Exosomes Derived From Human Urine-Derived Stem Cells Overexpressing miR-140-5p Alleviate Knee Osteoarthritis Through Downregulation of VEGFA in a Rat Model

• Published in: The American journal of sports medicine Vol. 50; no. 4; p. 1088
• Main Authors: Liu, Yuan, Zeng, Yi, Si, Hai-Bo, Tang, Li, Xie, Hui-Qi, Shen, Bin
• Format: Journal Article
• Language: English
• Published: United States 01.03.2022
• Subjects: Animals; Chondrocytes - metabolism; Down-Regulation; Exosomes - metabolism; Humans; Mesenchymal Stem Cells - metabolism; MicroRNAs - genetics; MicroRNAs - metabolism; Osteoarthritis, Knee - genetics; Osteoarthritis, Knee - metabolism; Osteoarthritis, Knee - therapy; Rats; Rats, Sprague-Dawley; Stem Cells - metabolism; Vascular Endothelial Growth Factor A - metabolism; X-Ray Microtomography; miR-140-5p; human urine–derived stem cells; intra-articular injection; vascular endothelial growth factor A; exosomes; knee osteoarthritis

Knee osteoarthritis (KOA) is one of the most common chronic musculoskeletal disorders worldwide, for which exosomes derived from stem cells may provide an effective treatment. To assess the effect of exosomes derived from human urine-derived stem cells (hUSCs) overexpressing miR-140-5p (miR means mi...