doi: 10.1016/j.humpath.2010.01.023 – ident: e_1_2_7_21_1 doi: 10.1016/S1470-2045(04)01593-1 – ident: e_1_2_7_14_1 doi: 10.1097/MOP.0b013e32832d1fef |
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| Snippet | Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia... Abstract Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic... |
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| SubjectTerms | Biological and medical sciences Blood Blood - virology bone marrow transplantation cidofovir Cluster Analysis Deoxyribonucleic acid DNA DNA, Viral - chemistry DNA, Viral - genetics DNA, Viral - isolation & purification Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans Infectious diseases Italy Medical sciences Merkel cell polyomavirus Merkel cell polyomavirus - genetics Merkel cell polyomavirus - isolation & purification Microbiology Miscellaneous Phylogeny Polyomavirus Sequence Analysis, DNA Skin - pathology Skin - virology Skin diseases Stevens-Johnson syndrome Stevens-Johnson Syndrome - virology Viral diseases Viral Load Virology Young Adult |
| Title | First description of Merkel Cell polyomavirus DNA detection in a patient with Stevens-Johnson syndrome |
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