Soluble M3 proteins of murine gammaherpesviruses 68 and 72 expressed in Escherichia coli: analysis of chemokine-binding properties

• Published in: Acta virologica (Anglickâa verze) Vol. 59; no. 4; p. 360
• Main Authors: Matúšková, R, Pančík, P, Štibrániová, I, Belvončíková, P, Režuchová, I, Kúdelová, M
• Format: Journal Article
• Language: English
• Published: Slovakia 01.12.2015
• Subjects: Animals; Chemokines - immunology; Escherichia coli - genetics; Escherichia coli - metabolism; Gammaherpesvirinae - classification; Gammaherpesvirinae - genetics; Gammaherpesvirinae - immunology; Gene Expression; Herpesviridae Infections - immunology; Herpesviridae Infections - virology; Humans; Mice; Protein Structure, Tertiary; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - immunology; murine gammaherpesvirus; chemokine-binding protein; M3 protein; signal sequence

M3 protein of murine gammaherpesvirus 68 (MHV-68) was identified as a viral chemokine-binding protein 3 (vCKBP-3) capable to bind a broad spectrum of chemokines and their receptors. During both acute and latent infection MHV-68 M3 protein provides a selective advantage for the virus by inhibiting th...